User
Information for Reviewer
Index

JKB telah terindex di Crossref JKB telah terindex di Google Scholar JKB telah terindex di SINTA Ristekdikti JKB telah terindex di Portal Garuda

Notifications
Journal Content

Browse
Visitor Counter

 

Rosuvastatin Attenuated Elastic Fiber Degradation in Chronic Obstructive Pulmonary Disease Sprague-Dawley Rats

Rahmaningsih Mara Sabirin, Prasetyastuti -, Denny Agustiningsih
  Jurnal Kedokteran Brawijaya, Vol 30, No 3 (2019),  pp.175-180  

Abstract


Chronic obstructive pulmonary disease (COPD) is an incurable disease which causes disability and death. The main pathogenesis of COPD is oxidative stress due to cigarette smoke which initiates various reactions and lead to lung elastic fibers destruction. Statins are known to have antioxidant effects and reduce mortality in COPD. We studied the effects of cigarette smoke exposure cessation and rosuvastatin on oxidative stress and the level of elastic fiber destruction in COPD model rats. Thirty 10-week old male Sprague-Dawley rats were divided into 2 groups: Control (n=6, did not received fumigation nor treatment) and Smoking (n=24, received fumigation for 70 days) groups. Afterwards, the smoking group was divided into 4 groups: Sham, R2, R5,R10, and received 0.9% NaCl, 2.5, 5 and 10 mg/kg/day of rosuvastatin, respectively. Examination of malondialdehyde (MDA) and desmosine serum were conducted to measure oxidative stress and elastic fiber degradation level, respectively. After smoke exposure, MDA and desmosine levels of COPD rats were found to be significantly higher (p=0.000 and 0.000) than controls. The MDA level in Sham, R2, R5 and R10 groups decreased significantly after therapy (p=0.000; 0.033; 0.015; 0.002). However, the post-treatment desmosine level was increase significantly in Sham and R2 groups (p=0.006 dan 0.012) and insignificantly (p=0.117 dan 0.278) in the R5 and R10 groups. It can be concluded that the cessation of exposure to cigarette smoke can reduce oxidative stress, but not elastic degradation process. The administration of rosuvastatin of 5 or 10 mg/kg/day attenuated elastic degradation process.


Keywords


COPD; rosuvastatin; oxidative stress; malondialdehyde; elastic fibers degradation

Full Text:

PDF

References


WHO. WHO Global Report on Trends in Tobacco Smoking 2000-2025. Geneva, Switzerland: WHO; 2018.

Jiang B, Ma AJ, Li H, et al. Study on the Current Status of Smoking, Intention of Tobacco Concession and Related Risk Factors among 18-65-Year Olds Patients with Chronic Diseases in Beijing. Zhonghua Liu Xing Bing Xue Za Zhi. 2018; 39(4): 505-509.

Lacasse Y, Tan AYM, Maltais F, and Krishnan JA. Home Oxygen in Chronic Obstructive Pulmonary Disease. American Journal of Respiratory and Critical Care Medicine. 2018; 197(10): 1254-1264.

Sayyed AK, Despande KH, Suryakar AN, Ankush RD, and Katkam RV. Oxidative Stress and Serum α 1-Antitrypsin in Smokers. Indian Journal of Clinical Biochemistry. 2008; 23(4): 375-377.

Lindberg C, Engström G, de Verdier MG, et al. Total Desmosines in Plasma and Urine Correlate with Lung Function. The European Respiratory Journal. 2012; 39(4): 839-845.

Roisin RR, Jorgen V, Anzueto A, and Borbeau J. Global Initiative for Chronic Obstructive Lung Disease. (Online) 2011. https://goldcopd.org/wp-content/uploads/2016/12/wms-GOLD-2017-Pocket-Guide.pdf

Kristian TR, Wirjatmadi B, dan Adriani M. Pemberian Buah Kawista Menghambat Peningkatan Kadar Malondialdehid Serum Tikus Wistar yang Dipapar Asap Rokok. Jurnal Kedokteran Brawijaya. 2017; 29(3): 190-195.

Nasution AS, Wirjatmadi B, dan Adriani M. Efek Preventif Pemberian Ekstrak Kulit Buah Naga Berdaging Super Merah (Hylocereus Costaricensis) terhadap Malondialdehid Tikus Wistar yang Dipapar Asap Rokok. Jurnal Kedokteran Brawijaya. 2016; 29(1): 21-24.

Ferreira TS, Lanzetti M, Barroso MV, et al. Oxidative Stress and Inflammation are Differentially Affected By Atorvastatin, Pravastatin, Rosuvastatin, and Simvastatin on Lungs from Mice Exposed to Cigarette Smoke. Inflammation. 2014; 37(5): 1355-1365.

Yildiz T, Tasdemir MS, Tunik S, et al. Effects of Atorvastatin on Smoking-Induced Alveolar Injury in Rat Lungs. Current Therapeutic Research, Clinical and Experimental. 2009; 70(5): 366-376.

Koike K, Ishigami A, Sato Y, et al. Vitamin C Prevents Cigarette Smoke-Induced Pulmonary Emphysema in Mice and Provides Pulmonary Restoration. American Journal of Respiratory Cell and Molecular Biology. 2014; 50(2): 347-357.

