Laporan Kasus: Hiperplasia Pseudokarsinomatus Hipofaring oleh karena Sporotrikosis
DOI:
https://doi.org/10.21776/ub.jkb.2016.029.01.18Keywords:
Hiperplasia pseudokarsinomatus, hipofaring, sporotrikosisAbstract
Hiperplasia pseudokarsinomatus merupakan proliferasi epitel reaktif jinak yang secara histopatologi mirip karsinoma sel skuamosa. Salah satu penyebabnya adalah infeksi jamur. Kami melaporkan 1 kasus hiperplasia pseudokarsinomatus hipofaring oleh karena sporotrikosis. Wanita 57 tahun mengeluh tenggorok terasa mengganjal disertai nyeri ulu hati dan sensasi pahit/kecut naik ke tenggorok. Pasien menderita refluks laringofaringeal,alergi seafood, dan riwayat Steven Johnson Syndrome. Pada pemeriksaan laringoskopi, tampak massa berdungkul pada hipofaring dengan kesan jinak. Dari hasil pemeriksaan histopatologi tampak infiltrasi epitel menuju dermis (mirip karsinoma sel skuamosa). Dengan pemeriksaan ulang secara patologi anatomi dan mikrobiologi (baku emas) serta komunikasi antara klinisi, ahli patologi, dan mikrobiologi, massa tersebut diidentifikasi sebagai hiperplasia pseudokarsinomatus oleh karena Sporothrix schenckii. Pasien menjalani eksisi massa dan diberikan ketokonazol dan lanzoprazol selama 6 minggu. Saat evaluasi ulang, pasien merasa rasa mengganjal hilang dan tidak ditemukan massa pada hipofaring. Hiperplasia pseudokarsinomatus hipofaring oleh karena sporotrikosis jarang terjadi. Di indonesia, belum ada laporan kasus mengenai hal ini. Kesalahan diagnosis sebagai karsinoma dapat berakibat fatal. Akan tetapi, dengan diagnosis yang lebih teliti dan tatalaksana yang tepat, prognosis pasien sangat baik.
Downloads
References
DAFTAR PUSTAKA
Rosen CA and Johnson JT. Bailey's Head and Neck Surgery-Otolaryngology. Baltimore: Lippincott Williams & Wllkins; 2014; p. 979.
Saraydaroglu O, Coskun H, and Elezoglu B. An Interesting Entity Mimicking Malignancy: Laryngeal Candidiasis. Journal of International Medical Research. 2010; 38(6): 2146-2152.
Mehanna HM, Kuo T, Chaplin J, Taylor G, and Morton RP. Fungal Laryngitis in Immunocompetent Patients. Journal of Laryngology and Otology. 2004; 118(5): 379-381.
Kaufmann D. Fungus Mistaken For Cancer. (Online) 2012. http://www.knowthecause.com/ index.php/doug-s-blog/316-mistakes [ diakses tanggal 12 April 2015].
Guimaraes MD, Marchiori E, and Godoy MC. Fungal Infection Mimicking Lung Cancer: A Potential Cause of Misdiagnosis. American Journal of Roentgenology. 2013; 201(2): W364.
Tami TA. Infectious and Inflammatory Disorders. In: Seiden AM, Tami TA, Pensak ML, Cotton RT, and Gluckman JL (Eds). Otolaryngology The Essentials. New York: Thieme; 2002; p. 257-258.
Anaissie EJ, McGinnis MR, and Pfaller MA. Histopathology of Fungal Infections. In: Anaissie EJ, McGinnis MR, and Pfaller MA (Eds). Clinical Mycology. 2 ed. China: Elsevier; 2009; p. 79,95.
El-Khoury J, Kibbi AG, and Abbas O. Mucocutaneous Pseudoepitheliomatous Hyperplasia: A Review. American Journal of Dermatopathology. 2012; 34(2): 165-475.
Kim ST, Kim H-J, Park IS, Park S-W, Kim WH, and Kim YM. Chronic, Reactive Conditions of the Oral Cavity Simulating Mucosal Carcinomas. Clinical Imaging. 2005; 29(6): 406-411.
Hyams VJ and Heffner DK. Laryngeal Pathology. In: Tucker HM (Ed). The Larynx 2 ed. New York: Thieme; 1993; p. 45.
Vrabec DP. Fungal Infections Of The Larynx. Otolaryngolic Clinics of North America. 1993; 26(6): 1091-1114.
Su A, Ra S, Li X, Zhou J, and Binder S. Differentiating Cutaneous Squamous Cell Carcinoma and Pseudoepitheliomatous Hyperplasia by Multiplex Qrt-PCR. Modern Pathology. 2013; 26(11): 1433-1437.
Sarin V, Bhardwaj B, Gill JS, and Singh B. Pseudoepitheliomatous Hyperplasia of Tongue Treated by Microdebrider Shaver. Pakistan Journal of Otolaryngology. 2014; 30: 26-28.
Chakrabarti S, Chakrabarti PR, Agrawal D, and Somanath S. Pseudoepitheliomatous Hyperplasia: A Clinical Entity Mistaken For Squamous Cell Carcinoma. Journal of Cutaneous and Aesthetic Surgery. 2014; 7(4): 232-234.
