User
Information for Reviewer
Index

JKB telah terindex di Crossref JKB telah terindex di Google Scholar JKB telah terindex di SINTA Ristekdikti JKB telah terindex di Portal Garuda

Notifications
Journal Content

Browse
Visitor Counter

 

Tulsi (Ocimum sanctum) Leaf Ethanol Extract Reduces Inflammatory Cell Infiltration in Aspirin-Induced Gastritis Rats

Festi Artika Sari, Willy Sandhika, Tri Hartini Yuliawati
  Jurnal Kedokteran Brawijaya, Vol 31, No 1 (2020),  pp.49-52  

Abstract


Gastritis is an inflammation of the gastric mucosa. Tulsi leaf extract has phenol, flavonoid and saponin compounds which are potential as antioxidant and increase defensive factors in the gastric. The purpose of this research was to find out the effect of tulsi (Ocimum sanctum) leaf extract in polymorphonuclear (PMN) inflammatory cell infiltration in gastric of aspirin-induced gastritis rat model. This study was laboratory experimental research using post-test only control group design. Randomly, 27 male rats were divided into 3 groups, the first group was not induced by aspirin and extract as negative control, the second group was induced by aspirin of 600 mg/kgBW as positive control, and the third group was induced by aspirin of 600 mg/kgBW and was given Ocimum sanctum extract at a dose of 400 mg/kgBW as treatment group. Gastric of the rats were taken on 16th day for histopathology evaluation using hematoxylin and eosin (HE) staining. Evaluation was done by calculating the PMN inflammatory cell infiltration in mucosal and submucosal layer. The results of the average number of PMN inflammatory cell in the gastric tissue of the treatment group showed a significant decrease compared to the positive and negative control groups with P-value <0.05. This study proved that Ocimum sanctum leaf extract administration with the dose of 400 mg/kgBW can decrease gastritis inflammation by reducing PMN inflammatory cell in gastric of aspirin-induced gastritis rat model.


Keywords


Aspirin; gastritis; inflammatory cells; Ocimum sanctum

Full Text:

PDF

References


Rugge M, Pennelli G, Pilozzi E, et al. Gastritis : The Histology Report. An International Journal of Gastroenterology and Hepatology: Digestive and Liver Disease. 2011; 43(4): S373-S384.

Selviana BY. Effect Of Coffee And Stress With The Incidence Of Gastritis. Medical Journal of Lampung University. 2015; 4(2): 1-5.

Sipponen P and Maaroos HI. Chronic gastritis. Scandinavian Journal of Gastroenterology. 2015; 50(6): 657-667.

Bi WP, Man HB, and Man MQ. Efficacy and safety of herbal medicines in treating gastric ulcer: a review. World Journal Gastroenterol. 2014; 20(45): 17020–17028.

Pattanayak P, Behera P, Das D and Panda S. Ocimum sanctum Linn. A reservoir plant for therapeutic applications: An overview. Pharmacognosy Reviews. 2010; 4(7): 95-105.

Siva M, Shanmugam KR, Shanmugam B, Venkata SG, Ravi S, Sathyavelu R K, and Mallikarjuna K. Ocimum sanctum: a review on the pharmacological properties. International Journal of Basic and Clinical Pharmacology. 2016; 5(3): 558-565.

Oktavia S, Arifin H, and Irawati R. Pengaruh Ekstrak Etanol Daun Kemangi (Ocimum sanctum L.) Terhadap PH Dan Tukak Lambung Pada Tikus Putih Jantan. Jurnal Farmasi Higea. 2015;7(2):2.

Susilawati NM, Yuliet Y, and Khaerati K. Aktivitas Gastroprotektif Ekstrak Etanol Daun Gedi Hijau (Abelmoschus Manihot (L.) Medik) Terhadap Tikus Putih Jantan (Rattus Norvegicus L.) Yang Diinduksi Dengan Aspirin. Natural Science: Journal of Science and Technology. 2018;5(3):296–306.

Turner JR and Lingen MW. Rongga Mulut dan Saluran Cerna. Di dalam: Kumar, V., Abbas, A.K. dan Aster JC. Robbins Basic Pathology edisi 9. Philadelphia, PA: Elsevier Saunder ; 2013 p. 564-569.

Kayacetin S, and Guresci S. What Is Gastritis? What Is Gastropathy? How Is It Classified?. Turkish Journal of Gastroenterology. 2014;25(3):233–247.

Lintong PM, Loho LL, and Anggran H. Gambaran Histopatologik Lambung Tikus Wistar Setelah Diinduksi dengan Aspirin. Jurnal Biomedik. 2013; 5 (1): 38-45.

Matsui H, Shimokawa O, Kaneko T, Nagano Y, Rai K, and Hyodo I. The Pathophysiology Of Non-Steroidal Anti-Inflammatory Drug (NSAID)-Induced Mucosal Injuries In Stomach And Small Intestine. J Clin Biochem Nutr. 2011;48(2):107–111.

Mirje MM, Zaman SU, and Ramabhimaiah S. Original Research Article Evaluation Of The Anti-Inflammatory Activity Of Ocimum sanctum Linn ( Tulsi ) In Albino Rats. International Journal of Current Microbiology and Applied Science. 2014;3(1):198–205.

Venkateswararao C and Venkataramana K. A Pharmacological Review on Natural Antiulcer Agents. Journal of Global Trends in Pharmaceutical Sciences. 2013; 4(3): 1118-1131.

Melinda M and Ahmad H. Efikasi Kombinasi Rebamipide dengan Lansoprazole pada Proses Penyembuhan Tukak Lambung Tikus yang Dipapar Indometasin. Jurnal Kedokteran Brawijaya. 2011; 26(3): 166-170.

Singh N, Verma P, Pandey BR, Bhalla M. Therapeutic Potential of Ocimum sanctum in Prevention and Treatment of Cancer and Exposure to Radiation: An Overview. International Journal of Pharmaceutical Sciences and Drug Research. 2012; 4(2): 97-104.

Hemalatha R, Babu K, Karthik M., Ramesh R., Kumar B. and Kumar P. Immunomodulatory Activity and Th1/Th2 Cytokine Response of Ocimum sanctum in Myelosuppressed Swiss Albino Mice. Trends in Medical Research. 2012 ; 6(1): 23-31.

Kim Y, Seo JH, and Kim H. β-Carotene And Lutein Inhibit Hydrogen Peroxide-Induced Activation Of NF-ΚB And IL-8 Expression In Gastric Epithelial AGS Cells. Journal of nutritional science and vitaminology. 2011;57(3):216–223.




DOI: http://dx.doi.org/10.21776/ub.jkb.2020.031.01.10

Refbacks

  • There are currently no refbacks.