Mohs Micrographic Surgery for Morpheaform Type Basal Cell Carcinoma: A Case Report

Authors

  • Nanda Shaskia Larasaty Department of Dermatology Venereology and Aesthetics Faculty of Medicine Universitas Brawijaya Malang
  • Arif Widiatmoko Department of Dermatology Venereology and Aesthetics Faculty of Medicine Universitas Brawijaya Malang
  • Diah Prabawati Retnani Department of Anatomic Pathology Faculty of Medicine Universitas Brawijaya Malang

DOI:

https://doi.org/10.21776/ub.jkb.2025.033.03.9

Keywords:

Basal cell carcinoma, Mohs Micrographic Surgery, Morpheaform

Abstract

Morpheaform basal cell carcinoma (BCC) is an infiltrative and destructive type of BCC with a high recurrence, necessitating effective and minimally invasive management. Mohs Micrographic Surgery (MMS) is a treatment option for BCC with high conservation results of the entire tumor wall with minimal removal of surrounding healthy tissue, and the lowest recurrence rate compared to other treatment options.  In this study, we report a 48-year-old woman with dark spots on the left cheek area that had enlarged over the past year. Dermatological examinations showed hyperpigmentation patches with indistinct borders, irregular edges, and telangiectasis. Fine Needle Aspiration Biopsy (FNAB) confirmed BCC, and the patient underwent Mohs Micrographic Surgery (MMS) for tumor removal. The post-procedural follow-up showed a good outcome.

Downloads

Download data is not yet available.

References

1. Verkouteren JAC, Ramdas KHR, Wakkee M, and Nijsten T. Epidemiology of Basal Cell Carcinoma: Scholarly Review. The British Journal of Dermatology. 2017; 177(2): 359–372.

2. Cameron MC, Lee E, Hibler BP, et al. Basal Cell Carcinoma: Epidemiology; Pathophysiology; Clinical and Histological Subtypes; and Disease Associations. Journal of the American Academy of Dermatology. 2019; 80(2): 303–317.

3. Wibawa LP, Andardewi MF, Ade Krisanti I, and Arisanty R. The Epidemiology of Skin Cancer at Dr. Cipto Mangunkusumo National Central General Hospital from 2014 to 2017. Journal of General-Procedural Dermatology & Venereology Indonesia. 2019; 4(1): 11–16.

4. Arisanty R, Habiburrahman M, and Putri MAP. Clinicopathologic and Histomorphological Aspect of Basal Cell Carcinoma in Dr. Cipto Mangunkusumo Hospital: A Retrospective Analysis of Twenty Years Experience. EJournal Kedokteran Indonesia. 2021; 9(2): 118–128.

5. Naik PP and Desai MB. Basal Cell Carcinoma: A Narrative Review on Contemporary Diagnosis and Management. Oncology and Theraphy. 2022; 10(2): 317–335.

6. Conte S, Ghezelbash S, Nallanathan B, and Lefrançois P. Clinical and Molecular Features of Morpheaform Basal Cell Carcinoma: A Systematic Review. Current Oncology. 2023; 30(11): 9906–9928.

7. Bains A, Vishwajeet V, Lahoria U, and Bhardwaj A. Morpheaform Basal Cell Carcinoma Masquerading as Desmoplastic Trichoepithelioma in a Young Patient. Indian Journal of Dermatology. 2021; 66(6): 1-3.

8. Imlay RK, Torrico CP, Sulaimann A, Grimes ZM, and Monnett S. Low-Powered View, High-Powered Mind: A Case Report of Morpheaform Basal Cell Carcinoma Mistaken for Metastatic Breast Carcinoma. Cureus. 2024; 16(2): 1-7.

9. Tan ST, Ghaznawie M, Heenan PJ, Dosan R. Basal Cell Carcinoma Arises from Interfollicular Layer of Epidermis. Journal of Oncology. 2018; 2018: 1-5.

