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IgM-RF pada Anak Terinfeksi Virus Dengue Tidak Berkorelasi dengan Jumlah Trombosit dan Hematokrit

Safari Wahyu Jatmiko, Lisyani Suromo, Edi Dharmana
  Jurnal Kedokteran Brawijaya, Vol 29, No. 4 (2017),  pp.306-311  

Abstract


Banyak teori diajukan untuk menjelaskan patogenesis trombositopenia dan hemokonsentrasi pada Infeksi Virus Dengue (IVD), termasuk teori autoimun. Hal ini menimbulkan pertanyaan apakah Rheumatoid Factor (RF) yang biasa ditemukan pada pasien autoimun juga ditemukan dan berhubungan dengan perubahan jumlah trombosit dan nilai hematokrit pada pasien IVD. Tujuan penelitian adalah untuk membuktikan hubungan RF dengan jumlah trombosit dan nilai hematokrit pada anak terinfeksi virus dengue. Desain penelitian menggunakan analisis korelatif dengan pendekatan belah lintang dilakukan terhadap 40 pasien yang mengalami demam minimal 4 hari dan memenuhi kriteria diagnostik IVD menurut WHO 2009, usia di bawah 14 tahun, dan diagnosis dikonfirmasi dengan antibodi antidengue. Pasien dengan riwayat penyakit autoimun dan riwayat immunocompromised dikeluarkan dari penelitian. Sampel diambil secara konsekutif. Darah rutin diperiksa penggunakan hematology analyzer sedangkan RF diperiksa dengan metode aglutinasi lateks. Data diolah dengan uji korelasi Spearman. Hasil penelitian menunjukkan pasien dengan RF (+) sebanyak 62,5%. Hasil uji korelasi RF dan jumlah trombosit menunjukkan nilai r=0,151 dengan p=0,354 sedangkan hasil uji korelasi RF dan nilai hematokrit nilai r=0,3 dengan p=0,06. Penelitian ini menunjukkan bahwa tidak terdapat korelasi antara kadar RF serum dengan jumlah trombosit pada pasien IVD dan antara kadar RF serum dengan nilai hematokrit pada pasien IVD, walaupun ada kecenderungan peningkatan kadar RF serum diiringi dengan kenaikan nilai hematokrit.


Keywords


Hematokrit, infeksi virus dengue, rheumatoid factor, trombosit

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