Effect of Green Coffee Beans Extract Ointments for Wound Healing
DOI:
https://doi.org/10.21776/ub.jkb.2019.030.03.1Keywords:
Green coffee, histology, wound healing, wound repairAbstract
Some interventions, such as coffee powder, are applied on wound to facilitate healing process. Coffee has several properties that can facilitate wound healing. Application of Robusta coffee bean ointment 22.5 % on full thickness wound could increase fibroblast. Povidone iodine 10% has remained popular as wound antiseptic. This study aimed to evaluate the effect of green coffee bean extract in lower concentration for healing wound in rats. This study used male Sprague Dawley rats, 10 rats in each group. The skin incision was held in right back of rats with a diameter of 1.5 cm under lidocaine anesthetic subcutaneously. Group I was not given intervention, group II was given liquid povidone iodine 10%, and group III was given 15% green coffee bean extract in vaseline base. Interventions were held every day without wound debridement. Wound size was measured at day 0, 7 and 16. Animals were sacrificed at day 7 (proliferative phase) and 16 (remodeling phase). Sections were stained using Haematoxilyn-eosin. Histopathology assessment of wound tissue is on reepithelization and presence of: inflammatory cells, fibroblast, collagen, and vascularization. Green coffee extract could increase wound contraction and accelerated wound healing. Histopathology result on day 7 showed that green coffee extract had high response inflammatory cells and fibroblast. The provision of 15% green coffee bean extract ointment can accelerate wound healing with higher inflammation response and fibroblast in proliferative phase .
Downloads
References
Yuwono HS. The New Paradigm of Wound Management Using Coffee Powder. Global Journal of Surgery. 2014; 2(2): 25-29.
Kenisa YP, Istiati, dan Setyarini WJ. Effect of Robusta Coffee Beans Ointment on Full Thickness Wound Healing. Dental Journal. 2012; 45(1): 52–57.
Affonso RCL, Voytena APL, Fanan S, et al. Phytochemical Composition, Antioxidant Activity, and the Effect of the Aqueous Extract of Coffee (Coffea arabica L.) Bean Residual Press Cake on the Skin Wound Healing. Oxidative Medicine and Cellular Longevity. 2016; 2016: 1-10.
Dhivya S, Padma VV, and Santhini E. Wound Dressing-A Review. BioMedicine. 2015; 5(4): 24-28.
Bigliardi PL, Alsagoff SAL, El-Kafrawi HY, Pyon JK, Wa CTC, and Villa MA. Povidone Iodine in Wound Healing: A Review of Current Concepts and Practices. International Journal Surgery. 2017; 44: 260-268.
Gonzalez ACO, Costa TF, Andrade ZA, and Medrado ARAP. Wound Healing-A Literature Review. Anais Brasileiros de Dermatologia. 2016; 91(5): 614-620.
Sorg H, Tilkorn DJ, Hager S, Hauser J, and Mirastschijski U. Skin Wound Healing: An Update on the Current Kowledge and Concepts. European Surgical Research. 2017; 58(1-2): 81-94.
Gray C, Loynes CA, Whyte MKB, Crossman DC, Renshaw SA, and Chico TJA. Simultaneous Intravital Imaging of Macrophage and Neutrophil Behaviour during Inflammation Using a Novel Transgenic Zebrafish. Thrombosis and Haemostasis. 2011; 105(5): 811-819.
Rohl J, Zaharia A, Rudolph M, and Murray RZ. The Role of Inflammation in Cutaneous Repair. Wound Practice and Research. 2015; 23(1): 8-15.
Bainbridge P. Wound Healing and the Role of Fibroblasts. Journal of Wound Care. 2013; 22(8): 407-412.
Bagdas D, Cinkilic N, Ozboluk HY, Ozyigit MO, and Gurun MS. Antihyperalgesic Activity of Chlorogenic Acid in Experimental Neuropathic Pain. Journal of Natural Medicines. 2013; 67(4): 689-704.
Ezealisiji KM, Omotosho AE, Udoh R, and Agbo MO. Wound Healing Activity of N-Hexane and Methanol Extracts of Tetracarpidium Conophorum (Mull. Arg) Hutch (African Walnut) in Wistar Rats. Malaysian Journal of Pharmaceutical Sciences. 2014; 12(1): 79-88.
Gupta A and Kumar P. Assessment of the Histological State of the Healing Wound. Plastic and Aesthetic Research. 2015; 2(5): 239-242.