10. Zhang W, Zeng W, Jiang A, et al. Global, Regional and National Incidence, Mortality and Disability-Adjusted Life-Years of Skin Cancers and Trend Analysis from 1990 to 2019: An Analysis of the Global Burden of Disease Study 2019. Cancer Medicine. 2021; 10(14): 4905–4922.

11. Marzuka AG and Book SE. Basal Cell Carcinoma: Pathogenesis, Epidemiology, Clinical Features, Diagnosis, Histopathology, and Management. Yale Journal of Biology and Medicine. 2015; 88(2): 167–179.

12. Ungureanu L, Cosgarea I, Şenilǎ S, and Vasilovici A. Role of Dermoscopy in the Assessment of Basal Cell Carcinoma. Frontiers in Medicine. 2021; 8: 1-6.

13. Toha SS, Rahman A, Mochtar M, et al. Kejadian Karsinoma Sel Basal di RSUD Dr. Moewardi Surakarta Berdasarkan Subtipe Histopatologi Menurut Jenis Kelamin, Usia, Lokasi Anatomi, dan Diameter Tumor. Cermin Dunia Kedokteran. 2019; 46(4): 256–260.

14. Ciążyńska M, Narbutt J, Woźniacka A, Lesiak A. Trends in Basal Cell Carcinoma Incidence Rates: A 16-year Retrospective Study of a Population in Central Poland. Advances in Dermatology and Allergology. 2018; 35(1): 47–52.

15. Bassukas ID and Tatsioni A. Male Sex is an Inherent Risk Factor for Basal Cell Carcinoma. Journal of Skin Cancer. 2019; 2019: 1-5.

16. Fania L, Didona D, Morese R, et al. Basal Cell Carcinoma: From Pathophysiology to Novel Therapeutic Approaches. Biomedicines. 2020; 8(11): 1-38.

17. Mijušković ŽP. Etiology and Pathogenesis of Basal Cell Carcinoma. Serbian Journal of Dermatology and Venerology. 2013; 5(3): 113–124.

18. Niculet E, Craescu M, Rebegea L, et al. Basal Cell Carcinoma: Comprehensive Clinical and Histopathological Aspects, Novel Imaging Tools and Therapeutic Approaches (Review). Experimental and Therapeutic Medicine. 2022; 23(1): 1-8.

19. Firnhaber JM. Diagnosis and Treatment of Basal Cell and Squamous Cell Carcinoma. American Family Physician. 2012; 86(2): 161–168.

20. Nasr I, Mcgrath E, Harwood C, et al. British Association of Dermatologists Guidelines for the Management of Adults with Basal Cell Carcinoma 2021. The British Journal of Dermatology. 2021; 185(5): 899-920.

21. Daniel VT, Azzolino V, Abraham M, et al. Factors Influencing Margin Clearance and the Number of Stages of Mohs Micrographic Surgery in Basal Cell Carcinoma: A Retrospective Chart Review. Cancers (Basel). 2024; 16(13): 1-8.

22. Murray C, Sivajohanathan D, Hanna TP, et al. Patient Indications for Mohs Micrographic Surgery: A Clinical Practice Guideline. Current Oncology. 2019; 26(1): e94–99.

23. Bittner GC, Cerci FB, Kubo EM, and Tolkachjov SN. Mohs Micrographic Surgery: A Review of Indications, Technique, Outcomes, and Considerations. Anais Brasileiros de Dermatologia. 2021; 96(3): 263–277.

24. Fronek LF and Dorton D. Surgical Outcomes Following Mohs Micrographic Surgery for Basal Cell Carcinoma on the Distal Third of the Nose. Journal of Clinical and Aesthetic Dermatology. 2022; 15(6): 32–36.

25. Antonelli R and Plensdorf S. Basal Cell Carcinoma: Comparison of Surgical and Nonsurgical Interventions. American Family Physician. 2021; 104(5): 459–460.

Downloads

Published

2025-02-28

Issue

Section

Case Report

Similar Articles

1-10 of 97

You may also start an advanced similarity search for this article.

Most read articles by the same author(s)