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Efek Pemberian Imunoterapi, Probiotik, Nigella sativa terhadap Th17, Neutrofil, dan Skoring Asma

Annisa Muhyi, Wisnu Barlianto, HMS Chandra Kusuma
  Jurnal Kedokteran Brawijaya, Vol 28, No 4 (2015),  pp.334-339  

Abstract


Peran Th17 dalam patogenesis asma dan imunoterapi menjadi konsep dan paradigma terbaru. Imunoterapi merupakan salah satu manajemen di dalam asma dan memerlukan waktu yang lama sehingga sering mengakibatkan kegagalan terapi. Terapi adjuvant antara lain probiotik dan Nigella sativa diduga dapat meningkatkan efektifitas imunoterapi. Penelitian dilakukan untuk mengevaluasi efek pemberian imunoterapi, probiotik dan/atau Nigella sativa terhadap jumlah sel Th17, neutrofil dan skoring asma pada anak asma selama imunoterapi fase rumatan. Penelitian dilakukan pada  31 anak yang dikelompokkan secara acak yaitu imunoterapi plus plasebo atau imunoterapi plus Nigella sativa atau imunoterapi plus probiotik atau imunoterapi plus Nigella sativa plus probiotik selama 56 minggu. Pengukuran jumlah sel Th17 dan neutrofil dilakukan menggunakan flowsitometri setelah perlakuan. Asthma Control Test dilakukan untuk mengevaluasi gejala klinis. Data dianalisis menggunakan uji komparasi Anova One Way dan  uji korelasi Pearson. Hasil menunjukkan tidak didapatkan perbedaan yang bermakna jumlah sel Th17 dan neutrophil antara kelompok perlakuan (p-value 0,199 dan 0,326). Asthma control test secara bermakna didapatkan perbedaan antara perlakuan imunoterapi plus probiotik dibandingkan imunoterapi saja. Skoring asma pada kelompok perlakuan imunoterapi plus probiotik adalah yang tertinggi (22,6). Jumlah sel Th17, neutrofil dan ACT menunjukkan hubungan yang lemah dan tidak bermakna secara statistik (r=-0,2) (p= 0,156). Jumlah sel Th17 dan neutrofil tidak didapatkan perbedaan yang bermakna. Skoring asma pada kelompok imunoterapi plus probiotik adalah yang tertinggi. Dapat disimpulkan tidak terdapat hubungan antara Th17, neutrofil dan skoring asma.Kata Kunci: Imunoterapi, neutrofil, Nigella sativa, probiotik, sel Th17, skoring asma


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References


Sundaru H. House Dust Mite Allergen Level and Allergen Sensitization as Risk Factors for Asthma among Student in Central Jakarta. Medical Journal of Indonesia. 2006;15(1): 55-59.

Park SJ and Lee YC. Interleukin-17 Regulation: An Attractive Therapeutic Approach for Asthma. Respiratory Research. 2010; 11(1): 11.

Fujita H, Soyka MB, Akdis M, and Akdis CA. Mechanisms of Allergen-Specific Immunotherapy. Clinical and Translational Allergy. 2012; 2: 1-8.

Bodera P and Chcialowski A. Immunomodulatory Effect of Probiotic Bacteria. Recent Patents on Inflammation & Allergy Drug Discovery. 2009; 3(1): 58-64.

Paarakh PM. Nigella sativa Linn.-A Comprehensive Review. Indian Journal of Natural Products and Resources. 2010; 1(4): 409-429.

Bateman ED, Hurd SS, Barnes PJ, et al. Global Strategy for Asthma Management and Prevention: GINA Executive Summary. Europe Respiratory Journal. 2008; 31(1): 143-178.

Divatia JV and Bhowmick K. Complications of Endotracheal Intubation and Other Airway Management Procedure. Indian Journal of Anaesthesia. 2005;49(4): 308-318.

Gupta A, Bush A, Hawrylowi C, and Saglani S. Vitamin D and Asthma In Children. Paediatric Respiratory Review 2012; 13(14): 236-243.