Gal P, Kilik R, Mokry M, et al. Simple Method of Open Skin Wound Healing Model in Corticosteroid-Treated and Diabetic Rats: Standardization of Semi-Quantitative and Quantitative Histological Assessments. Veterinarni Medicina. 2008; 53(12): 652-659.
Eming SA, Martin P, and Tomic-canic M. Wound Repair and Regeneration: Mechanisms, Signalin, and Translation. Science Translational Medicine. 2014; 6(265): 1-36.
Koh TJ and DiPietro LA. Inflammation and Wound Healing: The Role of the Macrophage. Expert Reviews in Molecular Medicine. 2011; 13: 1-12.
Havran WL and Jameson J. Epidermal T Cells and Wound Healing. The Journal of Immunology. 2010; 184(10): 5423-5428.
Darby IA, Laverdet B, Bonté F, and Desmoulière A. Fibroblasts and Myofibroblasts in Wound Healing. Clinical, Cosmetic, and Investigational Dermatology. 2014; 7: 301-311.
Bock O, Yu H, Zitron S, Bayat A, Ferguson MWJ, and Mrowietz U. Studies of Transforming Growth Factors Beta 1-3 and their Receptors I and II in Fibroblast of Keloids and Hypertrophic Scars. Acta Dermato- Venereologica. 2005; 85(3): 216-220.
Gilbert RWD, Vickaryous MK, and Viloria-Petit AM. Signalling by Transforming Growth Factor Beta Isoforms in Wound Healing and Tissue Regeneration. Journal of Developmental Biology. 2016; 4(21): 1-21.
Rittié L. Cellular Mechanisms of Skin Repair in Humans and Other Mammals. Journal Cell Communication and Signaling. 2016; 10(2): 103-120.
Bravo J, Arbillaga L, De Peña MP, and Cid C. Antioxidant and Genoprotective Effects of Spent Coffee Extracts in Human Cells. Food and Chemical Toxicology. 2013; 60: 397-403.
Brezová V, Šlebodová A, and Staško A. Coffee As A Source Of Antioxidants: An EPR Study. Food Chemistry. 2009; 114(3): 859–868.
Ratz-Lyko A, Arct J, Majewski S, and Pytkowska K. Influence of Polyphenols on the Physiological Processes in the Skin. Phytotherapy Research. 2015; 29(4): 509–517.
Bharath N, Sowmya NK, and Mehta DS. Determination of Antibacterial Activity of Green Coffee Bean Extract on Periodontogenic Bacteria Like Porphyromonas Gingivalis, Prevotella Intermedia, Fusobacterium Nucleatum and Aggregatibacter Actinomycetemcomitans: An In Vitro Study. Contemporary Clinical Dentistry. 2015; 6(2): 166-169.
Duangjai A, Suphrom N, Wungrath J, Ontawong A, Nuengchamnong N, and Yosboonruang A. Comparison of Antioxidant, Antimicrobial Activities and Chemical Profiles of Three Coffee (Coffea Arabica L.) Pulp Aqueous Extracts. Integrative Medicine Research. 2016; 5(4): 324-331.
Sinisi V, Stevaert A, Berti F, et al. Chlorogenic Compounds from Coffee Beans Exert Activity Against Respiratory Viruses. Planta Medica. 2017; 83(7): 615-623.
Jung S, Kim MH, Park JH, Jeong Y, and Ko KS. Cellular Antioxidant and Anti-Inflammatory Effects of Coffee Extracts with Different Roasting Levels. Journal of Medicinal Food. 2017; 20(6): 626-635.
Hwang SJ, Kim YW, Park Y, Lee HJ, and Kim KW. Anti-Inflammatory Effects of Chlorogenic Acid in Lipopolysaccharide-Stimulated RAW 264.7 Cells. Inflammation Research. 2014; 63(1): 81-90.
Chiang HM, Lin TJ, Chiu CY, et al. Coffea Arabica Extract and Its Constituents Prevent Photoaging by Suppressing MMPS Expression and MAP Kinase Pathway. Food and Chemical Toxicology. 2011; 49(1): 309-318.
Echeverri D, Montes FR, Cabrera M, Galán A, and Prieto A. Caffeine's Vascular Mechanisms of Action. International Journal of Vascular Medicine. 2010; 2010: 1-10.
Downloads
Published
Issue
Section
License
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).