User
Information for Reviewer
Index

JKB telah terindex di Crossref JKB telah terindex di Google Scholar JKB telah terindex di SINTA Ristekdikti JKB telah terindex di Portal Garuda

Notifications
Journal Content

Browse
Visitor Counter

 

Faktor Risiko Non Genetik dan Polimorfisme Promoter RegionGen CYP11B2Varian T(-344)C Aldosterone Synthasepada Pasien Hipertensi Esensial di Wilayah Pantai dan Pegunungan

Sundari Sundari, Aulani'am Aulani'am, Djoko Wahono S, M Aris Widodo
  Jurnal Kedokteran Brawijaya, Vol 27, No 3 (2013),  pp.169-177  

Abstract


Hipertensi  esensial  disebabkan  oleh  multifaktorial  dan  merupakan  penyakit  yang  kompleks  karena  melibatkan  faktor genetik  dan  lingkungan  atau  interaksi  antara  keduanya.  Polimorfisme  kandidat  gen   secara  genetik  menentukan  terjadinya hipertensi esensial. Salah satu polimorfisme yang berhubungan dengan hipertensi adalah gen  CYP11B2    varian  T(–344)C sebagai gen penyandi aldosterone synthase.    Penelitian ini  bertujuan untuk menganalisis interaksi    antara faktor risiko non  genetik  dengan  polimorfisme  promoter  region  gen  CYP11B2  varian  T(-344)C  pada  pasien    hipertensi  esensial    di wilayah pantai dan pegunungan, dengan desain case control study. Jumlah sampel   masing-masing kelompok kasus dan kontrol sebanyak 50 orang, sehingga keseluruhan sampel penelitian   sejumlah 100 orang.   Penentuan polimorfisme gen CYP11B2  varian  T(-344)C  menggunakan  isolasi  DNA,  polymerase  chain  reaction  (PCR)  dan  analisis  hasil  restrictrictionfragment lenght polymorphism (RFLP). Penelitian ini telah mengidentifikasi adanya polimorfisme   promoter region   gen CYP11B2  sebesar  8,3%  pada  pasien  hipertensi  esensial  di  wilayah  pantai.  Polimorfisme  berupa  adanya  mutasi  basa thymine (T) menjadi cytosine (C) pada kodon -344 pada 2 (dua) pasien hipertensi esensial di wilayah pantai. Kerentanan genetik  ditemukan  pada  individu  dengan  genotip  homozigot  TT  3  (tiga)  kali   lebih  banyak   daripada  genotip  heterozigot  TC yang  mengalami  hipertensi  esensial  baik  di  wilayah  pantai  maupun pegunungan   dan    genotip  homozigot  TT  ditemukan  8 (delapan) kali lebih banyak dari pada genotip homozigot CC di wilayah pantai. Penelitian ini memperkuat bahwa genotip TT  dan  alel  -344T  berkaitan  dengan  kecenderungan  genetik  terjadinya  hipertensi  esensial.

Full Text:

PDF

References


Horacio J, Adrogue MD, Nicolaos E, and Madias MD. Sodium and Potasium in the Pathogenesis of Hypertension. The New England Journal of Medicine 2007;356:1966-1978.

Departemen Kesehatan RI. Laporan Hasil Riset Kesehatan Dasar 2007. Jakarta: Badan Penelitian dan Pengembangan Kesehatan Departemen Kesehatan Republik Indonesia; 2007.

Lawrence JA, Michael WB, Stephen RD, Njeri K, Patricia JE, and Frank MS. Dietary Approaches to Prevent and Treat Hypertension. A Scientific Statement From the American Heart Association. Hypertension. 2006; 47: 296-274.

Catherine JC, Eleanor D, Niall HA, et al. Αlpha-Adducin and Angiotensinogen I Converting Enzym Polymorphisms Essensial Hypertension. Hypertension. 2000; 36: 990-997.

Ester B, Melanie MK, Abraham AK, Wilko S, Monique JL, and Peter WL. Alpha-Adducin Gly 460 Trp Polimorphism and Renal Hemodynamics in Essensial Hypertension. Hypertension. 2004; 44: 419-523.

Bernard C and Lauren S. Epithelial Sodium Channel: Mendelian Versus Essential Hypertension. Hypertension. 2008; 52: 595-604.

Alice HL, Lawrence JA, Michael B, et al. Summary of American Heart Association Diet and Lifestyle Recommendations Revision 2006. Arteriosclerosis, Thrombosis, and Vascular Biology. 2006; 26: 2186-2195.

Ester B, Melanie MK, Abraham AK, Wilko S, Monique JL, and Peter WL. 2004. Alpha-Adducin Gly 460 Trp Polimorphism and Renal Hemodynamics in Essensial Hypertension. Hypertension. 2004; 44: 419-523.

Esteban P, Daniel G, Vicente G, Ernesto B, Antonio C, and Alejandro. Molecular Basis of Salt Sensitivity in Human Hypertension:Evaluation of Renin-Angiotensin-Aldosterone System Gene Polymorphism. Hypertension. 2008; 38: 1204-1209.

