Pengaruh Vitamin D terhadap Ekspresi COX-2, Kadar cAMP, Kadar Renin Darah dan Tekanan Darah Sistolik dalam Sistem Renin Angiotensin Aldosteron
DOI:
https://doi.org/10.21776/ub.jkb.2016.029.02.5Abstract
Banyak penelitian yang melaporkan hubungan antara kadar vitamin D dalam darah dengan hipertensi, hanya saja mekanismenya dalam sistem renin angiotensin belum dapat dijelaskan dengan pasti. Hal ini yang menarik untuk mempelajari mekanisme aksi vitamin D dalam dalam pengaturan tekanan darah di sistem renin angiotensin aldosteron. Rancangan penelitian ini adalah eksperimen laboratorik dengan pre-post test group design, yang di bagi menjadi dua tahap. Tahap pertama untuk mempelajari pengaruh vitamin D terhadap ekspresi COX-2 di sel macula densa ginjal dan tahap kedua untuk mempelajari mekanisme aksi vitamin D dalam pengaturan tekanan darah. Hasil yang di dapat bahwa sasaran aksi vitamin D pada sistem renin angiotensin aldosteron kemungkinan ada di dua bagian, yaitu ada yang di bagian up-stream cAMP dengan menekan ekspresi COX-2 di sel macula densa ginjal dan ada yang di bagian down-stream cAMP, yaitu dengan menekan langsung gen yang menyandi renin. Hal ini didukung dengan data bahwa tidak terjadinya akumulasi cAMP, peningkatan kadar renin dan TDS walaupun hewan coba telah diberi teofilin bersamaan dengan vitamin D.
Kata Kunci: hipertensi, vitamin D, renin, cAMP, COX-2 dan tekanan darah sistolik
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Ong KL, Cheung BM, Man YB, Lau CP, and Lam KS. Prevalence Awareness, Treatment, and Control of Hypertension among US Adults 1999-2004. Hypertension. 2007; 49(1): 69-75.
Ma J and Stafford RS. Screening, Treatment and Control of Hypertension in US Private Physician Officer 2003-2004. Hypertension. 2008; 51(5): 1275-1281.
Lilova M. Hypertension in Children with Chronic Renal Failure. The Turkish Journal of Pediatrics. 2005; 47: 28-31.
Li YC. Vitamin D Regulation of the Renin Angiotensin System: Mechanism and Implication. Journal of Cellular Biochemistry2003; 88(2): 327-331.
Yuan W, Pan W, Kong J, et al. 1,25-Dihydroxyvitamin D3 Suppresses Renin Gene Transcription by Blocking the Activity of the Cyclic AMP Response Element in the Renin Gene Promoter. Journal of Biological Chemistry. 2007; 282(41): 29821-29830.
Rostand SG. Ultraviolet Light May Contribute to Geographic and Racial Blood Pressure Differences. Hypertension. 1997; 30(2): 150-156.
Forman JP, Giovannucci E, Holmes MD, et al. Plasma 25-Hydroxyvitamin D Levels and Risk of Incident Hypertension. Hypertension. 2007; 49(5): 1063-1069.
Martini LA and Wood RJ. Vitamin D and Blood Pressure Connection: Update on Epidemiologic, Clinical, and Mechanistic Evidence. Nutrition Reviews. 2008; 66(5): 291-297.
Li YC, Kong J, Wei M, Chen ZF, Liu SQ, and Cao LP. 1,25-Dihydroxyvitamin D(3) is a Negative Endocrine Regulator of the Renin-Angitensin System. The Journal of Clinical Investigation. 2002; 110(2): 229-238.
Krishnan AV and Feldman D. Molecular Pathway Mediating the Anti-Inflammatory Effect of Calcitriol: Implication for Prostate Cancer Chemoprevention and Treatment. Endocrine-related Cancer. 2010; 17(1): R19-R38.
Hermawan D, Kadarsih S, Sunarti, Astuti I, and Agus ZAN. Efek Asupan Vitamin D terhadap Tekanan Darah Sistolik Tikus Putih (Rattus norvegicus). Jurnal Gizi Klinik Indonesia. 2012; 9(1): 10-15.
Weng S, Sprague JE, Oh J, et al. Vitamin D Deficiency Induces High Blood Pressure and Accelerates Atherosclerosis in Mice. PLoS One. 2013; 8(1): es4625.
Harris RC. COX-2 and Kidney. Journal of Cardiovascular Pharmacology. 2006: 47: S37-S42.
Swami S, Krishnan AV, Moreno J, Bhattacharyya RB, Peehl DM, and Feldman D. Calcitriol and Genistein Action to Inhibit the Prostaglandin Pathway: Potential Combination Therapy to Treat Prostate Cancer. Journal of Nutrition. 2007; 137(1): 205S-210S.
Aparna R, Subhashini J, Roy KR, et al Selective Inhibition of Cyclooxygenase-2 (COX-2) by 1 α, 25-Dihydroxy-16-ene-23-yne-Vitamin D3, a Less Calcemic Vitamin D Analog. Journal of Cellular Biochemistry. 2008; 104(5): 1832-1842.
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