Pengaruh BDNF dan Neurotrophin Receptorpada Derajat Hidrosefalus Kongenital Pasca Ventrikulo Peritoneal Shunt

Authors

  • Farhad Bal'afif Laboratorium Bedah Saraf Fakultas Kedokteran Universitas Brawijaya Malang
  • M Aris Widodo Laboratorium Farmakologi Fakultas Kedokteran Universitas Brawijaya Malang
  • M Istiadjid ES Laboratorium Bedah Saraf Fakultas Kedokteran Universitas Brawijaya Malang
  • Abdul Hafid B Laboratorium Bedah Saraf Fakultas Kedokteran Universitas Airlangga Surabaya

DOI:

https://doi.org/10.21776/ub.jkb.2013.027.03.5

Abstract

Peningkatan  tekanan  intrakranial  (TIK)  akibat  hidrosefalus  dapat  menyebabkan  penipisan  cerebral  mantle  dan bertanggungjawab  terhadap  peningkatan  Evan's  ratio  (ER).  Apoptosis  dan  degenerasi  neuron  berperan  penting  pada perubahan patologis tersebut. Pada hidrosefalus berat terjadi ketidakpastian dari perbaikan pasca Ventrikulo-Peritoneal Shunt  (V-P  Shunt),  yang  diduga  dipengaruhi  oleh  kadar  Brain  Derived  Neurotropic  Factor  (BDNF)  dan  reseptornya. Penelitian  ini  bertujuan  untuk  membuktikan  pengaruh  Kadar  BDNF ,  solubleT yrosine  Kinase  B  (sT rkB)  dan  soluble  P75 NTRneurotrophin receptor (sP75 ) cairan serebrospinal terhadap perbaikan Evan's ratio  hidrosefalus kongenital Pasca V-P Shunt.  Cairan serebrospinal (CSS)  diambil dari 22 sampel  bayi hidrosefalus saat  dilakukan V-P Shunt,  12 jam,  24 jam  dan 3 NTRbulan  kemudian.  Kadar  BDNF ,  sT rkB  dansP75 diukur  menggunakan  tehnik  ELISA.  Derajat  hidrosefalus  di  ukur menggunakan  Evan's  ratio  dari  hasil  CT-Scan  sebelum  dan  3  bulan  pasca  V-P  Shunt.  Hasil  analisis  data  menunjukkan  bahwa delta  Evan's  ratio  3  bulan  pasca  V-P  Shunt  pada  hidrosefalus  kongenital  berkorelasi  positif  dengan  kadar  BDNF  pre  operatif dan  berkorelasi  negatif  dengan  kadar  sT rkB  pre  operatif .  Disamping  itu  delta  Evan's  ratio  3  bulan  pasca  V-P  ShuntNTRdipengaruhi  secara  negatif  oleh  delta  BDNF dan sP75   dan secara  positif  oleh  delta  sT rkB  3  bulan pasca  V-P Shunt.    Kadar NTRBDNF ,  sT rkB  dan  sP75   terlibat  pada  respon  adaptif  otak  karena  peningkatan  TIK  akibat  hidrosefalus  kongenital  dan berpengaruh  pada  perbaikan  Evan's  ratio  pasca  V-P  Shunt.

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Published

2013-04-27

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