Karboksimetil Kitosan Menurunkan Degranulasi Mast Cell yang Diinduksi Oleh Ovalbumin
DOI:
https://doi.org/10.21776/ub.jkb.2009.025.01.2Abstract
ABSTRACTOvalbumin is known as mast cell degranulating agent through the FCεRI aggregation. Carboxymethyl
chitosan (CMCs), a biocompatible cationic polymer was evaluated to reduces mast cell degranulation induced
by ovalbumin. In this experiment, wistar rats were d
arboxymethyl chitosan
ivided into 5 groups which consist of 1 control group and 4
allergen groups. Among the allergen groups, 3 groups were treated with carboxymethyl chitosan/CMCs
(doses : 0,25 mg, 0,50 mg and 1,00 mg) for 22 days. The result showed a significant (P<0,01) reduction in
mast cell degranulation in allergen groups. This finding indicate that CMCs possesses antiinflammation
activity mediated by reducing of mast cell degranulation.
Keywords : ,c mast cell degranulation
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