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Penurunan Luaran Neurodevelopmental pada Sepsis Neonatal terjadi melalui Peningkatan IL- 6 dan bukan TNF-α

Rahmawati Aminingrum, Ariani Ariani, M Istiadjid ES
  Jurnal Kedokteran Brawijaya, Vol 28, No 4 (2015),  pp.314-319  

Abstract


Bayi yang mengalami gangguan pada masa prenatal, natal dan paska natal mempunyai risiko tinggi untuk mendapatkan hambatan tumbuh kembang secara optimal dibandingkan bayi lainnya. IL-6 dan TNF-α merupakan salah satu sitokin yang diproduksi saat terjadi sepsis dan mempunyai peranan pada perkembangan otak sebagai sinyal proinflamasi. Tujuan penelitian ini adalah untuk mengetahui pengaruh sepsis terhadap luaran neurodevelopmental, melalui peningkatan kadar IL-6 dan TNF α. Dua puluh neonatus yang memenuhi kriteria sepsis pada ruang perinatologi RSSA dimasukkan dalam subjek penelitian, diukur kadar IL-6 dan TNF-α saat sepsis neonatal dengan menggunakan metode ELISA, dan dinilai perkembangannya pada usia 9 bulan dengan menggunakan Bayley 3. Analisis data diolah dengan menggunakan PLS untuk menentukan pengaruh sepsis neonatal terhadap luaran neurodevelopmental. Hasil penelitian menunjukkan peningkatan IL-6 dan TNF-α pada sepsi dan penurunan luaran neurodevelopmental usia 9 bulan terutama pada aspek kognitif diikuti motorik, dan bahasa, namun tidak didapatkan pengaruh bermakna pada peningkatan TNF-α dengan luaran neurodevelopmental. Dapat disimpulkan bahwa sepsis neonatal dapat berpengaruh pada luaran neurodevelopmental usia 9 bulan melalui peningkatan IL-6 dan bukan TNF-α. Kata Kunci: IL-6, neonatal sepsis, neurodevelopmental outcome, TNF-α


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References


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DOI: http://dx.doi.org/10.21776/ub.jkb.2015.028.04.10

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