Hormonal vs. Non-Hormonal Contraceptives for Women in Relation to Cervical Cancer: A Systematic Review
DOI:
https://doi.org/10.21776/ub.jkb.2025.033.03.7Keywords:
Cervical cancer, hormonal contraception, non-hormonal contraceptionAbstract
Recent global statistics indicate approximately 527,624 new cases of cervical cancer and 265,672 deaths annually. Additionally, recent research has identified a correlation between cervical cancer incidence and the use of hormonal or non-hormonal contraceptives. This systematic review aims to investigate this correlation. Articles meeting inclusion criteria from Google Scholar and PubMed within the last five years were searched. Eight eligible studies were included: six on hormonal contraceptives and two on non-hormonal contraceptives. The review findings suggest that the use of both non-hormonal and hormonal contraceptives increases the risk of cervical cancer. Non-hormonal contraception was associated with a slightly elevated risk, while hormonal contraceptives, especially oral contraceptive tablets used over an extended period, showed a clear link to increased cervical cancer risk.
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References
1. Cohen PA, Jhingran A, Oaknin A, and Denny L. Cervical Cancer. Lancet. 2019; 393(10167): 169–182.
2. Bedell SL, Goldstein LS, Goldstein AR, and Goldstein AT. Cervical Cancer Screening: Past, Present, and Future. Sexual Medicine Reviews. 2019; 8(1): 28–37.
3. Kementerian Kesehatan RI. Indonesia Demographic and Health Survey 2017. Jakarta: Kemenkes RI; 2018.
4. Brabaharan S, Veettil SK, Kaiser JE, et al. Association of Hormonal Contraceptive Use with Adverse Health Outcomes: An Umbrella Review of Meta-analyses of Randomized Clinical Trials and Cohort Studies. JAMA Network Open. 2022; 5(1): 1-19.
5. Ernawati H, Mas'udah AF, Emilia O, Lusmilasari L, Isroin L, and Verawati M. The Use of Contraception and Adolescent Fertility in Indonesia. Open Access Macedonian Journal of Medical Sciences. 2021; 9(G): 168–171.
6. Gafar A, Suza DE, Efendi F, Has EMM, Pramono AP, and Susanti IA. Determinants of Contraceptive Use among Married Women in Indonesia. F1000Research. 2020; 9: 1-9.
7. Badan Kependudukan dan Keluarga Berencana Nasional. Laporan Kinerja BKKN 2018. Jakarta: Badan Kependudukan dan Keluarga Berencana Nasional; 2018.
8. Minalt N, Caldwell A, Yedlicka GM, et al. Association between Intrauterine Device Use and Endometrial, Cervical, and Ovarian Cancer: An Expert Review. American Journal of Obstetrics and Gynecology. 2023; 229(2): 93–100.
9. Zhang S, Xu H, Zhang L, and Qiao Y. Cervical Cancer: Epidemiology, Risk Factors and Screening. Chinese Journal of Cancer Research. 2020; 32(6): 720–728.
10. Ginsburg O, Bray F, Coleman MP, et al. The Global Burden of Women's Cancers: A Grand Challenge in Global Health. The Lancet. 2017; 389(10071): 847–860.
11. Iversen L, Fielding S, Lidegaard Ø, and Hannaford PC. Contemporary Hormonal Contraception and Cervical Cancer in Women of Reproductive Age. International Journal of Cancer. 2021; 149(4): 769–777.
12. Hull R, Mbele M, Makhafola T, et al. Cervical Cancer In Low and Middle‑Income Countries (Review). Oncology Letters. 2020; 20(3): 2058–2074.
13. Gul S, Ali T, Bibi R, Hanif S, Gul S, and Farooqi K. Association Between Hormonal Contraceptives and Cervical Neoplasia in Local Population of Khyber Pakhtunkhwa. Pakistan Journal of Medical & Health Sciences. 2022; 16(9): 489–491.
14. Keogh SC, Otupiri E, Castillo PW, et al. Hormonal Contraceptive Use in Ghana: The Role of Method Attributes and Side Effects in Method Choice and Continuation. Contraception. 2021; 104(3): 235–245.
15. Arfailasufandi R, Mudigdo A, and Sudiyanto A. The Effect of Obesity, Oral Contraceptive and Passive Smoking on the Risk of Cervical Cancer. Journal of Epidemiology and Public Health. 2019; 4(3): 189–197.
16. Kehiosh HJ, Dakhal HJ, Khudhair ES, Alsafi W, Abaid SS, and Abutiheen AA. The Effect of Intrauterine Contraceptive Device and Oral Contraceptive Pills Use on Pap Smear Results. The Thi-Qar Medical Journal. 2021; 20(2): 161–172.
17. Loopik DL, IntHout J, Melchers WJG, Massuger LFAG, Bekkers RLM, and Siebers AG. Oral Contraceptive and Intrauterine Device Use and the Risk of Cervical Intraepithelial Neoplasia Grade III or Worse: A Population-Based Study. European Journal of Cancer. 2020; 124: 102–109.
18. Trifitriana M, Sanif R, Husin S, and Mulawarman R. Risk Factors of Cervical Cancer in Outpatient and Inpatient at Obstetric and Gynecology RSUP Dr. Mohammad Hoesin Palembang. MEDICINUS: Jurnal Kedokteran Universitas Pelita Harapan. 2019; 8(3): 133-140.
19. Zin NDM, Ismail TAT, and Hashim N. Factors Associated with Presence of Human Papillomavirus Infection among Women: Findings from New Cervical Cancer Screening in Kelantan, Malaysia. Malaysian Journal of Medicine and Health Sciences. 2023; 19(4): 84–92.
20. Zuwariah N, Amalia R, and Ainiyah S. Cervical Cancer Incidence Correlation with Hormonal Contraceptive Use. Jurnal Ilmiah Kesehatan (Journal of Health Sciences). 2021; 14(1): 63–67.
21. Do Rozario S, da Silva IF, Koifman RJ, and Silva IF. Characterization of Women with Cervical Cancer Assisted at Inca by Histological Type. Revista de Saúde Pública. 2019; 53: 1-12.
22. Asthana S, Busa V, and Labani S. Oral Contraceptives Use and Risk of Cervical Cancer—A Systematic Review & Meta-Analysis. European Journal of Obstetrics and Gynecology and Reproductive Biology. 2020; 247: 163–175.
23. Okunade KS. Human Papillomavirus and Cervical Cancer. Journal of Obstetrics and Gynaecology: The Journal of the Institute of Obstetrics and Gynaecology. 2020; 40(5): 602–608.
24. Bohannan JC, Nixon E, Campanelli-Spence A, and Kriegsman W. Is There Any Difference in Risk of Cervical Dysplasia and Cervical Cancer Between Users of Copper IUDs and Other IUDs? Evidence-Based Practice. 2020; 23(6): 10–11.
Cortessis VK, Barrett M, Wade NB, et al. Intrauterine Device Use and Cervical Cancer Risk: A Systematic Review and Meta-analysis. Obstetrics & Gynecology. 2017; 130(6): 1226–1236.
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