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Evaluation of the Antifertility Effect and Toxicity of Areca Catechu as Oral Contraceptive: Study on Male Rats

Authors

DOI:

https://doi.org/10.21776/ub.jkb.2022.032.01.3

Keywords:

areca, fertility, antifertility, hepatotoxic, nephrotoxic

Abstract

Currently, very few male contraceptive methods are available. Areca nuts are known to have an antifertility effect, but the effective, safe dose is not certainly known. Data on its effectiveness and safety are needed to develop the potential of the areca nuts as an herbal contraceptive in men. This study determines the antifertility effect of areca nut administration at doses of 40, 30, and 20 mg/kgBW and their safety on the kidneys and liver. The green-colored raw areca nuts were used. The treatment groups were male rats whose fertility status was known before treatment. The treatment groups were given betel nut powder dissolved with distilled water using a sonde, while the control group was just given distilled water. After 28 days of treatment, male rats were bred again. Hematoxylin-eosin staining was used in histopathological examination.  Morphology, motility, and the number of spermatozoa were also counted. The administration of areca nuts caused a decreasing number of litters, but only the group given 40 mg/kgBW dose had a significant decrease (p<0.05).  There were a damaged testes, a decreasing number and motility of spermatozoa as well as increasing spermatozoa abnormalities. There were no changes in liver tissue, but there was a mild grade cast in kidney tissue. Areca nut dose of 40 mg/kgBW decreases fertility in male rats and causes a mild tubular cast in kidney tissue.

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Author Biographies

Ave Olivia Rahman, University of Jambi

pharmacology

Hasna Dewi, University of Jambi

histology and Anatomy pathologist

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Published

2022-03-02

Versions

Issue

Vol. 32 No. 1 (2022)

Section

Research Article

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