Correlation between Chronic Kidney Disease Severity and Cognitive Function




Chronic kidney disease, cognitive function


Chronic kidney disease (CKD) is an independent risk factor for cognitive impairment in all domains, especially delayed memory and executive function. The purpose of this study was to determine the correlation between chronic kidney disease severity and cognitive function. This study used a cross-sectional design in stage III, IV, and V CKD patients in the Nephrology Polyclinic of Haji Adam Malik Central General Hospital. Cognitive function tests were performed using the Montreal Cognitive Assessment (MoCA INA), digit span, and Trail Making Test A & B. The Spearman test was used to analyze the correlation between CKD severity and cognitive function. This study involved 45 chronic kidney disease patients consisting of 28 (62.2%) males and 17 (37.8%) females with a mean age of 49.67±12.18 years. The results of statistical analysis showed that there was a significant positive correlation between CKD on the MoCA-INA examination (r=0.618, p=<0.001), FDS (r=0.414, p=0.005), there was a significant negative correlation on the TMT A time examination (r=-0.425, p=0.004), TMT A error (r=-0.497, p=0.001), TMT B time (r=-0.618, p=<0.001), TMT B error (r=-0.370, p=0.012). The results of this study prove a significant correlation between the severity of CKD and cognitive function.


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Author Biography

Epa Danisa Surbakti, Universitas sumatera utara

Neurology departement


Suwitra K. Penyakit Ginjal Kronik. In: Sudoyo AW (Ed). Buku Ajar Ilmu Penyakit Dalam. 6th edition. Jakarta: Interna Publishing; 2014; p. 2159–2165.

Richards TEF, Costa SA, Holschbach B, et al. The Montreal Cognitive Assessment (Moca)- A Sensitive Screening Instrument for Detecting Cognitive Impairment in Chronic Hemodialysis Patients. PLoS One. 2014; 9(10): 1-9.

Iyasere O and Brown EA. Cognitive Function Before and After Dialysis Initiation in Adults with Chronic Kidney Disease- a New Perspective On an Old Problem? Kidney international. 2017; 91(4): 784-786.

Tamura KM, Yaffe K, Hsu CY, et al. Cognitive Impairment and Progression of CKD. American Journal of Kidney Diseases. 2016; 68(1); 77-83.

Susianti NA, Astuti, Asmedi A, Gofir A, and Djarwoto B. Profil Fungsi Kognitif Pasien Gagal Ginjal Kronik yang Menjalani Hemodialysis. Neurona. 2015; 32(4): 1-7.

Wenstein JR and Anderson S. The Aging Kidney: Physiological Changes. Advances in Chronic Kidney Disease. 2010; 17(4): 302-307.

Aisara S, Azmi S, and Yanni M. Gambaran Klinis Penderita Penyakit Ginjal Kronik yang Menjalani Hemodialisis di RSUP Dr. M. Djamil Padang. Jurnal Kesehatan Andalas. 2018; 7(1): 42-50.

Paraizo MA, Almeida ALM, Pires LA, et al. Montreal Cognitive Assessment (Moca) Screening Mild Cognitive Impairment in Patients with Chronic Kidney Disease (CKD) Pre-Dialysis. The Brazilian Journal of Nephrology. 2016; 38(1): 31-41.

Bronas GU, Puzantian H, and Hannan M. Cognitive Impairment in Chronic Kidney Disease: Vascular Milieu and the Potential Therapeutic Role of Exercise. BioMed Research International. 2017; 2017: 1-10.

Belbessi ASE, Gohary IEE, Sheshtawi HA, and Mohamed MMA. Cognitive Disorders in Chronic Kidney Disease and Hemodialysis Patients. Journal of The Egyptian Society of Nephrology and Transplantation. 2018; 18(4): 130–136.






Research Article