Supriyatno B, Wahyudin B. Patogenesis dan Patofisiologi Asma Anak. Di dalam: Rahayu NN, Supriyatno B, Setyanto DB (Eds). Buku Ajar Respirologi Anak. Jakarta: Badan Penerbit IDAI; 2010: hal. 85-98.

GINA. Global Strategy For Asthma Management And Prevention; 2014.

Cox L, Nelson H, Lockey R, et al. Allergen Immunotherapy: A Practice Parameter Third Update. Journal of Allergy and Clinical Immunology. 2010; 127(1): S 1-S55.

Cappella A and Durham SR. Allergen Immunotherapy for Allergic Respiratory Diseases. Human Vaccines & Immunotherapeutics. 2012; 8(10): 1499-1512.

Akdis M and Akdis CA. Mechanisms of Allergen-Specific Immunotherapy: Multiple Suppressor Factors at Work in Immune Tolerance to Allergens. The Journal of Allergy Clinical Immunology. 2014; 133(3): 621-631.

Ahmad A, Husain A, Mujeeb M, et al. A Review on Therapeutic Potential of Nigella sativa: A Miracle Herb. Asian Pacific Journal of Tropical Biomedicine. 2013; 3(5): 337-352.

Toh ZQ, Anzela A, Tang ML, and Licciardi PV. Probiotic Therapy as A Novel Approach for Allergic Disease. Frontiers in Pharmacology. 2012; 3: 171-183.

Kim JM, Lin SY, Suarez-Cuervo C, et al. Allergen-Specific Immunotherapy for Pediatric Asthma and Rhinoconjunctivitis: A Systematic Review. Pediatrics. 2013; 131(6): 1155-1167.

Castellazzi AM, Valsecchi C, Caimmi S, et al. Probiotic and Food Allergy. Italian Journal of Pediatrics. 2013; 39: 1-10.

Tanabe S. The Effect of Probiotics and Gut Microbiota on Th17 Cells. International Review of Immunology. 2013; 32(5-6): 511-525.

Heialy SA, Mcgovern TK, and Martin JG. Insights Into Asthmatic Airway Remodelling Through Murine Models. Respirology. 2011; 16(4): 589-597.

Baraldo S, Turato G, Bazzan E, et al. Noneosinophilic Asthma in Children: Relation with Airway Remodelling. Europe Respiratory Journal. 2011; 38(3): 575-583.

Ozdemir O. Various Effects of Different Probiotic Strains in Allergic Disorders: An Update From Laboratory and Clinical Data. Clinical and Experimental Immunology. 2010; 160(3): 295-304.

Chen YS, Jan RL, Lin YL, Chen HH, and Wang JY. Randomized Placebo-Controlled Trial of Lactobacillus on Asthmatic Children with Allergic Rhinitis. Pediatrics Pulmonoloy. 2010; 45(11): 1111-1120.

Kusuma M , Barlianto W, Widodo A, and Suharto S. Crude Extract of Black Seed (Nigella sativa) can Modulate TCD4+ and CD8+ Lymphocytes in Asthmatic Mouse Model. Paediatric Respiratory Reviews. 2012; 13(11): S55.

Abdel-Aziz M, Abass A, Zalata K, Abd Al-Galel T, Allam U, and Karrouf G. Effect of Dexamethasone and Nigella sativa on Inducible Nitric Oxide Synthase in the Lungs of a Murine Model of Allergic Asthma. Iranian Journal of Allergy, Asthma, and Immunology. 2014; 13(15): 324-334.

Bajoriūnienė I, Malakauskas K, Lavinskienė S, et al. Peripheral Blood Th17 Cells and Neutrophils in Dermatophagoides Pteronyssinus-Induced Early-and Late-Phase Asthmatic Response. Medicine (Kaunas). 2012; 48(9): 442-451.




DOI: http://dx.doi.org/10.21776/ub.jkb.2015.028.04.14

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