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Analog Rice Reduces Weight and Total Cholesterol Levels in Overweight and Hypercholesterolemic Rats

Septiarina Putri Dewantari, Hairrudin Hairrudin, Elly Nurus Sakinah
  Jurnal Kedokteran Brawijaya, Vol 31, No 1 (2020),  pp.7-12  

Abstract


Overweight, whose prevalence is increasing, is caused by unbalanced consumption patterns such as high consumption of fat and can trigger hypercholesterolemia. Analog rice (AR), which has better nutritional content than ordinary rice, is thought to have beneficial effects on health. This study aimed to determine the potential of analog rice in reducing body weight and total cholesterol levels. A total of 24 male Wistar rats were divided into four groups, namely: I) control, II) ordinary rice treatment, III) analog rice 1 treatment (PBA1) and IV) analog rice 2 treatment (PBA2). The control group was given standard feed for 40 days ad libitum. Groups II, III, and IV were given a combination induction of high-fat diet (HFD) for 40 days ad libitum and intraperitoneal injection of streptozotocin (STZ) 35 mg/kg single dose on day 33. All groups were then given the treatment of diet for three weeks according to their respective groups, namely the standard, ordinary rice, analog rice 1, and analog rice 2 feed. Body weight and total cholesterol levels were measured in the pre-induction, post-induction/pre-treatment (pre-test), and post-treatment (post-test). The results of the study showed that the induction of the HFD-STZ combination carried out resulted in a significant increase in body weight and total cholesterol levels. Measurements made after dietary therapy showed that body weight and total cholesterol levels in the I and II groups did not change significantly, whereas those in the III and IV groups decreased significantly (p<0.05). This study concluded that the administration of analog rice could reduce body weight and total cholesterol levels in overweight and hypercholesterolemia rats. 


Keywords


Analog rice; high-fat diet; hypercholesterolemia; overweight; streptozotocin

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References


World Health Organization. Obesity and Overweight. (Online) 2018. https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight. [diakses 23 Januari 2019].

Fairudz A and Nisa K. Pengaruh Serat Pangan terhadap Kadar Kolesterol Penderita Overweight. Majority. 2015; 4(8): 121-126.

Septiana P, Nugroho FA, and Wilujeng CS. Konsumsi Junk Food dan Serat Pada Remaja Putri Overweight dan Obesitas Yang Indekos. Jurnal Kedokteran Brawijaya. 2018; 30(1): 61-67.

Badan Penelitian dan Pengembangan Kesehatan Kementerian Kesehatan Republik Indonesia. Riset Kesehatan Dasar. Jakarta: Departement Kesehatan RI; 2013.

Budijanto S and Yuliyanti. Study of Preparation Sorghum Flour and Application for Analogues Rice Production. Jurnal Teknologi Pertanian. 2012; 13(3): 177-186.

Yuwono SS and Zulfiah AA. Formulasi Beras Analog Berbasis Tepung Mocaf dan Maizena dengan Penambahan CMC dan Tepung Ampas Tahu. Jurnal Pangan dan Argoindustri. 2015;3(4):1465-1472.

Subagio A, Witono Y, Hermanuadi D, Nafi A, and Windrati WS. Pengembangan “Beras Cerdas” Sebagai Pangan Pokok Alternatif Berbahan Baku Mocaf. Prosiding InSINas. Jember, November 29-30, 2012: 157-160.

Hairrudin, Soetjipto, and Handajani R. Hypoglycemic Effect of High-Resistant Starch Analog Rice Through GLP-1 and Insulin or High-Resistant Starch Analog Rice Attenuates Blood Glucose Level Through Enhancement of GLP-1 and Insulin. Asian Journal Pharmaceutical and Clinical Reserch. 2019; 12(8): 172-175

Noviasari S , Kusnandar F, Setiyono A, and Budijanto S. Beras Analog sebagai Pangan Fungsional dengan Indeks Glikemik Rendah. Jurnal Gizi Pangan. 2015; 10(3): 225-232.

Zaman SA and Sarbini SR. The Potential of Resistant Starch as a Prebiotic. Critical Reviews in Biotechnology. 2016; 36(3): 578-584.

Gentile CL, Ward E, Holst JJ, et al. Resistant Starch and Protein Intake Enhances Fat Oxidation and Feelings of Fullness in Lean and Overweight/Obese Women. Nutrition Journal. 2015; 14(113): 1-10.

