Pemberian Kombinasi Vitamin C dan E Peroral Memperbaiki Kerusakan Hepar Akibat Paparan Rokok Kretek Sub Kronik

Authors

  • I Ketut Gede Muliartha Laboratorium Patologi Anatomi Fakultas Kedokteran Universitas Brawijaya
  • Endang Sriwahyuni Laboratorium Ilmu Faal Fakultas Kedokteran Universitas Brawijaya
  • Yuliawati Yuliawati Program Studi Pendidikan Dokter Fakultas Kedokteran Universitas Brawijaya

DOI:

https://doi.org/10.21776/ub.jkb.2009.025.01.5

Abstract

ABSTRACT
Free radicals in cigarette smoke can destroy tissue and cells of the body. The activity of free radicals can be
reduced by antioxidants from external and internal. The objective of this research is to investigate the effects
of vitamin C and vitamin E combination on the histopathology of rat liver exposed by subcronic cigarette
smoke. This research using true experimental study with post test only control group design. The sample o
this research we used 32 Wistar rat, ages between 2-3 months, weight 150-200 grams divided 8 grouped
Cigarette smoke exposed for 10 weeks. Parameter will be measured is the number of liver cells damage
(necrosis). Data analysis uses the One-Way ANOVA method followed by Turkey test. The result show the
number of liver cells damage are significantly decrease. The conclution vitamin C and vitamin E combination
decrease the number of the liver cells damage of the rat liver, that has been exposed to subcronic cigarette
smoke at optimal doze 0,20 mglg bw vitamin C and 0,04 lUlg bw vitamin E.
Keywords: vitamin C, vitamin E, cigarette smoke, liver cells damage.

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References

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Issue

Vol. 25 No. 1 (2009)

Section

Original Article

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