PERBEDAAN POLA RESISTENSI Staphylococcus koagulase negatifISOLAT DARAH TERHADAP ANTIBIOTIKA DI RSU Dr SAIFUL ANWAR MALANG TAHUN 2000-2001 DENGAN 2004-2005
DOI:
https://doi.org/10.21776/ub.jkb.2005.021.03.4Abstract
Coagulase negative staphylococci (CoNS) are the common bacterias causing hospital-acquired infection manifested as bacteremia. The antibiotics therapy against bacterial infection is mostly empiric, whereas the bacterial pattern and its sensitivity to antibiotics differ between region and from year to year. The objective of this study wasto determine the changes of prevalence and antibiotics sensitivity pattern of CoNS, the etiologic agent of bacteremia in patients hospitalised in Dr.Saiful Anwar General Hospital, Malang. Culture and antibiotic sensitivity test wereperformed on 650 and 1063 blood samples during the year of 2000-2001and 2004-2005 respectively in the Laboratory of Microbiology, Faculty of Medicine, Brawijaya University / Dr.Saiful Anwar General Hospital in Malang following NCCLS  1997. ChiSquare test was used to analysed of data. The result of this study revealed that the CoNS was the most isolate found in the blood samples and its resistance to beta lactam antibiotics tends to increase statistically. Key words:Coagulase negative staphylococci, antibiotics sensitivity patternDownloads
References
DAFTAR KEPUSTAKAAN
Giusti MD, Pacifico L, Tufi D, Panero A, Boccia A, and Chiesa C. Phenotypic Detection of Nosocomial mecA-positive
Coagulase Negative Staphylococci from Neonates. Journal of Antimicrobial Chemotherapy 1999;44: 351-358
Graham JC, Murphy OM, Stewart D, Kearns AM, Galloway A, and Freeman R. Comparison of PCR Detection of mecA with Methicillin and Oxacillin Disc Susceptibility Testing in Coagulase-Negative Staphylococci. Journal of Antimicrobial
Chemotherapy 2000; 45: 111-113.
Burnie JP, Naderi-Nasab M, Loudon KW, and Matthews RC. An Epidemiological Study of Blood Culture Isolates of Coagulase-Negative Staphylococci Demonstrating Hospital-Acquired Infection. J.Clin.Microbiol 1997; 35(7): 1746-1750
Baron EJ, Peterson LR, Finegold SM. Methods for Testing Antimicrobial Effectiveness. Bailey & Scott’s Diagnostic
Microbiology 9th ed.Missouri: Mosby; 1994; 168-188.
Mahoudeau I, Delabranche X, Prevost G, Mointeil H, and Piemont Y. Frequency of Isolation of Staphylococcus Intermedius from Humans. J.Clin.Microbiol 1997; 35(8): 2153-2154.
Tenover FC, Jones RN, Swenson JM, Zimmer B, McAllisterS, and Jorgensen JH. Method for Improved Detection of Oxacillin Resistance in Coagulation-Negative Staphylococci: Results of a Multicenter Study. J.Clin Microbiol 1999;37(12): 4051-4058.
Kawamura Y, Hou X-G, Sultana F, Hirose G, Miyake M, Shu S-E, and Ezaki T. Distribution of Staphylococcus Species
among Human Clinical Specimens and Emended Description of Staphylococcus caprae. J.Clin.Microbiol 1998;36(7):2038-2042.
Horstkotte MA, Knobloch JK-M, Rohde H, Dobinsky S, and Mack D. Rapid Detection of Methicillin Resistance in Coagulation-Negative Staphylococci with the VITEK2 System. J.Clin.Microbiol 2002; 40(9): 3291-3295.
Lilik Zuhriyah. Gambaran Bakteriologis Tangan Perawat (Bacteriological Descriptions of Nurses’s Hand).Jurnal
Kedokteran Brawijaya 2004; XX (1): 53-56.
Pfaller MA, Jones RN, Doem GV, Kugler K, and Group SP. Bacterial Pathogens Isolated from Patients with Bloodstream Infections Frequencies of Occurrence andAntimicrobial Surveillance Program (United States and Canada). Antimicrobial Agents and Chemotherapy 1998; 42(7):1762-1770.
Cuevas O, Cercenado E, Vindel A, Guinea J, Sanchez-Conde M, Sanches Somolinus M, Bouza E, and Spanish group for the study of Staphylococcus. Evolution of the Antimicrobial Resistance of Staphylococcus spp. In Spain: Five Nationwide Prevalence Studies, 1986 to 2002. J.Antimicrobial Agents and Chemotherapy 2004; 48(11): 4240-4245.
Downloads
Published
Issue
Section
License
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).