Hlubocka, Jachymova M, Helery S, et al. Association of the-344T /C Aldosterone Synthase Gene Variant with Essential Hypertension. Physiological Research. 2009; 58:785-792.173

Ichiro K, Takashi Y, Masaki T, et al. Lys Arg and-344T/C Variants of CYP11B2 in Japanese Patients with Low Renin Hypertension. Hypertension. 2000; 35: 699-703.

Naoharu I, Kazuaki K, Hitonobu T, and Naoyuki T. Polymorphism of CYP11B2 Determines Salt Sensitivity in Japanese. Hypertension. 2007; 49: 825-831.

Carolina DC, Farhad A, Pascal B, Dierk HE, Rhian MT, and Ernesto LS. Reduced Vascular Remodelling Endothelial Dysfunction, and Oxidative Stress in Resistance Arterial of Angiotensin II-infused Macrophage Colony Stimulating Factor-Defisiency Mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 2005;25:2106-2113.

Dongfeng G, Shao Y, Dongliang G, et al. Association Study With 33 Single-Nucleotide Polymorphisms in 11 Candidate Gene for Hypertension in Chinese. Hypertension. 2006; 47:1147-1154.

Sunder-Plassmanng G, Kittler H, Berle C, et al. Angiotensin Concerting Enzyme DD Genotype is Associated with Hypertension Crisis. Critical Care Medicine. 2002; 30: 2236-2241.

Davies E, Holloway CD, Ingram MC, et al. Aldosterone Excretion Rate and Blood Pressure in Essential Hypertension are related to Polymorphic Differences in the Aldosterone Synthase Gene CYP11B2. Hypertension. 1999; 33: 703-707.

Schunkert H, Hengstenberg C, Holme SR, et al. Lack of Association Between a Polymorphism of the Aldosterone Synthase Gene and Left Ventricular Structure. Circulation. 1999; 99: 2255-2260.

Kato N, Sugiyama T, Merita H, et al. Comprehensive Analysis of the Renin-angiotensin Gene Polymorphisms with Relation to Hypertension in the Japanese. Journal of Hypertension. 2000; 18: 1025-1032.

Tsujita Y, Iwai N, Katsuya T, et al. Lack of Association between Genetic Polymorphism of CYP11B2 and Hypertension in Japanese: the Suita Study. Hypertension Reserch. 2001; 24: 105-109.

Tamaki S, Iwai N, Tsujita Y, and Kinoshita M. Genetic Polymorphism of CYP11B2 Gene and Hypertension in Japanese. Hypertension. 1999; 33: 266-270.

Kumar NN, Benjafield AV, Lin RC, Wang WY, Stowasser M, and Morfia BJ. Haplotype Analysis of Aldosterone Synthase Gene CYP11B2 Polymorphism Shows Association with Essential Hypertension. Journal of Hypertension. 2003; 21: 1331-1337

Casiglia E, Tikhonoff V, Mazza A, et al. C-344T Polymorphism of the Aldosterone Synthase Gene and Blood Pressure in the Elderly: A Population-Based Study. Journal of Hypertension. 2005; 23: 1991-1996.

Zhu H, Sagnella GA, Dong Y, et al. Contrasting Associations between Aldosterone Synthase Gene Polymorphisms and Essential Hypertension in Blacks and in Whites. Journal of Hypertension. 2003; 21: 87-95.

Sookian S, Gianotti TF, Gonzalez CD, and Pirola CJ. Association of the C-344T Aldosterone Synthase Gene Variant With Essensial Hypertension: A Meta-Analysis. Journal of Hypertension. 2007; 25: 5-13.

Clyne CD, Zhang Y, Slutsker L, Mathis JM, White PC, and Rainey WE. Angiotensin II and Potassium Regulate Human CYP11B2 Transcription Through Common Cis-Elements. Molecular Endocrinology. 1997; 11: 638-649.

Hautanen A, Lanken L, Kapuci M, et al. Associations Between Aldosterone Synthese Gene Polymorphism and Adrenocortical Function in Males., 1998; 244: 11-18.

Sookian S, Gianotti TF, Gonzalez CD, and Pirola CJ. Association of the C-344T Aldosterone Synthase Gene Variant With Essensial Hypertension: A Meta-Analysis. Journal of Hypertension. 2007; 25: 5-13.

Heller S, Linhart A, Jindra A, et al. Association of 344/T/C Aldosterone Synthase Polymorphism (CYP11B2) with Left Ventricular Structure and Humoral Parameters in Young Normotensive Men. Blood Pressure. 2004; 13: 158-163.

O´Donnell CK, Lindpainter K, Larson MG, et al. Evidence for Association and Genetic Linkage of the Angiotensin-Converting Enzyme Locus with Hypertension and Blood Pressure in Men but not Women in the Framingham Heart Study. Circulation. 1998; 97: 1766-1772. Journal of Internal Medicine




DOI: http://dx.doi.org/10.21776/ub.jkb.2013.027.03.8

Refbacks

  • There are currently no refbacks.