Hanaoka M, Droma Y, Chen Y, et al. Carbocisteine Protects Against Emphysema Induced by Cigarette Smoke Extract in Rats. Chest. 2011; 139(5): 1101-1108.

Cao C, Wu Y, Xu Z, et al. The Effect of Statins on Chronic Obstructive Pulmonary Disease Exacerbation and Mortality: A Systematic Review and Meta-Analysis of Observational Research. Scientific Reports. 2015; 5: 1-8.

Raymakers AJN, Sadatsafavi M, Sin DD, De Vera MA, and Lynd LD. The Impact of Statin Drug Use on All-Cause Mortality in Patients with COPD: A Population-Based Cohort Study. Chest. 2017; 152(3): 486-493.

Li W-F, Huang Y-Q, Huang C, and Feng Y-Q. Statins Reduce All-Cause Mortality in Chronic Obstructive Pulmonary Disease: An Updated Systematic Review and Meta-Analysis of Observational Studies. Oncotarget. 2017; 8(42): 73000-73008.

Criner GJ, Connett JE, Aaron SD, et al. Simvastatin for the Prevention of Exacerbations in Moderate-to-Severe COPD. The New England Journal of Medicine. 2014; 370(23): 2201-2210.

Luvai A, Mbagaya W, Hall AS, and Barth JH. Rosuvastatin: A Review of the Pharmacology and Clinical Effectiveness in Cardiovascular Disease. Clinical Medicine Insights: Cardiology. 2012; 6: 17-33.

Zhang XY, Zhang C, Sun QY, et al. Infliximab Protects Against Pulmonary Emphysema in Smoking Rats. Chinese Medical Journal. 2011; 124(16): 2502-2506.

Icanervilia AV, Sunarti, and Sadewa AH. Relation between Vitamin A and Ferritin Towards Malondialdehyde Level Javanese Male Smoker. Journal of the Medical Science. 2012; 44(1): 92-98.

de Sausa Sá OM, Lopes NNF, Alves MTS, Lalla RV, Oliva MLV, and Caran EMM. Glycine Supplementation Reduces the Severity of Chemotherapy-Induced Oral Mucositis in Hamsters. Natural Science. 2013; 5(9): 972-978.

van Der Toorn M, Rezayat D, Kauffman HF, et al. Lipid-Soluble Components in Cigarette Smoke Induce Mitochondrial Production of Reactive Oxygen Species in Lung Epithelial Cells. American Journal Physiology Lung Cellular and Molecular Physiology. 2009; 297(1): 109-114.

Shah AA, Khand F, and Khand TU. Effect of Smoking on Serum Xanthine Oxidase, Malondialdehyde, Ascorbic Acid and α-Tocopherol Levels in Helathy Male Subjects. Pakistan Journal of Medical Sciences. 2014; 31(1): 146-149.

Arora KS, Guptab N, Manchanda KC, and Saluja S. Quitting Smoking Replenishes Body Antioxidant Status. International Journal of Biological & Medical Research. 2011; 2(4): 972-974.

Takata K, Imaizumi S, Kawachi E, et al. Impact of Cigarette Smoking Cessation on High-Density Lipoprotein Functionality. Circulation Journal: Official Journal of the Japanese Circulation Society. 2014; 78(12): 2955-2962.

Moon GJ, Kim SJ, Cho YH, Ryoo S, and Bang OY. Antioxidant Effects of Statins in Patients with Atherosclerotic Cerebrovascular Disease. Journal of Clinical Neurology. 2014; 10(2): 140-147.

Çetin A, Çetin İ, Yılmaz S, et al. Oxydative Stress Markers and Cytokine Levels in Rosuvastatin-Medicated Hypercholesterolemia Patients. Turkey Journal of Biochemistry. 2018; 26(7): 1-9.

Ansari JA, Bhandari U, Pillai KK, and Haque SE. Effect of Rosuvastatin on Obesity-Induced Cardiac Oxidative Stress in Wistar Rats--A Preliminary Study. Indian Journal of Experimental Biology. 2012; 50(3): 216-222.

Pires KMP, Valença SS, Resende ÂC, et al. Grape Skin Extract Reduced Pulmonary Oxidative Response in Mice Exposed to Cigarette Smoke. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research. 2011; 17(8): 187-195.

Slowik N, Ma S, He J, et al. The Effect of Secondhand Smoke Exposure on Markers of Elastin Degradation. Chest. 2011; 140(4): 946-953.

Taggart C, Cervantes-Laurean D, Kim G, et al. Oxidation of Either Methionine 351 or Methionine 358 in Α1-Antitrypsin Causes Loss of Anti-Neutrophil Elastase Activity. Journal of Biological Chemistry. 2000; 275(35): 27258-27265.

Peres FS, Barreto SM, Camelo LV, et al. Time from Smoking Cessation and Inflammatory Markers: New Evidence from a Cross-Sectional Analysis of ELSA-Brasil. Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco. 2017; 19(7): 852-858.




DOI: http://dx.doi.org/10.21776/ub.jkb.2019.030.03.2

Refbacks

  • There are currently no refbacks.