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Pengaruh Pemberian Susu Sapi Bubuk terhadap Kadar MDA Hepar pada Tikus Putih (Rattus Novergicus Strain Wistar) Jantan Model Diabetes Melitus Tipe 2

Adi Lukas Kurniawan, Fajar Ari Nugroho, Prasetyo Adi
  Jurnal Kedokteran Brawijaya, Vol 28, No 3 (2015),  pp.222-227  

Abstract


Susu sapi bubuk mengandung kalsium, dan vitamin D yang dapat mencegah peningkatan kadar Malondialdehyde (MDA) pada diabetes melltus tipe 2 melalui mekanisme perbaikan sekresi dan sensitivitas insulin. Susu sapi bubuk mampu menurunkan kondisi stress oksidatif pemicu peningkatan kadar MDA. Tujuan penelitian ini untuk mengetahui pengaruh pemberian susu sapi bubuk terhadap kadar MDA hepar pada tikus wistar model diabetes melitus tipe 2. Penelitian ini adalah penelitian eksperimental post test only control group design menggunakan 30 tikus wistar model diabetes melitus tipe 2. Selama 90 hari, kelompok perlakuan diberikan susu sapi bubuk 0,9g (P1); 1,8g (P2); dan 2,7g (P3) per hari. selanjutnya pada hari ke-91 dilakukan pengukuran kadar MDA dari jaringan hepar dengan spektrofotometer. Hasil menunjukkan terdapat pengaruh pemberian susu sapi bubuk dengan berbagai dosis terhadap kadar MDA jaringan hepar tikus (p=0,003), dengan dosis efektif adalah 1,8g/hari karena dapat mencegah peningkatan kadar MDA mendekati kelompok negatif.

Kata Kunci: Diabetes melitus tipe 2, Malondialdehyde (MDA), susu sapi bubuk


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References


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DOI: http://dx.doi.org/10.21776/ub.jkb.2015.028.03.11

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