Susu Kedelai Menurunkan Resistensi Insulin pada Model Diabetes Melitus Tipe 2


  • Wiwik Handayani Program Studi Imu Keperawatan, Sekolah Tinggi Ilmu Kesehatan Kendedes Malang
  • Ahmad Rudijanto Laboratorium Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Brawijaya
  • Mohammad Rasjad Indra Laboratorium Ilmu Faal, Fakultas Kedokteran Universitas Brawijaya



Type 2 Diabetes mellitus (T2DM) is characterized by hyperinsulinemia and hyperglicemia. Soy bean Milk ishigh nutrient drink, especially its protein contain. Several researches demonstrated that soy bean proteindecrease plasma insulin and blood glucose level. The aim of this study is to investigate the effect of soy beanmilk in reducing insulin resistance of rat T2DM Model. This experimental study used pre and post test controlgroup design. Male Rattus norvegicus wistar strain 8 week old were used as animal model. T2DM rats wereconstructed by giving high fat diet and continue with injection of low dose of streptozotocin. Rats were dividedinto 7 groups (1) Negative control group (2) Positive control group (T2DM rat without soy bean milk) (3) T2DMrat that treated with genistein 15 g/kgBW (4) T2DM rat that treated with soy bean milk 10 ml/kgBW/day (5)DMT2 rat that treated with soy bean milk 30 ml/kgBW/day (6) T2DM rat that treated with soy bean milk 60ml/kgBW/day and (7) T2DM rat that treated with soy bean milk 90 ml/kgBW/day.


Download data is not yet available.


Merentek E. Resistensi insulin pada diabetes. Tipe 2 Cermin Dunia Kedokteran. 2006; 150.

P e r k e n i . K o n s e n s u s p e n g e l o l a h a n d a n pencegahan diabetes mellitus tipe 2 di Indonesia 2006. Cetakan Pertama ed; 2006.

Saad MJA Folli F, Kahn JA, Kahn CR. Modulation of insulin receptor, insulin receptor subtrate-1, and Phosphatidylinositol 3 -kinase. J. Clinical Invest. 1993; 92: 2065-2072

Nadler ST, Stoehr JP, Rabaglia ME, et al. Normal Akt/PKB with reduced PI3K activation in insulin resistant mice. . . Am J Physiol Endocrinol Metab. 2001; 281: E1249-E1254

Tardif A, Julien N, Chiasson J-L, . et al Stimulation of glucose uptake by chronic vanadete pretreatment in cardiomyocytes requires PI-3 Kinase and p38 MAPK activation. Am J Physiol Endocrinol Metab. 2003; 284: E1055-E1064.

Kumar S and O'Rahilly S. Insulin resistance: Insulin action and its disturbances in disease. John Wiley & Sons Ltd England; 2004

Azadbakth L, Esmaillzadeh A. Soy and cardiometabolic abnormalities: an Update. Journal of Research in Medical Science. 2008; 13(2): 88-96.

Velasquez MT, Bhathena SJ. Role of dietary soy protein in obesity. International Journal of . Medical Science. 2007; 4(2): 72-82

Zhang M, Lu X-Y, Li J, . et al The characterization of high fat Diet and multiple low dose streptozotocin induced Type 2 diabetes mellitus rat model. Experimental Diabetes Research. 2008; 10.

Ali M, Muliartha IK Muwarni. , Optimalisasi diet tinggi lemak pada tikus model atherogenik. Jurnal Kedokteran Brawijaya. 2004; 3(2): 15-21.

Soeatmadji DW. The role or PPARs in the homeostasis balance of energy. Fourth Basic Molecular Biology Course In patophysiology of Obesity Brawijaya University; 2005

Ascensio C, Torres N, Isoard-Acosta F, . et al Soy protein pffect serum insulin and hepatic SREBP-1 mRNA and reduces fatty liver in rats. The journal Of Nutrition. 2004; 134: 522-529.

Wagner JD, KL Jones, L Zhang. High isoflavon soy diet increases insulin secretion without d e c r e a s i n g i n s u l i n s e n s i t i v i t y i n premenopousalnon human primates. The Journal of Nutrition. 2004; 279(34): 35298-35305






Research Article