Anti-Methicillin-Resistant Staphylococcus aureus (MRSA) of Ethanol Extract of God's Crown (Phaleria macrocarpa) Leaves, Peel, and Fruit Flesh
DOI:
https://doi.org/10.21776/ub.jkb.2020.031.02.2Keywords:
Ethanol extract, Methicillin-resistant Staphylococcus aureus (MRSA), Phaleria macrocarpaAbstract
Methicillin-resistant Staphylococcus aureus (MRSA) is a pathogen that becomes the main concern since it is a multidrug-resistant organism and causes high morbidity and mortality. This study aimed to investigate the antibacterial activity of ethanolic extract of Phaleria macrocarpa leaves, peel, and fruit flesh on MRSA. This study was an experimental laboratory study with a post-test only control group design to assess the antibacterial activity of ethanolic extract from leaves, peel, and fruit flesh of Phaleria macrocarpa against MRSA ATCC 43300 and MRSA clinical isolates using a disk diffusion method. Extracts from the leaves, peel, and flesh of Phaleria macrocarpa had potential as an antibacterial agent against MRSA ATCC 43300 at a concentration of 40%, although not yet equivalent to antibiotic control. The ethanol extract of Phaleria macrocarpa peel at a concentration of 30-40% had potential as an antibacterial agent against MRSA clinical isolates, although not yet equivalent to antibiotic control. Further research needs to be performed so that Phaleria macrocarpa extract can be a potential source of subsequent antibacterial development against MRSA.Downloads
References
Petruta A, Horhogea C, Dimitri G, Aprotosoaie AC, and Anca M. Morusin And Kuwanon G -Promising Anti-MRSA Agents. Med. Surg. J.-Rev. Med. Chir. Soc. Med. Nat. 2019; 123(1): 195-202.
Hua X, Yang Q, Zhang W, et al. Antibacterial Activity And Mechanism Of Action Of Aspidinol Against Multi-Drug-Resistant Methicillin-Resistant Staphylococcus aureus. Frontiers in Pharmacology. 2018; 9: 1–12. https://doi.org/10.3389/fphar.2018.00619.
Li L, Yeaman, MR, Bayer AS, and Xiong YQ. Phenotypic And Genotypic Characteristics Of Methicillin-Resistant Staphylococcus Aureus (Mrsa) Related To Persistent Endovascular Infection. Antibiotics. 2019; 8(2): 11–14. https://doi.org/10.3390/antibiotics8020071
Labruère R, Sona AJ, and Turos E. Anti–Methicillin-Resistant Staphylococcus aureus Nanoantibiotics. Frontiers in Pharmacology.2019; 10: 1–24. https://doi.org/10.3389/fphar.2019.01121
WHO. Global Antimicrobial Resistance Surveillance System (GLASS) Report. 2017. In Who. https://doi.org/ISBN 978-92-4-151344-9.
Ahmed Asrity SM, Tsan FY, Ding P, and Syed Aris S. R. Functional Properties Of Phaleria macrocarpa Fruit Flesh At Different Ripeness. International Food Research Journal. 2018; 25(3): 1273–1280.
Novaryatiin S, Chusna N, and Amelia D. Uji Daya Hambat Ekstrak Etanol Daun Mahkota Dewa (Phaleria macrocarpa Boerl.,) terhadap Bakteri Staphylococcus aureus. Jurnal Surya Medika. 2018; 4(1): 28–35. https://doi.org/10.33084/jsm.v4i1.153
Alara OR, Alara JA, and Olalere OA. Review on Phaleria macrocarpa Pharmacological and Phytochemical Properties. Drug Des, an open access journal. 2016: 2169-0138.
Susilawati, Matsjeh S, Pranowo HD, and Anwar C. Two isophalerin compounds from ethyl acetate of leave and fruit of Mahkota Dewa (Phaleria macrocarpa (scheff.) Boerl.) and its antibacterial activity. Indonesian Journal of Chemistry. 2015; 15(2): 179–186. https://doi.org/10.22146/ijc.21212
Abouzeed YM , Elfahem A, Zgheel F, and Ahmed MO. Antibacterial In-Vitro Activities of Selected Medicinal Plants against Methicillin Resistant Staphylococcus Aureus from Libyan Environment. J Environ Anal Toxicol. 2013; 3: 194. doi: 10.4172/2161-0525.1000194
Astriyani W, Surjowardojo P, and Susilorini T. Daya Hambat Ekstrak Buah Mahkota Dewa (Phaleria Macrocarpa L.) Dengan Pelarut Ethanol Dan Aquades Terhadap Bakteri Staphylococcus aureus Penyebab Mastitis Pada Sapi Perah. TERNAK TROPIKA Journal of Tropical Animal Production. 2017; 18(2): 8–13. https://doi.org/10.21776/ub.jtapro.2017.018.02.2
Faried A, Bolly H, Septiani L, Kurnia D, Arifin M, and Wirakusumah F. Potential of Indonesian Herbal Medicine, Phaleria macrocarpa (Scheff.) Boerl, for Targeting Multiple Malignancy Signaling Pathways: An Introductory Overview. European Journal of Medicinal Plants. 2016; 11(2): 1–17. https://doi.org/10.9734/ejmp/2016/20760.
Afnizar M, N Mahdi dan Zuraidah. Uji Aktivitas Antibakteri Ekstrak Daun Mahkota Dewa Phaleria macrocarpa terhadap bakteri Staphylococcus aureus. Prosiding Seminar Nasional Biotik. 2016. : p.293-300.
Paulus P, Sugihartana D, and Larnani S. Efek Penghambatan Ekstrak Akuades Daun Ocimum basilicum terhadap S treptococcus mutans. Jurnal Kedokteran Brawijaya. 2018; 30(2): 87–91.
Downloads
Published
Issue
Section
License
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
