Correlation between Atherogenic Index of Plasma and Various Domains of Cognitive Function in Type 2 Diabetes Mellitus Patients
DOI:
https://doi.org/10.21776/ub.jkb.2022.032.03.6Keywords:
Atherogenic index of plasma, cognitive, diabetes mellitusAbstract
Cognitive impairment in patients with Type 2 Diabetes Mellitus (T2DM) is related to the lack of blood supply to the brain. Previous studies showed that the atherogenic index of plasma (AIP) is a predictor of vascular abnormalities, but studies investigating its association with cognitive functions in T2DM patients younger than 60 years remain limited. This study aimed to determine the correlation between AIP and various domains of cognitive function in T2DM patients. This study was a cross-sectional study involving 75 T2DM patients selected using a consecutive sampling technique at Haji Adam Malik General Hospital Medan from July 2021 to January 2022. Cognitive function was examined using the Visual Cognitive Assessment Test Indonesian Version (VCAT-INA) on several cognition domains. The AIP value of each patient was measured and categorized into high (AIP>0.21), intermediate (AIP between >0.11 and ≤0.21), or low (≤0.11). The mean triglyceride level was 176±108.3mg/dl, the HDL-C level was 38.3±12.1mg/dl, and the mean AIP value was 0.191±0.25. The mean score of the VCAT-INA was 21.7±2.3, which was lower than normal. The AIP value showed significant negative correlation with global cognition (r=0.432, p<0.001) and various cognitive domains, namely memory (r=-0.375, p=0.001), attention (r=-0.383, p=0.001), executive function (r=-0.051, p=0.663), visuospatial (r=-0.306, p=0.008), and language (r=-0.352, p=0.002). In short, there is a significant correlation between AIP value and domains of cognitive function, such as memory, attention, visuospatial, and language domains, but not with executive domains.
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References
Verma N and Despa F. Contributing Factors to Diabetic Brain Injury and Cognitive Decline. Diabetes & Metabolism Journal. 2019; 43(5): 560-567.
Lee MK, Han K, Kim MK, et al. Changes in Metabolic Syndrome and Its Components and the Risk of Type 2 Diabetes: A Nationwide Cohort Study. Scientific Reports. 2020; 10(1): 1-8.
Jin JL, Zhang HW, Cao YX, et al. Association of Small Dense Low-Density Lipoprotein with Cardiovascular Outcome in Patients with Coronary Artery Disease and Diabetes: A Prospective, Observational Cohort Study. Cardiovascular Diabetology. 2020; 19: 1-10.
Nosrati M, Safari M, Alizadeh A, Ahmadi M, and Mahrooz A. The Atherogenic Index Log (Triglyceride/HDL-Cholesterol) as a Biomarker to Identify Type 2 Diabetes Patients with Poor Glycemic Control. International Journal of Preventive Medicine. 2021; 12: 1-5.
Guan CL, Liu HT, Chen DH, Quan XQ, Gao WL, and Duan XY. Is Elevated Triglyceride/High-Density Lipoprotein Cholesterol Ratio Associated with Poor Prognosis of Coronary Heart Disease? A Meta-Analysis of Prospective Studies. Medicine. 2022; 101(45): 1-6.
Gofir A, Mianoki A, and Nuradyo D. Correlation between Atherogenic Index of Plasma with Degree of Neurological Deficites in Acute Ischemic Stroke. Journal of the Neurological Sciences. 2017; 381(509): 374-560.
Kim SH, Cho YK, Kim YJ, et al. Association of the Atherogenic Index of Plasma with Cardiovascular Risk Beyond the Traditional Risk Factors: A Nationwide Population-Based Cohort Study. Cardiovascular Diabetology. 2022; 21(1): 1-11.
Naveen K, Singh VB, Meena BL, Kumar H, and Tiwari A. Diabetes Control, Dyslipidemia, hsCRP and Mild Cognitive Impairment in Non-Elderly People with Type 2 Diabetes Melitus. International Journal of Reaserch in Medical Sciences. 2018; 7 (2): 372-377.
