Left Lobe Hepatocellular Carcinoma in Non-Alcoholic Fatty Liver Disease Patient: A Case Report
DOI:
https://doi.org/10.21776/ub.jkb.2024.033.02.20Keywords:
Hepatocellular carcinoma, non-alcoholic fatty liver disease, womanAbstract
Hepatocellular Carcinoma (HCC) is the second most common cause of death from cancer worldwide, affecting more men than women with a ratio of 2:1. Approximately 70–90% of HCC patients have risk factors such as chronic liver disease and liver cirrhosis. Another significant risk factor is non-alcoholic fatty liver disease (NAFLD). We report a case of left lobe hepatocellular carcinoma in a 54-year-old woman who presented with heartburn and shortness of breath, with a history of hypertension but no alcohol consumption. Chest X-ray revealed cardiomegaly without pulmonary congestion. A whole abdominal CT scan identified a left lobe hepatic tumor measuring ± 11x12x13 cm. Pathology examination revealed an epithelial mass with infiltrative, trabecular, acinar, and solid arrays, indicative of a malignant liver tumor.
Downloads
References
Menteri Kesehatan Republik Indonesia. Keputusan Menteri Kesehatan Republik Indonesia: Nomor HK.01.07/MENKES/ 1355/2022 tentang Pedoman Nasional Pelayanan Kedokteran Tata Laksana Karsinoma Sel Hati pada Dewasa. Jakarta: Kemenkes RI; 2022; p.39–97.
Martínez-Chantar ML, Avila MA, and Lu SC. Hepatocellular Carcinoma: Updates In Pathogenesis, Detection and Treatment. Cancers. 2020; 12(10): 1–4.
Cucarull B, Tutusaus A, Rider P, et al. Hepatocellular Carcinoma: Molecular Pathogenesis and Therapeutic Advances. Cancers. 2022; 14(3): 1–22.
Elmakki EE. A Rare Presentation of Hepatocellular Carcinoma in a Young Adult: A Case Report. Oman Medical Journal. 2014; 29(1): 1-3.
Wittekind C, Asamura H, and Sobin LH. Digestive System Tumours. In: Wittekind C, Asamura H, Sobin LH (Eds). TNM Atlas: Illustrated Guide to the TNM Classification of Malignant Tumours Sixth Edition. Wiley; 2017: p.72-172.
Testino G, Leone S, and Borro P. Alcohol and Hepatocellular Carcinoma: A Review and a Point of View. World Journal Gastroenterology. 2014; 20(43): 15943–15954.
Younossi Z, Stepanova M, Ong JP, et al. Nonalcoholic Steatohepatitis is the Fastest Growing Cause of Hepatocellular Carcinoma in Liver Transplant Candidates. Clinical Gastroenterology and Hepatology. 2019; 17(4): 748-755.
Pinyopornpanish K, Khoudari G, Saleh MA, et al. Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease With or Without Cirrhosis: A Population-Based Study. BMC Gastroenterology. 2021; 21(1): 1–7.
Anstee QM, Reeves HL, Kotsiliti E, Govaere O, and Heikenwalder M. From NASH to HCC: Current Concepts and Future Challenges. Nature Review. Gastroenterology & Hepatology. 2019; 16(7): 411–428.
Divella R, Mazzocca A, Daniele A, Sabbà C, and Paradiso A. Obesity, Nonalcoholic Fatty Liver Disease and Adipocytokines Network in Promotion of Cancer. International Journal of Biological Sciences. 2019; 15(3): 610–616.
Zorena K, Jachimowicz-Duda O, Ślęzak D, Robakowska M, and Mrugacz M. Adipokines and Obesity. Potential Link to Metabolic Disorders and Chronic Complications. International Journal of Moleculer Sciences. 2020; 21(10): 1-18.
Yang JD, Altekruse S, Nguyen MH, Gores GJ, Roberts LR. Impact of Country of Birth on the Age of Diagnosis of Hepatocellular Carcinoma in the United States. Cancer. 2017; 123(1): 81–89.
Macias RIR, Monte MJ, Serrano MA, et al. Impact of Aging on Primary Liver Cancer: Epidemiology, Pathogenesis and Therapeutics. Aging. 2021; 13(19): 23416–23434.
Li Q, Dhyani M, Grajo JR, Sirlin C, and Samir AE. Current Status of Imaging in Nonalcoholic Fatty Liver Disease. World Journal of Hepatology. 2018; 10(8): 530–542.
Khov N, Sharma A, and Riley TR. Bedside Ultrasound in the Diagnosis of Nonalcoholic Fatty Liver Disease. World Journal of Gastroenterology. 2014; 20(22): 6821–6825.
Livraghi T, Meloni F, Di Stasi M, et al. Sustained Complete Response and Complications Rates after Radiofrequency Ablation of Very Early Hepatocellular Carcinoma in Cirrhosis: Is Resection Still the Treatment of Choice? Hepatology. 2008; 47(1): 82–89.
Ramesh H. Resection for Hepatocellular Carcinoma. Journal of Clinical and Experimental Hepatology. 2014; 4(3): 90–96.
Jeong S, Shin WY, and Oh YH. Immunotherapy for NAFLD and NAFLD-Related Hepatocellular Carcinoma. Frontiers in Endocrinology. 2023; 14: 1-6.
Downloads
Published
Issue
Section
License
Copyright (c) 2024 Jurnal Kedokteran Brawijaya
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
