PEMBERIAN ETANOL JANGKA PANJANG MENURUNKAN MEMORI KERJA SPASIAL PADA TIKUS

Authors

  • Soedjono Aswin Bagian Anatomi Fakultas Kedokteran Universitas Gadjah Mada
  • Mustofa Mustofa Bagian Farmakologi Fakultas Kedokteran Universitas Gadjah Mada

DOI:

https://doi.org/10.21776/ub.jkb.2008.024.02.7

Abstract

Long term ethanol administration may cause morphological changes in the hippocampus, followed by deficit
in  the  hippocampal  function  including  the  impairment  of  memory.  The  aim  of  this  study  is  to  investigate  the
changes of spatial working memory of rats after chronic ethanol administration at adolescent age. Twenty five
adolescent  (30  days  of  age)  male  rats  (Rattus  novergicus)  divided  randomly  into  5  groups  :  control  without
treatment (C1), control with treatment (C2), treatment 1 (T1), treatment 2 (T2), treatment 3 (T3) group. Each
group consist of 5 rats. C2 group was given physiologic saline, T1, T2, and T3 group were given ethanol with
doses  1,  2,  and  3  g/kg/day  for  30  days  by  intraperitoneal  injection.  After  chronic  ethanol  administration  the
spatial  working  memory  of  5  groups  were  tested  by  using  8  arm  radial  maze  for  12  days.  Spatial  working
memory measured by total number of entered arm maze and error A type. The results of this study showed
that  chronic  ethanol  administration  at  adolescent  age  caused  decreasing  of  spatial  working  memory  of  the
rats. The total number of entered arms maze and error A type for treatment group (especially P3 ) is higher
than  control  groups  (p<0,05).  It  is  concluded  that  in  rats,  chronic  ethanol  administration  at  adolescent  age
caused decreasing spatial working memory.   
Key words : Ethanol, Spatial working memory, Adolescent

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References

DAFTAR KEPUSTAKAAN

Djatmiko, P, Berbagai Indikator Taraf Kesehatan Jiwa Masyarakat. htpp://pdskjijaya.org/index.php?option=com_content&task=view&id=110&itemid=1, 7 Desember 2007.

Spear, L. P. The Adolescent Brain and The College Drinker : Biological Basis of Propensity to Use and Missuse Alcohol. Journal of Studies on Alcohol. 2002;14:71-81.

Zeigler, D. W., Wang, C. C., Yoast, R. A., Dickinson, B. D.,McCaffree, M. A.,Robinowitz,C. B., et al. The

Neurocognitive Effects of Alcohol on Adolescents and College Students. Preventive Medicine. 2005; 40 : 23-32.

Ballinger, A. and Patchett, S. Poisoning, Drug and Alcohol Abuse. Saunders Pocket Essentials of Clinical Medicine. 4th edition, London; W.B. Saunders Company, 1995.

Mikolajczak, P., Kozaryn, I., Nowaczyk, M. and Kaminska, E. Ethanol Facilitation Short-Term Memory in Adult Rats with a Disturbed Circadian Cycle. Alcohol & Alcoholism. 2001;36(4):292-97.

Ling, W., Compton, P., Rawson, R. and Wesson, D. R. Neuropsychiatry of and Drug Abuse. Neuropsychiatry, 2

nd edition, Philadelpia; Lippincott Williams & Wilkins,2003

Matthews, D. and Morrow, Effects of Acute and Chronic Ethanol Exposure on Spatial Cognitive Processsing and Hippocampal Function in The Rat. Hippocampus,2000;10:122-30.

Marino, D. M., Aksenov, M. Y. and Kelly, S. J. Vitamine E Protects Against Alcohol-induced Cell Loss and Oxidative Stress in Neonatal Rat Hippocampus. Int. J. Devl. Neurosci,2004;22:363-77.

Hampton, R. R., and Shettleworth, S. J. Hippocampal Lesions Impair Memory for Location but not Color in Passerine Birds. Behavioral Neuroscience, 1996;110(4):831-35.

Ropper, A. H. and Brown, R. H. and Alcoholism & Dimentia and The Amnestic Syndrome. Adam’s and Victor’s Principles of Neurology, 8th edition, New York, McGraw-Hill Companies Inc, 2005.

Seamans, J. K., Floresco, S. B. and Phillips, A. G. D1 Receptor Modulation of Hippocampal-Prefrontal cortical circuits Integrating Spatial memory with Executive Function in The Rat. J. Neurosci., 1998;18(4) : 1613-21.

Dogru,E.J., Gumusbas, U. and Kara, F. Individual Variation in the Spatial Reference and Working Memory

Assassed under Allothetic and Idiothetic Orientation Cues in Rat, Acta Neurobiol. Exp., 2003;63 : 17-23.

Spear, L. P. Alcohol’s Effects on Adolescent. Alcohol Research & Health, 2002; 26(4): 287-91.

Farr, S. A., Scherrer, J. F., Banks, W. A., Flood, J. F. and Morley, J. E. Chronic Ethanol Consumption Impairs

Learning and Memory after Cessation of Ethanol. Alcoholism Clinical and Experimental Research, 2005; 29 (6) : 9711-82.

Markwiese,B. J., Acheson, S. K., Levin, E. D., Wilson, W. A. and Swartzwenlder,H.S.Differential Efffects of Ethanol on Memory in Adolescent and Adult Rats. Alcoholism Clinical and Experimental Research, 1998; 22 (2) :416-21.

Sturmhofel, S. H. Swartzwelder, H. S. Alcohol’s Effects on the Adolescent Brain. Alcohol Research & Health, 2004;28 (4):213-21.

Roberto, M., Nelson, T. E., Ur, C. L and Gruol, D. L. Long-Term Potentiation in The Rat Hippocampus is Reversibly Depressed by Chronic Intermittent ethanol exposure. J. Neurophysiol,2001;87:2385-97.

Franke,H.,Kittner,H.,Berger,P.,Wirkner, K. And Schramek, J. The Reaction of Astrocytes and Neurons in

The Hippocampus of Adult Rats During Chronic Ethanol Treatment and Correlations to behavioral Impairments. Alcohol,1997; 14(5): 445-54

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Published

2013-03-11

Issue

Vol. 24 No. 2 (2008)

Section

Research Article

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