Kandiah N, Zhang A, Bautista DA, et al. Early Detection of Dementia in Multilingual Populations: Visual Cognitive Assessment Test (VCAT). Neurology Neurosurgery and Psychiatry British Medical Journal. 2016; 87(2): 156-160.
Ong PA. A Novel Visual Cognitive Assessment VCAT: Visual Cognitive Assessment Test. The 5th Jakarta Neurology Exhibition, Workshop and Symposium. Jakarta. 10-11 Maret 2018
Fitri FI, Rambe AS, Ong PA, and Gultom IM. Correlation between the Indonesian Versions of Montreal Cognitive Assessment (MoCA-INA) and Visual Cognitive Assessment Test (VCAT-INA) as Cognitive Screening Tools. International Journal of Human and Health Sciences. 2022; 6(1): 47-54.
Lim L, Ng TP, Ong AP, et al. A Novel Language-Neutral Visual Cognitive Assessment Test (VCAT): Validation in Four Southeast Asian Countries. Alzheimer's Research & Therapy. 2018; 10(1): 1-9.
Perhimpunan Dokter Spesialis Saraf Indonesia. Panduan Praktik Klinik Diagnosis Penatalaksanaan Demensia. Jakarta: PERDOSSI; 2015.
Keon HC, Jang JH, Seo M, et al. The Relationship between Dyslipidemia and Alzheimer's Disease in Type 2 Diabetes Mellitus. Korean Journal of Family Practice. 2017; 7 (2): 166-171
Li K, Wei Q, Liu FF, et al. Synaptic Dysfunction in Alzheimer's Disease: Aβ, Tau, and Epigenetic Alterations. Molecular Neurobiology. 2018; 55(4): 3021-3032.
Perkumpulan Endokrinologi Indonesia. Panduan Pedoman Pengelolaan Dislipidemia di Indonesia Tahun 2019. Jakarta: PERKENI; 2019.
Attems J and Jellinger KA. The Overlap between Vascular Disease and Alzheimer's Disease-Lessons from Pathology. BMC Medicine. 2014; 12(1): 1-12.
Li R, Wang TJ, Lyu PY, et al. Effects of Plasma Lipids and Statins on Cognitive Function. Chinese Medical Journal. 2018; 131(04): 471-476.
Cho KH, Park HJ, Kim SJ, and Kim JR. Decrease in HDL-C is Associated with Age and Household Income in Adults from the Korean National Health and Nutrition Examination Survey 2017: Correlation Analysis of Low HDL-C and Poverty. International Journal of Environmental Research and Public Health. 2019; 16(18): 1-15.
Dimache AM, Șalaru DL, Sascău, R, and Stătescu C. The Role of High Triglycerides Level in Predicting Cognitive Impairment: A Review of Current Evidence. Nutrients. 2021; 13(6): 1-13.
Yasuno F and Asada T. Effect of Plasma Lipids and APOE Genotype on Cognitive Decline. Dialogues in Clinical Neuroscience. 2013; 15(1): 120-126.
Yin F. Lipid Metabolism and Alzheimer's Disease: Clinical Evidence, Mechanistic Link and Therapeutic Promise. The FEBS Journal. 2022; 1-34.
Banks WA, Farr SA, Salameh TS, et al. Triglycerides Cross the Blood–Brain Barrier and Induce Central Leptin and Insulin Receptor Resistance. International Journal of Obesity. 2018; 42(3): 391-397.
Feinkohl I, Janke J, Hadzidiakos D, et al. Associations of the Metabolic Syndrome and Its Components with Cognitive Impairment in Older Adults. BMC Geriatrics. 2019; 19(1): 1-11.
Yudia N, Syafrita Y, and Machmud R, Perbedaan Fungsi Kognitif antara Pasien Diabetes Melitus Tipe 2 dan Non Diabetes Melitus di RSUP DR M Djamil Padang. Jurnal Kesehatan Andalas. 2017; 6(2): 311-317.
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