Aphrodisiac Activity of Beligo (Benincasa hispida (Thunb.) Cogn.) Seeds of Ethanol Extract in Mice

Authors

  • Nur Alim Department of Pharmacy Faculy of Mathematic and Natural Science Universitas Islam Makassar Makassar
  • Jasmiadi Jasmiadi Department of Pharmacy Faculy of Mathematic and Natural Science Universitas Islam Makassar Makassar
  • Nadia Nadillah Department of Pharmacy Faculy of Mathematic and Natural Science Universitas Islam Makassar Makassar
  • Ira Indrawaty Kadir Department of Pharmacy Faculy of Mathematic and Natural Science Universitas Islam Makassar Makassar
  • Nur Afirah Department of Pharmacy Faculy of Mathematic and Natural Science Universitas Islam Makassar Makassar

Keywords:

Aphrodisiac, beligo seed

Abstract

Beligo (Benincasa hispida (Thunb.) Cogn.), is empirically used by the people of South Sulawesi-Indonesia as an aphrodisiac. Beligo seeds contain alkaloids, phenolics, flavonoids, and unsaturated fatty acids, which have the potential to act as aphrodisiacs. The primary objective of this research is to determine the aphrodisiac activity of an ethanol extract from beligo seeds in mice.  The procedure entails extraction and aphrodisiac evaluation using introduction, climbing, and coitus test parameters. Aphrodisiac testing was carried out for seven days using 25 mice as experimental animals, divided into five groups. Each group consists of four males and one female. Group I was given Sod. CMC 1% as a negative control; II, III, and IV were given ethanol extracts of beligo seeds at doses of 350mg/kg, 700mg/kg, 1400mg/kg BW, and group V, as a positive control, was given Yohimbine. The results showed that the ethanol extract of beligo seeds at doses of 350mg/kg BW, 700mg/kg BW, and 1400mg/kg BW had aphrodisiac activity (p=0.0001) compared to Sod. CMC 1% based on data on the amount of introduction and climbing. However, based on data on the number of coitus, it showed that the ethanol extract of beligo seeds at doses of 350mg/kg BW (p=0.072) had no aphrodisiac activity, 700mg/kg BW (p=0.007), 1400mg/kg BW (p=0.0001) had aphrodisiac activity compared to Na-CMC 1% and only a dose of 1400 mg/kg BW had the same aphrodisiac activity compared with Yohimbine (p=0.967). It is concluded that the ethanol extract of beligo seeds had aphrodisiac activity.

Downloads

Download data is not yet available.

References

Mazzilli F. Erectile Dysfunction: Causes, Diagnosis and Treatment: An Update. Journal of Clinical Medicine. 2022; 11(21): 1-6.

Kotta S, Ansari SH, and Ali J. Exploring Scientifically Proven Herbal Aphrodisiacs. Pharmacognosy Review. 2013; 7(13): 1–10.

Enema OJ, Umoh UF, Umoh RA, Ekpo EG, Adesina SK, and Eseyin OA. Chemistry and Pharmacology of Aphrodisiac Plants: A Review. Journal of Chemical and Pharmaceutical Research. 2018; 10(7): 70–98.

Ganapathy AA, Priya VMH, and Kumaran A. Medicinal Plants as a Potential Source of Phosphodiesterase-5 Inhibitors: A Review. Journal of Ethnopharmacology. 2020; 267: 1-36.

Pahari N, Mahanti B, Banerjee M, Mandal K, Bhowmick B, and Roy A. A Concise Review on Benincasa Hispida (Thunb.). International Journal of Health Sciences. 2022; 6(S6): 844–853.

Al-Snafi AE. The Pharmacological Importance of Benincasa Hispida. A Review. International Journal of Pharma Sciences and Research. 2013; 4(12): 165–170.

Islam MT, Quispe C, El-Kersh DM, et al. Review Article a Literature-Based Update on Benincasa hispida (Thunb.) Cogn .: Traditional Uses, Nutraceutical, and Phytopharmacological Profiles. Oxidative Medicine and Cellular Longevity. 2021; 2021: 1-19.

