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The Effect of Unripe Dates (Phoenix dactylifera) on Rat Ovarian Follicle Maturation and Ovulation

Herlambang Herlambang, Ave Olivia Rahman, Erny Kusdiyah
  Jurnal Kedokteran Brawijaya, Vol 31, No 2 (2020),  pp.77-80  

Abstract


Unripe dates are believed by Indonesian citizens to increase fertility. This study aimed to assess the effect of unripe dates in the ovary of rats. Fresh yellow-colored dates were dried in an oven and crushed into powder. Eighteen rats aged three months and had given birth once were randomly divided into three groups. The treatment groups were given unripe dates at doses of 160mg/kgBW and 320mg/kgBW through a feeding tube for 28 days, and the control group was only given distilled water. Histopathological examination was carried out by the pathology expert using Hematoxylin-Eosin staining to observe the number of ovarian follicles according to their maturation stage. The results showed that the administration of unripe dates powder 320mg/kgBW increased corpus luteum number (21.50±4.72) and was statistically significant compared to the control group (15.16±3.71). Similar differences were also found in other stages of the follicle although not statistically significant. Administration of unripe date powder can increase ovulation induction among fertile rats.

Keywords


Date palm fruit; follicle; histopathology; ovary; Phoenix dactylifera

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References


Lindsay TJ and Vitrikas KR. Evaluation and Treatment of Infertility. American Family Physician. 2015; 91(5): 308-314.

Mascarenhas MN, Flaxman SR, Boerma T, Vanderpoel S, and Stevens GA. National, Regional, and Global Trends in Infertility Prevalence since 1990: A Systematic Analysis of 277 Health Surveys. PLoS Medicine. 2012; 9(12): 1-12.

Direktorat Jenderal Pelayanan Kesehatan Kementerian Kesehatan Republik Indonesia. Infertilitas. (Online). http://www.yankes. kemkes. go.id /read--infertilitas-7828.html

Weiss RV and Clapauch R. Female Infertility of Endocrine Origin. Arquivos Brasileiros de Endocrinologia & Metabologia. 2014; 58(2): 144-152.

Rooney KL and Domar AD. The Relationship between Stress and Infertility. Dialogues in Clinical Neuroscience. 2018; 20 (1): 41-47.

Jaradat N and Zaid AN. Herbal Remedies Used for the Treatment of Infertility in Males and Females by Traditional Healers in the Rural Areas of the West Bank/Palestine. BMC Complementary and Alternative Medicine. 2019; 19: 1-12.

Bennett LR, Wiweko B, Hinting A, Adnyana IBP, and Pangestu M. Indonesian Infertility Patients’ Health Seeking Behaviour and Patterns of Access to Biomedical Infertility Care: An Interviewer Administered Survey Conducted in Three Clinics. Reproductive Health. 2012; 9(24): 1-7.

Lans C, Taylor-Swanson L and Westfall R. Herbal Fertility Treatments Used in North America from Colonial Times To 1900, and Their Potential for Improving the Success Rate of Assisted Reproductive Technology. Reproductive BioMedicine and Society Online. 2018; 5: 60–81.

Teng B, Peng J, Ong M and Qu X. Successful Pregnancy after Treatment with Chinese Herbal Medicine in a 43-Year-Old Woman with Diminished Ovarian Reserve and Multiple Uterus. Medicines. 2017; 4(7): 1-5.

Kashani L and Akhondzadeh S. Female Infertility and Herbal Medicine. Journal of Medicinal Plants. 2017; 16(61): 16-20.

Tahvilzadeh M, Hajimahmoodi M, and Rahimi R. The Role of Date Palm (Phoenix dactylifera L) Pollen in Fertility: A Comprehensive Review of Current Evidence. Journal of Evidence-Based Complementary & Alternatives Medicine. 2016; 21(4): 320-324.

Boyd KL, Muehlenbachs A, Rendi MH, Garcia RL and Gibson-Corley KN. Female Reproductive System. In: Treuting PM, Dintzis SM, and Montine KS (Eds). Comparative Anatomy and Histology a Mouse, Rat, and Human Atlas 2nd edition. Washington: Elsivier; 2018; p. 303-310.

Sato J, Nasu M, and Tsuchitani M. Comparative Histopathology of the Estrous or Menstrual Cycle in Laboratory Animals. Journal of Toxicologic Pathology. 2016; 29(3): 155–162.

Caligioni C. Assessing Reproductive Status/Stages in Mice. Current Protocol in Neuroscinece. 2009; 48(1): A.41.1-A.41.8.

Hosseini E, Mehrabani D, and Razavi F. Effect of Palm Pollen Extract on Sexual Hormone Levels and Follicle Numbers in Adult Female BALB/C mice. Quarterly of the Horizon of Medical Sciences. 2014; 20(3): 139-143.

Jihell MJ and Arrak JK. Effect of Different Doses of Ethanolic Extract of Date Palm Pollen Grains on Serum Gonadotropin and Total Glutathione in Mature Female Rats. Kufa Journal for Veterinary Medical Sciences. 2015; 6(2): 109-116.

Edelman AB, Jensen JT, Doom C, and Hennebold JD. Impact of the Prostaglandin-Synthase 2 Inhibitor Celecoxib on Ovulation and Luteal Events in Women. Contraception. 2013; 87(3): 352–357.

Williams CJ and Erickson GF. Morphology and Physiology of the Ovary. Endotext [Internet]. (Online) 2000. https://www.ncbi.nlm.nih.gov/ books/NBK278951/#top

Takagi K, Yamada T, Miki Y, Umegaki T, Nishimura M, and Sasaki J. Histological Observation of the Development of Follicles and Follicular Atresia in Immature Rat Ovaries. Acta Medica Okayama. 2007; 61(5): 283-298.




DOI: http://dx.doi.org/10.21776/ub.jkb.2020.031.02.1

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