PEMBERIAN ETANOL JANGKA PANJANG MENURUNKAN MEMORI KERJA SPASIAL PADA TIKUS
DOI:
https://doi.org/10.21776/ub.jkb.2008.024.02.7Abstract
Long term ethanol administration may cause morphological changes in the hippocampus, followed by deficitin the hippocampal function including the impairment of memory. The aim of this study is to investigate the
changes of spatial working memory of rats after chronic ethanol administration at adolescent age. Twenty five
adolescent (30 days of age) male rats (Rattus novergicus) divided randomly into 5 groups : control without
treatment (C1), control with treatment (C2), treatment 1 (T1), treatment 2 (T2), treatment 3 (T3) group. Each
group consist of 5 rats. C2 group was given physiologic saline, T1, T2, and T3 group were given ethanol with
doses 1, 2, and 3 g/kg/day for 30 days by intraperitoneal injection. After chronic ethanol administration the
spatial working memory of 5 groups were tested by using 8 arm radial maze for 12 days. Spatial working
memory measured by total number of entered arm maze and error A type. The results of this study showed
that chronic ethanol administration at adolescent age caused decreasing of spatial working memory of the
rats. The total number of entered arms maze and error A type for treatment group (especially P3 ) is higher
than control groups (p<0,05). It is concluded that in rats, chronic ethanol administration at adolescent age
caused decreasing spatial working memory. Â
Key words : Ethanol, Spatial working memory, Adolescent
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DAFTAR KEPUSTAKAAN
Djatmiko, P, Berbagai Indikator Taraf Kesehatan Jiwa Masyarakat. htpp://pdskjijaya.org/index.php?option=com_content&task=view&id=110&itemid=1, 7 Desember 2007.
Spear, L. P. The Adolescent Brain and The College Drinker : Biological Basis of Propensity to Use and Missuse Alcohol. Journal of Studies on Alcohol. 2002;14:71-81.
Zeigler, D. W., Wang, C. C., Yoast, R. A., Dickinson, B. D.,McCaffree, M. A.,Robinowitz,C. B., et al. The
Neurocognitive Effects of Alcohol on Adolescents and College Students. Preventive Medicine. 2005; 40 : 23-32.
Ballinger, A. and Patchett, S. Poisoning, Drug and Alcohol Abuse. Saunders Pocket Essentials of Clinical Medicine. 4th edition, London; W.B. Saunders Company, 1995.
Mikolajczak, P., Kozaryn, I., Nowaczyk, M. and Kaminska, E. Ethanol Facilitation Short-Term Memory in Adult Rats with a Disturbed Circadian Cycle. Alcohol & Alcoholism. 2001;36(4):292-97.
Ling, W., Compton, P., Rawson, R. and Wesson, D. R. Neuropsychiatry of and Drug Abuse. Neuropsychiatry, 2
nd edition, Philadelpia; Lippincott Williams & Wilkins,2003
Matthews, D. and Morrow, Effects of Acute and Chronic Ethanol Exposure on Spatial Cognitive Processsing and Hippocampal Function in The Rat. Hippocampus,2000;10:122-30.
Marino, D. M., Aksenov, M. Y. and Kelly, S. J. Vitamine E Protects Against Alcohol-induced Cell Loss and Oxidative Stress in Neonatal Rat Hippocampus. Int. J. Devl. Neurosci,2004;22:363-77.
Hampton, R. R., and Shettleworth, S. J. Hippocampal Lesions Impair Memory for Location but not Color in Passerine Birds. Behavioral Neuroscience, 1996;110(4):831-35.
Ropper, A. H. and Brown, R. H. and Alcoholism & Dimentia and The Amnestic Syndrome. Adam’s and Victor’s Principles of Neurology, 8th edition, New York, McGraw-Hill Companies Inc, 2005.
Seamans, J. K., Floresco, S. B. and Phillips, A. G. D1 Receptor Modulation of Hippocampal-Prefrontal cortical circuits Integrating Spatial memory with Executive Function in The Rat. J. Neurosci., 1998;18(4) : 1613-21.
Dogru,E.J., Gumusbas, U. and Kara, F. Individual Variation in the Spatial Reference and Working Memory
Assassed under Allothetic and Idiothetic Orientation Cues in Rat, Acta Neurobiol. Exp., 2003;63 : 17-23.
Spear, L. P. Alcohol’s Effects on Adolescent. Alcohol Research & Health, 2002; 26(4): 287-91.
Farr, S. A., Scherrer, J. F., Banks, W. A., Flood, J. F. and Morley, J. E. Chronic Ethanol Consumption Impairs
Learning and Memory after Cessation of Ethanol. Alcoholism Clinical and Experimental Research, 2005; 29 (6) : 9711-82.
Markwiese,B. J., Acheson, S. K., Levin, E. D., Wilson, W. A. and Swartzwenlder,H.S.Differential Efffects of Ethanol on Memory in Adolescent and Adult Rats. Alcoholism Clinical and Experimental Research, 1998; 22 (2) :416-21.
Sturmhofel, S. H. Swartzwelder, H. S. Alcohol’s Effects on the Adolescent Brain. Alcohol Research & Health, 2004;28 (4):213-21.
Roberto, M., Nelson, T. E., Ur, C. L and Gruol, D. L. Long-Term Potentiation in The Rat Hippocampus is Reversibly Depressed by Chronic Intermittent ethanol exposure. J. Neurophysiol,2001;87:2385-97.
Franke,H.,Kittner,H.,Berger,P.,Wirkner, K. And Schramek, J. The Reaction of Astrocytes and Neurons in
The Hippocampus of Adult Rats During Chronic Ethanol Treatment and Correlations to behavioral Impairments. Alcohol,1997; 14(5): 445-54
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