PREDIKTOR ASMA PADA USIA 7 TAHUN SETELAH MENDERITA BRONKIOLITIS AKUT KARENA RESPIRATORY SYNCYTIAL VIRUS: SUATU STUDI PROSPEKTIF
DOI:
https://doi.org/10.21776/ub.jkb.2006.022.03.7Abstract
Infants are at increased risk of developing asthma  after RSV (Respiratory Syncytial Virus) acute bronchiolitis. The hypothesis that cytokine production is related to the development of asthma after RSV bronchiolitis. The diagnosis of RSV bronchiolitis was verified using the Abbott test pack RSV, a rapid enzyme immuno assay for direct detection of viral antigen in nasopharyngeal secretion. Changes in FEV1 (Forced Expiratory Volume in 1 second) were determined using spirometri, IL-4 and IFN-γlevels were determined using the enzyme-linked immunosorbant assay (ELISA) method. In this study, 62 children hospitalized for RSV bronchiolitis were followed prospectively, 55 (88.7%) childrencompleted the study and 41 children (74.5%) had asthma at 7 years of age. RSV bronchiolitis children were more frequent among boys (boy /girl ratio: 2). Episodes of wheezing more than 8 had specifity and sensitivity of 100% respectivelly,might be the very useful predictor for asthma. The cut off level over 40.84 pg/ml for IL-4, below 14.12 pg/ml for IFN-γ, IL-4 / IFN-γratio over 3 and episodes of wheezing over 8 may be used to predict asthma after RCV bronchiolitis.Downloads
References
Fjaerli HO, Farstad T, Rod G, et al. Acute bronchiolitis in infancy as risk factor for wheezing and reduced pulmonary function by seven years in Akershus County. Norway: BMC Pediatri ;2005;.5:31.
Stein RT, Sherril D, Morgan WJ, et al. Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years. Lancet 1999;354:541.
Martinez FD. Respiratory syncytial virus bronchiolitis and the pathogenesis of childhood asthma. Pediatr Infect Dis J 2003; 22: 576.
Lemanske RF. Does respiratory syncytial viral–induced bronchiolitis result from helper T cell type 1 / type 2 cytokine imbalance?Am J Respir Crit Care Med 2003;168:625–627.
Sigurs N, Bjarnason R, Sigurbergsson F, et al. Asthma and immunoglobulin E antibodies: a prospective cohort study with matched controls. Pediatrics 1995; 95: 500–506.
Pullan C, Hey E. Wheezing, asthma, and pulmonary disfunction 10 years after infection with respiratory syncytial virus in infancy.Br Med J 1982;5:1665–1669.
UKK Respirologi PP IDAI.. Konsensus Nasional Asma Anak.2005
Ying S, Hambert M, Barkans J, et al. Expression of IL-4 and IL-5 mRNA and protein product by CD4+and CD8+ T cells, eosinophils, and mast cells in bronchial biopsies obtained from atopic and non atopic (intrinsic) asthmatics. Immunol 1997;158:3539–3544.
Renzi PM, Turgeon JP, Marcotte JE, et al. Reduced interferon-γproduction infants with bronchiolitis and asthma. Am J Respir Crit Care Med 1999;159:1417–1422.
Legg JP, Hussain IR, Warner JA, et al. Type 1 and type 2 cytokine imbalance in acute respiratory syncytial virus bronchiolitis. Am J Respir Crit Care Med 2003;168:633–639.
Renzi PM, Turgeon JP, Yang JP, et al. Cellullar immunity is activated and a Th2 response is associated with early wheezing in infants after bronchiolitis. J Pediatr 1997;130:584–594.
Lebman DA, Coffman RL. Interleukin-4 causes isotype switching to IgE in T cell-stimulated clonal B cell cultures.J Exp Med 1988;168:853–862.
Pene J, Rousset F, Briere F, et al. IgE production by normal human B cells induced by alloreactive T cells clones is mediated by IL-4 and suppressed by IFN-gamma.J Immunol 1988;141:1218–1224.
Scott P. IFN-gamma modulates the early development of Th1 and Th2 responses in a murine model of cutaneous leishmaniasis.J Immunol 1991;147:3149–3155.
Maggi E, Paronchi P, Manetti R, et al. Reciprocal regulatory effects of IFN-gamma and IL-4 on the in vitro development of human Th1 and Th2 clones. J Immunol 1992;148:2142–2147.
Stein RT, Sherril D, Morgan WJ, et al. Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years.Lancet 1999;354:541–545.
Sigurs N, Bjarnason R, Sigurbergsson F, et al. Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at age 7. Am J Respir Crit Care Made 2000;161:1501–1507.
Downloads
Published
Issue
Section
License
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).