Sew CC, Zaini NAM, Anwar F, HAmid AA, and Saari N. Nutritional Composition and Oil Fatty Acids of Kundur [Benincasa hispida (Thunb.) Cogn.] Seed. Pakistan Journal of Botany. 2010; 42(5): 3247–3255.

Avinash TS and Rai VR. An Ethanobotanical Investigation of Cucurbitaceae from South India: A Review. Journal of Medicinal Plants Studies. 2017; 5(3): 250–254.

Tasmin N, Erwin, and Kusuma IW. Isolasi, Identifikasi dan Uji Toksisitas Senyawa Flavonoid Fraksi Kloroform dari Daun Terap (Artocarpus Odoratissimus Blanco). Jurnal Kimia Mulawarman. 2014; 12(1): 45–53.

AK C, AV C, and MS C. Aphrodisiac and Phytochemical Studies of Citrullus Colocynthis L. Seed Extracts in Albino Rats. Austin Journal of Reproductive Medicine and Infertelity. 2017; 4(1): 1–6.

Rasyid H, Bukhari A, Alim N, Djide N, and Hasanuddin R. Antioxidant Potential and Total Phenolic of Ethanol Extract Beligo (Benincasa hispida (Thunb.) Cogn.) Seeds. Azerbaijan Medical Journal. 2022; 62(9): 4895–4907.

Alim N, Jasmiadi, Sulastri D, and Pratama AS. Aktivitas Antipiretik Ekstrak Etanol Daun Beligo (Benincasa hispida (Thunb.) Cogn.) pada Tikus. Jurnal Novem Medika Farmasi. 2022; 1(2): 40–49.

Yuda DA, Rahman AO, Kasmadi FS, and Humaryanto H. Joints Osteoarthritis Efek Anti-Inflamasi Fraksi Etil Asetat Biji Pinang terhadap Tikus Wistar Model Osteoarthritis. Jurnal Kedokteran Brawijaya. 2023; 32(3): 143–147.

Alim N, Rasyid H, Bukhari A, Djide N, Sartini, and Hasanuddin R. The Potency of Beligo Seeds (Benincasa hispida (Thunb.) Cogn.) as Antihyperlipidemic in L-NAME- Induced Hyperlipidemic Rats. Fabad Journal of Pharmaceutical Sciences. 2023; 48(2): 231–240.

Amar A, Suryawati A, and Nurani D. The Effect of Carboxy-Methyl-Cellulose (CMC) Concentration on Suspension Stability of Red Guava Syrup (Psidium Guajava L) During Storage. IOP Conference Series: Earth and Environmental Science. 2020; 472(1): 1–8.

Jabir NR, Firoz CK, Zughaibi TA, et al. A Literature Perspective on the Pharmacological Applications of Yohimbine. Annals of Medicine. 2022; 54(1): 2861–2875.

Tam SW, Worcel M, and Wyllie M. Yohimbine: A Clinical Review. Pharmacology and Therapeutics. 2001; 91(3): 215–243.

Tarkowská D. A Fast and Reliable UHPLC – MS/MS-Based Method for Screening Selected Pharmacologically Significant Natural Plant Indole Alkaloids. Molecules. 2020; 25(14): 1–15.

Mukherjee E, Gantait S, Kundu S, Sarkar S, and Bhattacharyya S. Biotechnological Interventions on the Genus Rauvolfia: Recent Trends and Imminent Prospects. Applied Microbiology and Biotechnology. 2019; 103(18): 7325–7354.

Martin LJ and Touaibia M. Improvement of Testicular Steroidogenesis Using Flavonoids and Isoflavonoids for Prevention of Late-Onset Male Hypogonadism. Antioxidants (Basel). 2020; 9(3): 1-17.

Wardani IGAAK and Santoso P. Efektivitas Afrodisiaka dari Ekstrak Etanol Jahe Merah (Zingiber officinale ROSCOE) pada Tikus (Rattus Norvegicus L.) Putih Jantan. Jurnal Ilmiah Medicamento. 2017; 3(1): 22–28.

Downloads

Published

2024-08-30

Issue

Vol. 33 No. 2 (2024)

Section

Research Article

License

Copyright (c) 2024 Jurnal Kedokteran Brawijaya

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).