Suplementasi Ekstrak Bilberry Menurunkan Kadar Malondialdehid Lensa Penderita Katarak Senilis

Authors

  • T Budi Sulistya
  • Alfi Mutamimma

DOI:

https://doi.org/10.21776/ub.jkb.2011.026.04.3

Abstract

Salah satu faktor yang berperan pada katarak senilis adalah stres oksidatif. Penelitian ini bertujuan untuk mengevaluasi pengaruh ekstrak bilberry untuk mengurangi kadar malondialdehid lensa katarak senilis. Uji klinis tersamar ganda dilakukan dengan 33 orang pasien katarak senilis. Subjek dibagi menjadi 3 kelompok secara merata yaitu plasebo, perlakuan 100 mg ekstrak bilberry dan 300 mg ekstrak bilberry. Pengobatan yang diberikan sampai 14 hari sebelum operasi katarak untuk mengevaluasi tingkat malondialdehid. Data dianalisis menggunakan ANOVA dan uji Tukey. Tingkat rata-rata malondialdehid di kelompok plasebo, ekstrak bilberry 100 mg, dan 300mg adalah 11,82± SD 2,96 nmol/mg, 7,99±SD1,99 nmol/mg, dan 5,22±1,27SD nmol/mg. Efek penurunan malondialdehid dengan pemberian 100 mg dan 300 mg ekstrak bilberry berbeda signifikan (p<0,05). Terdapat korelasi negatif antara ekstrak bilberry dan malondialdehid tergantung dosis (r=-0,760; p<0,001). Diagram menunjukkan bahwa peningkatan dosis ekstrak bilberry akan mengakibatkan penurunan tingkat malondialdehid pada pasien katarak senilis. Dapat disimpulkan bahwa pemberian ekstrak suplemen bilberry dapat mengurangi kadar malondialdehid di lensa pasien katarak senilis dan peningkatan dosis ekstrak bilberry berkorelasi dengan tingkat penurunan malondialdehid pada lensa penderita katarak senilis.
Kata Kunci: Ekstrak bilberry, katarak senilis, malondialdehid

Downloads

Download data is not yet available.

References

El-Ghaffar A, Aziz MA, Mahmoud AM, and Al Balkini SM. Elevation of Plasma Nitrate and Malondialdehyde in Patients with Aged Related Cataract. Middle East African Journal of Ophthalmology. 2007; 14(1): 13-15.

Mirsamadi M, Nourmohammadi I, and Imamian M. Comparative Study of Serum Na+ and K+ levels in Senile Cataract Patients and Normal Individual. International Journal of Medical Sciences. 2004; 1: 165-169.

American Academy of Opthalmology Staff. Lens and Cataract. Basic and Clinical Course. Section 11. San Francisco: American Academy of Opthalmology; 2008-2009: p. 16-17,71-74

Menteri Kesehatan Repubik Indonesia. Rencana Strategi Nasional Penanggulangan Gangguan Penglihatan dan Kebutaan untuk Mencapai Vision 2020. [Keputusan Menteri]. Jakarta. 2005.

Taylor HR. Cataract: How Much Surgery do We Have To Do? . British Journal of Opthalmology. 2000; 84: 1-2

Pramono. Setiap Menit Satu Anak menjadi Buta. (Online) 2007. http://www.tempointeractive.com /hg/nasional/2007/10/12/brk,20071012-109482 ,id.html

National Eye Institute. Cataract. (Online) 2009. http://www.nei.nih.gov/health/cataract/cataract_facts.asp.

Pelman JAM, Lely BJ, Klein R, et al. Vitamin Supplement Use and Incident Cataracts in a Population Based Study. Archives of Ophthalmology. 2000; 118(11): 1556-1563.

Ates NA, Yildirim O, Tamer L, et al. Plasma Catalase Activity and Malondialdehyde Level in Patients with Cataract. Eye. 2004; 18: 785-788.

Head K. Natural Therapies for Ocular Disorders. Part Two: Cataract and Glaucoma. Alternative Medical Review. 2001; 6(2): 142-145.

Palmieri B and Sblendorio V. Oxidative Stress Tests: Overview on Reliability and Use. Part 1. European Review for Medical and Pharmacological Sciences. 2007; 11(5): 309-342.

Varma SD. Scientific Basis for Medical Therapy of Cataracts by Antioxidants. American Journal Society for Clinical Nutrition. 1991; 53: 335-345.

Saygili EI, Aksoy SN, Gurler B, Akson A, Erel O, and Ozaslan M. Oxidant/Antioxidant Status of Patient with Diabetic and Senile Cataract. Biotechnology & Biotechnological Equipment. 2010; 24(1): 1648-1652.

Brown, NP. Mechanism of Cataract Formation. Journal of Optometri. 2001; 3(4): 21-31.

Droge W. Free Radical with the Physiological Control of All Function. Physiological Reviews. 2008; 82(1): 47-95.

Wahyu L dan Gondowiardjo TD. Efek Suplementasi Vitamin C dan E terhadap Stres Oksidatif pada Lensa Katarak. Majalah Opthalmology Indonesia. 2004; 31(3): 194-200.

Seth RK and Kharb S. Protective Function of Alpha-tocopherol Against the Process of Cataractogenesis in Human. Annals of Nutrition and Metabolism. 1999; 435: 286-289.

Thohir A, Sulistya TB, dan Santoso SA. Efek Suplementasi Ekstrak Bilberry terhadap Kadar Malondialdehid Lensa Tikus yang Dipapar Radiasi Cranium Total. [Thesis]. Univesitas Brawijaya Malang, Malang. 2008.

Spector A. Oxidative Stress-Induced Cataract: Mechanism of Action. The Federation of American Societies for Experimental Biology Journal. 1995; 9: 1173-1180

Yao N, Fan L, He RR, and Kurihara H. Protective Effect of Bilberry (Vaccinium Myrtilus) Extract Againts Endotoxin Induce Uveitis in Mice. Journal of Agricultural and Food Chemistry. 2010; 58(8): 4731-4736.

Lee J, Lee HK, Kim CY, et al. Purified High-dose Anthocyanoside Oligomer Administration Improves Nocturnal Vision and Clinical Symptoms in Myopia Subjects Institute of Vision Research. British Journal of Nutrition. 2007; 93: 895-899.

Antal DS, Garban G, and Garban Z. The Anthocyans: Biologically-Active Substance of Food and Pharmaceutic Interest. The Annals of the University Dunarea de Jos of Galati. 2003; 6(106): 106-116.

Downloads

Issue

Vol. 26 No. 4 (2011)

Section

Original Article

License

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).