Iron Status of Newborns and Umbilical Cord Blood Hepcidin Levels in Gender Differences

Authors

  • Qodri Santosa University of Jenderal Soedirman
  • AG Soemantri University of Diponegoro
  • Soeharyo Hadisaputro University of Diponegoro
  • Ariawan Soejoenoes University of Diponegoro

DOI:

https://doi.org/10.21776/ub.jkb.2020.031.01.12

Keywords:

Fetal gender, hepcidin, iron status, newborn, sTfR

Abstract

Fetal gender might affect the iron status of newborns. Hepcidin has an important role in the process of maternofetal iron transport. This study aims to compare the newborn iron status and the umbilical cord hepcidin levels between male and female gender. A cross-sectional study was conducted with subjects of 84 clinically healthy newborns. Written informed consent and ethical approval were carried out. Newborn iron status observed included (i) hematologic markers (RBC count, Hb, hematocrit, mean corpuscular volume (MCV) and red cell distribution width), and (ii) biochemical markers (serum iron (SI), serum ferritin (SF), soluble transferrin receptor (sTfR) and cord blood hepcidin). Hematologic markers were checked using Sysmex, XN-1000, while Hepcidin and sTfR were using ELISA. Serum iron was checked using IRON Flex®. Statistical analysis was tested with the independent t-test and the Mann-Whitney. All newborns and their mothers were in normal condition. The mean sTfR levels of newborns were significantly higher in the male group than females (38.3±9.06 vs. 34.3±8.16 nmol/L) with p=0.033. High sTfR levels reflect a low iron status. In conclusion, fetal gender differences influence the iron status of newborns, and male newborns have a potentially higher iron deficiency.

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Author Biographies

Qodri Santosa, University of Jenderal Soedirman

Department of Pediatrics, Faculty of Medicine, University of Jenderal Soedirman

AG Soemantri, University of Diponegoro

Department of Pediatrics, Faculty of Medicine, University of Diponegoro

Soeharyo Hadisaputro, University of Diponegoro

Departement of Public Health, Faculty of Medicine, University of Diponegoro

Ariawan Soejoenoes, University of Diponegoro

Department of Obstetrics and Gynecology, Faculty of Medicine, University of Diponegoro

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Published

2020-02-29

Issue

Vol. 31 No. 1 (2020)

Section

Research Article

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