Rousseau A and Badoual C. Mycoses of the Head and Neck. Annales d'Oto-Laryngologie et de Chirurgie Cervico-Faciale. 2005; 122(5): 211-222.
Lopez-Romero E, Reyes-Montes Mdel R, Perez-Torres A, et al. Sporothrix Schenckii Complex And Sporotrichosis, An Emerging Health Problem. Future Microbiology. 2011; 6(1): 85-102.
Romeo O, Scordino F, and Criseo G. New Insight Into Molecular Phylogeny and Epidemiology of Sporothrix Schenckii Species Complex Based on Calmodulin-Encoding Gene Analysis of Italian Isolates. Mycopathologia. 2011; 172(3): 179-186.
Sandoval-Bernal G, Barbosa-Sabanero G, Shibayama M, Perez-Torres A, Tsutsumi V, and Sabanero M. Cell Wall Glycoproteins Participate In The Adhesion Of Sporothrix Schenckii To Epithelial Cells. Mycopathologia. 2011; 171(4): 251-259.
Anderson BE. Infectious Disease. In: Anderson BE (ED). The Netter Collection of Medical Illustrations. 2 ed. Philadelphia: Elsevier Saunders; 2012.
Romeo O and Criseo G. What Lies Beyond Genetic Diversity in Sporothrix Schenckii Species Complex? New Insights Into Virulence Profiles, Immunogenicity and Protein Secretion in S.schenckii Sensu Stricto Isolates. Virulence. 2013; 4(3): 203-206.
Zhou CH, Asuncion A, and Love GL. Laryngeal And Respiratory Tract Sporotrichosis And Steroid Inhaler Use. Archives of Pathology and Laboratory Medicine. 2003; 127(7): 893-894.
Lopes-Bezerra LM and Nascimento RC. Sporothrix schenckii and General Aspects of Sporotrichosis. In: Ruiz-Harera J (Ed). Dimorphic Fungi Their Importance as Models For Differentiation and Fungal Pathogenesis. Mexico: Bentham Science; 2012; p. 67-86.
Wink DA, Hines HB, Cheng RY, et al. Nitric Oxide and Redox Mechanisms in yhe Immune Response. Journal of Leukocyte Biology. 2011; 89(6):873-91.
Barros MBL, Paes RA, Schubach AO. Sporothrix schenckii and Sporotrichosis. Clinical Microbiology Reviews. 2011; 24(4): 633-654.
Burns MJ, Kapadia NN, Silman EF. Sporotrichosis. Western Journal of Emergency Medicine. 2009; 10(3): 204.
Alves SH, Boettcher CS, Oliveira DC, et al. Sporothrix Schenckii Associated with Armadillo Hunting in Southern Brazil: Epidemiological and Antifungal Susceptibility Profiles. Revista da Sociedade Brasileira de Medicina Tropical. 2010; 43(5): 523-525.
Calhoun DL, Waskin H, White MP, et al. Treatment of Systemic Sporotrichosis with Ketoconazole. Reviews of Infectious Disease. 1991; 13(1): 47-51.
Barkan GA and Paulino AF. Are Epidermal Growth Factor and Transforming Growth Factor Responsible for Pseudoepitheliomatous Hyperplasia Associated with Granular Cell Tumors? Annals of Diagnostic Pathology. 2003; 7(2): 73-77.
Akilov OE, Donovan MJ, Stepinac T, et al. T Helper Type 1 Cytokines and Keratinocyte Growth Factor Play a Critical Role in Pseudoepitheliomatous Hyperplasia Initiation during Cutaneous Leishmaniasis. Archives of Dermatological Research. 2007; 299(7): 315-325.
Nair AB, Chaturvedi J, Venkatasubbareddy MB, Correa M, Rajan N, and Sawkar A. A Case of Isolated Laryngeal Candidiasis Mimicking Laryngeal Carcinoma in an Immunocompetent Individual. The Malaysian Journal of Medical Sciences. 2011; 18(3): 75-78.
Guarner J and Brandt ME. Histopathologic Diagnosis of Fungal Infections in the 21st Century. Clinical Microbiology Reviews. 2011; 24(2): 247-280.
Chaya AK and Pande S. Methods of Specimen Collection for Diagnosis of Superficial and Subcutaneous Fungal Infections. Indian Journal of Dermatology, Venereology and Leprology. 2007; 73(3): 202-205.
Altman KW and Koufman JA. Laryngopharyngeal Reflux and Laryngeal Infections and Manifestations of Systemic Disease. In: Snow-Jr. JB and Wackym PA (Eds). Ballenger's Otolaryngology Head and Neck Surgery 17 edition. India: People's Medical Publishing House; 2009; p. 893.
Verma S, Verma GK, Singh G, Kanga A, et al. Sporotrichosis in Sub-Himalayan India. PLoS Neglected Tropical Disease. 2012; 6(6): e1673.
Abbas AK, Lichtman AH, Pillai S. Cellular and Molecular Immunology. 6 edition. Philadelphia: Saunders Elsevier; 2007: p. 353-360.
Soeprono FF. A Systematic Approach to Dermatopathology. California: Loma Linda; 2006; p. 164-165.
Lynch JM. Understanding Pseudoepitheliomatous Hyperplasia. Pathology Case Reviews. 2004; 9(2): 36-45.
Downloads
Published
Issue
Section
License
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).