PERBEDAAN POLA RESISTENSI Staphylococcus koagulase negatifISOLAT DARAH TERHADAP ANTIBIOTIKA DI RSU Dr SAIFUL ANWAR MALANG TAHUN 2000-2001 DENGAN 2004-2005

Authors

  • Sjoekoer M. Dzen Laboratorium Mikrobiologi Fakultas Kedokteran Universitas Brawijaya / RSU dr .Saiful Anwar Malang
  • Sanarto Santoso Laboratorium Mikrobiologi Fakultas Kedokteran Universitas Brawijaya / RSU dr .Saiful Anwar Malang
  • Roekistiningsih Roekistiningsih Laboratorium Mikrobiologi Fakultas Kedokteran Universitas Brawijaya / RSU dr .Saiful Anwar Malang
  • Dewi Santosaningsih Laboratorium Mikrobiologi Fakultas Kedokteran Universitas Brawijaya / RSU dr .Saiful Anwar Malang

DOI:

https://doi.org/10.21776/ub.jkb.2005.021.03.4

Abstract

Coagulase negative staphylococci (CoNS) are the common bacterias causing hospital-acquired infection manifested as bacteremia. The antibiotics therapy against bacterial infection is mostly empiric, whereas the bacterial pattern and its sensitivity to antibiotics differ between region and from year to year. The objective of this study wasto determine the changes of prevalence and antibiotics sensitivity pattern of CoNS, the etiologic agent of bacteremia in patients hospitalised in Dr.Saiful Anwar General Hospital, Malang. Culture and antibiotic sensitivity test wereperformed on 650 and 1063 blood samples during the year of 2000-2001and 2004-2005 respectively in the Laboratory of Microbiology, Faculty of Medicine, Brawijaya University / Dr.Saiful Anwar General Hospital in Malang following NCCLS  1997. ChiSquare test was used to analysed of data. The result of this study revealed that the CoNS was the most isolate found in the blood samples and its resistance to beta lactam antibiotics tends to increase statistically. Key words:Coagulase negative staphylococci, antibiotics sensitivity pattern

Downloads

Download data is not yet available.

References

DAFTAR KEPUSTAKAAN

Giusti MD, Pacifico L, Tufi D, Panero A, Boccia A, and Chiesa C. Phenotypic Detection of Nosocomial mecA-positive

Coagulase Negative Staphylococci from Neonates. Journal of Antimicrobial Chemotherapy 1999;44: 351-358

Graham JC, Murphy OM, Stewart D, Kearns AM, Galloway A, and Freeman R. Comparison of PCR Detection of mecA with Methicillin and Oxacillin Disc Susceptibility Testing in Coagulase-Negative Staphylococci. Journal of Antimicrobial

Chemotherapy 2000; 45: 111-113.

Burnie JP, Naderi-Nasab M, Loudon KW, and Matthews RC. An Epidemiological Study of Blood Culture Isolates of Coagulase-Negative Staphylococci Demonstrating Hospital-Acquired Infection. J.Clin.Microbiol 1997; 35(7): 1746-1750

Baron EJ, Peterson LR, Finegold SM. Methods for Testing Antimicrobial Effectiveness. Bailey & Scott’s Diagnostic

Microbiology 9th ed.Missouri: Mosby; 1994; 168-188.

Mahoudeau I, Delabranche X, Prevost G, Mointeil H, and Piemont Y. Frequency of Isolation of Staphylococcus Intermedius from Humans. J.Clin.Microbiol 1997; 35(8): 2153-2154.

Tenover FC, Jones RN, Swenson JM, Zimmer B, McAllisterS, and Jorgensen JH. Method for Improved Detection of Oxacillin Resistance in Coagulation-Negative Staphylococci: Results of a Multicenter Study. J.Clin Microbiol 1999;37(12): 4051-4058.

Kawamura Y, Hou X-G, Sultana F, Hirose G, Miyake M, Shu S-E, and Ezaki T. Distribution of Staphylococcus Species

among Human Clinical Specimens and Emended Description of Staphylococcus caprae. J.Clin.Microbiol 1998;36(7):2038-2042.

Horstkotte MA, Knobloch JK-M, Rohde H, Dobinsky S, and Mack D. Rapid Detection of Methicillin Resistance in Coagulation-Negative Staphylococci with the VITEK2 System. J.Clin.Microbiol 2002; 40(9): 3291-3295.

Lilik Zuhriyah. Gambaran Bakteriologis Tangan Perawat (Bacteriological Descriptions of Nurses’s Hand).Jurnal

Kedokteran Brawijaya 2004; XX (1): 53-56.

Pfaller MA, Jones RN, Doem GV, Kugler K, and Group SP. Bacterial Pathogens Isolated from Patients with Bloodstream Infections Frequencies of Occurrence andAntimicrobial Surveillance Program (United States and Canada). Antimicrobial Agents and Chemotherapy 1998; 42(7):1762-1770.

Cuevas O, Cercenado E, Vindel A, Guinea J, Sanchez-Conde M, Sanches Somolinus M, Bouza E, and Spanish group for the study of Staphylococcus. Evolution of the Antimicrobial Resistance of Staphylococcus spp. In Spain: Five Nationwide Prevalence Studies, 1986 to 2002. J.Antimicrobial Agents and Chemotherapy 2004; 48(11): 4240-4245.

Downloads

Published

2013-04-16

Issue

Section

Original Article

Most read articles by the same author(s)