Keseimbangan Sitokin Th1/Th2 Berperan Dalam Proliferasi Mastosit Jaringan Paru Pasca Pemberian Diet Tinggi Lemak pada Tikus
DOI:
https://doi.org/10.21776/ub.jkb.2009.025.01.3Abstract
ABSTRACTAsthma and obesity are prevalent disorders, each with a significant public health impact, and a large and
growing body of literature suggests an association between the two. The systemic inflammatory milieu in
obesity leads to metabolic and cardiovascular complications but this environment alters asthma risk or
phenotype is not yet known. Studies that evaluated the effects of leptin and obesity on airway inflammation
in response suggest that air way inflammation is enhanced by leptin. Leptin is stimulate a Th1 cytokine
profile and suppresses Th2 cytokine production. Whether resistance to the effects of the lung or on immune
function is unknown, but such resistance might be expected to polarize to a Th2. The aim of this study is
identify effect of leptin to lung mast cell proliferation via shifting Th1/Th2 balance using diet-induced obese
mice. Because there are contradictive between leptin immune function in leptin deficient and obese, to
understand the effect of leptin in diet-induced obese mice on immune function, lung mast cell proliferation
and correlation with IL-4 as represent cytokine Th2 and IL-2 represent cytokine Th1 has been studied.
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DAFTAR KEPUSTAKAAN
Schachter LM, Salome CM. Obesity is a risk for asthma and wheeze but not hyperresponsiveness. Thorax. 2001;56:46-482. Weiss T, Shore S. Obesity and Asthma Direction for Research. Am J Resp Crit Care Med. 2004;169:963-968
Beuther DA, Weiss T, and Sutherland. Obesity and asthma. Am J Respir Crit Care Med .2006;17:112119
Fantuzzi G, Faggioni. Leptin in the regulation of immunity, inflammation, and hematopoesis. Journal of leucocyte Biology. 2000;68
Sood A, Ford ES, Camargo CA. Association between leptin and asthma in adults.Thorax. 2006;61:300-305
Lord G M, Matarese G, Howard JK, Baker RJ, Bloom SR, Lechler RI. Leptin modulates the T-cell immune response and reverses starvation- induced immunosuppression. Nature. 1998;394:897
Pacifico L, Di Renzo, Anania C, Osborn F, Ippoliti FS, Chiesa C . Increased T-helper interferon secreting cells in obese children. European Journal of Endocrinology. 2006;154(5);691-697
Georas J Guo U De Fanis Casolaro . V T-helper cell type-2 regulation in allergic disease. Eur Respir J. 2005;26:1119-1137
Steinman L, Conlon P, Maki R, Foster A. The intricate interplay among body weight, stress, and the immune response to friend or foe. J. Clin. Invest. 2003;111:183-185
Vieira VJ, Ronan AM, Windt M, R Tagliaferro. Elevated atopy in healthy obese women .Am.J.Clin.Nutrition. 2005;82:503-508
Bischoff SC, Sellge G, Lorentz A, Sebald W, Raab R, Manns MP. IL-4 enhances proliferation and mediator release in mature human mast cells. Proc Natl Acad Sci. 1999;96(14):80805
Mountage Ct, Prins JB, Sanders L, Digby et al. sex specific difference in human leptin mRNA expression implication for the control of regional fat distribution. Diabetes;1997;46:342-347
El Haschimi K, Plerozz DD, Hileman, Bjorbaek C, Filler JS. Two defects contribute to hypoyhalamic resistance in mice with diet induce obesity. J Clin Invest. 2000;105:1827-1832,
Rosicka M, Krsek M, Moutulek M, et al. Serum Ghrelin levels in obese patient:There relationship to serum leptin levels and soluble leptin reseptor Levels. Physiol Res. 2003;52:61-66
Knudson JD, Dincer D, Zhang C, Swafford A. Leptin receptors are expressed in coronary arteries, and hyperleptinemia causes significant;2005
Papathanassoglou E, Li XC, Matarese G, Strom T, Montzzoros C,. Leptin receptor expression and signaling in lymphocytes: kinetics during lymphocyte activation, role in lymphocyte survival, and response to high fat diet in mice. The Journal of Immunology. 2006;176: 7745-7752.
Cunningham. Evaluation of the effects of nutrients on immune function in nutrition and immune function. Frontiers in nutritional science:1.Ed Calder, CJ Field; 2002
Devereux G. The immune system in nutrition and immune function. Frontiers in nutritional science:1.Ed Calder, CJ Field, 2002
Shamshiev, Rohrer, Marsland B, Kopf M. Dyslipidemia inhibits Toll-like receptorinduced activation of CD8á-negative dendritic cells and protective Th1 type immunity. JEM. 2007;204(2):441452
Tartaglia LA, Dembski M, Weng X, Deng W, Culpepper J, Devos R. Identification and expression cloning of leptin receptor. OB-R. Cell. 1995;83:1263-1271
Fei H, Okano HJ, Li C, Lee GH, Zhao C, Darnell R, and Friedman J M. Prod. Natl. Acad. Sci., U. S.A 1997;94:7001-7005
Devos R, Guisez Y, Van der HJ, et al. Ligand- independent dimerization of the extracellular domain of the leptin receptor and determination of the stoichiometry of leptin binding. J. Biol. Chem. 1997;272:1830418310
Couturier C, Jockers R. Activation of the leptin receptor by a ligand-induced conformational change of constitutive receptor dimers.J. Biol. Chem. 2003;26604-26611
Lord GM, G Matarese, J K Howard, S R Bloom, RI Lechler. Leptin inhibits the anti-CD3-driven proliferation of peripheral blood T cells but enhances the production of proinflammatory cytokines. J. Leukocyte Biol. 2002;72:330.
Guler N, Kirerleri E, Ones U, et al. Leptin: Does have any role in childhood asthma? . J Allergy Clin Immunol. 2005;115:103-109
Kondo N, Matsui E, Kaneko H, et al. Atopy and mutations of IL-12 receptor beta 2 chain gene. Clin Exp Allergy. 2001;31: 11891193.
Ozaki, Yoh-ichi S, Fukushima A,Masato K. The control of allergic conjunctivitis by suppressor of cytokine signaling (socs)3 and socs5 in a murine model. The Journal of Immunology. 2005;175:54895497.
Farooqi, Matarese, Lord, et al. Beneficial effects of leptin on obesity, t cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. Clin. Invest.2002;110:1093-1103
Kinoshita T, Sawai N, Hidaka E, Yamashita T, Koike K. Interleukin-6 directly modulates stem cell factor-dependent development of human mast cells derived from CD34(+) cord blood cells. Blood. 1999;94(2):496508.
Canfield S, Lee C, Schro¨der A ,Rothman P. The cutting edge: il-4 induces suppressor of cytokine signaling-3 expression in b cells by a mechanism dependent on activation of p38 mapk1. Journal of Immunology. 2005;174:24942498
Hristova M, Aloe L, Ghenev P, Fiore M, Chadalkove G. Leptin and mast cell; a novel adipoimmune link Turk J Med Sci. 2001;31:581-583
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