Kharisma T. Studi Hipokolesterolemik Beras Analog Secara In Vivo pada Tikus Sprague Dawley (SD). [Tesis]. Institut Pertanian Bogor, Bogor. 2015.

Hariyanto B, Cahyana PT, Putranto AT, Wahyuningsih SB, and Marsono Y. Penggunaan Beras Sagu Untuk Penderita Pradiabetes. Jurnal Pangan. 2017; 26(2): 1-10.

Srinivasan K, Viswanad B, Asrat L, Kaul CL, and Ramarao P. Combination of High-Fat Diet-Fed and Low-Dose Streptozotocin-Treated Rat: A Model for Type 2 Diabetes and Pharmacological Screening. Pharmacological Research. 2005; 52(4): 313-320.

Arumugam S and Natesan S. Hypoglycemic Effects Of Barleria Noctiflora Fractions On High Fat Fed With Low Dose Streptozotocin Induced Type-2 Diabetes In Rats. International Journal of Pharmacy and Pharmaceutical Sciences. 2016; 8(2): 193-200.

Lu Y, Liu Y, Li H, Wang X, Wu W, and Gao L. Effect and Mechanisms of Zinc Supplementation in Protecting Against Diabetic Cardiomyopathy in a Rat Model of Type 2 Diabetes. Bosnian Journal of Basic Medical Sciences. 2015; 15(1): 14-20.

Marques C, Meireles M, Norberto S, et al. High-fat Diet-induced Obesity Rat model: a comparison between Wistar and Sprague-Dawley Rat. Adipocyte. 2016; 5(1): 11-21.

Rodwell VW, Bender DA, Botham KM, Kennelly PJ, and Weil PA. Harper’s Illustrated Biochemistry. 30th ed, New York: McGraw-Hill Education; 2015; 168-185, 223-226.

Harsa IMS. Efek Pemberian Diet Tinggi Lemak terhadap Profil Lemak Darah Tikus Putih (Rattus norvegicus). Jurnal "Ilmiah Kedokteran". 2014; 3(1): 21-28.

Wiardani NK, Sugiani PPS, and Gumala NMY. Konsumsi Lemak Total, Lemak Jenuh, dan Kolesterol sebagai Faktor Resiko Sindroma Metabolik pada Masyarakat Perkotaan di Denpasar. Jurnal Gizi Klinik Indonesia. 2011; 7(3): 107-114.

Sunarsi S, Sugeng M, Wahyuni S, and Ratnaningsih W. Memanfaatkan Singkong Menjadi Tepung Mocaf Untuk Pemberdayaan Masyarakat Sumberejo. Sukoharjo; LPPM Univet Bantara Sukoharjo; 2011.

Lopulalan CGC, Mailoa M, and Pelu H. Analisa Sifat Kimia dan Fisik Modified Cassava Flour (Mocaf) (Varietas Lokal Sangkola) Asal Desa Waai, Maluku Tengah. AGRITEKNO: Jurnal Teknologi Pertanian. 2018; 5(1): 7-12.

Suarni and Yasin M. Jagung sebagai Sumber Pangan Fungsional. Iptek Tanaman Pangan. 2011; 6(1): 41-56.

Salleh SN, Fairus AAH, Zahary M, Bhaskar Raj N, and Mhd Jalil AM. Unravelling The Effects of Soluble Dietary Fibre Supplementation on Energy Intake and Perceived Satiety in Healthy Adults: Evidence from Systematic Review and Meta-Analysis of Randomised-Controlled Trials. Foods. 2019; 8(1): 15.

Bozzetto L, Costabile G, Della Pepa G, et al. Dietary Fibre as a Unifying Remedy for the Whole Spectrum of Obesity-Associated Cardiovascular Risk. Nutrients. 2018; 10(7): 943-975.

Adam CL, Thomson LM, Williams PA, and Ross AW. Soluble Fermentable Dietary Fibre (Pectin) Decreases Caloric Intake, Adiposity and Lipidaemia in High-Fat Diet-Induced Obese Rats. PLoS ONE. 2015; 10(10): 1-14.

Firdaus J, Sulistyaningsih E, Subagio A. Resistant Starch Modified Cassava Flour (MOCAF) Improves Insulin Resistance. Asian Journal of Clinical Nutrition. 2018; 10(1): 32-36.




DOI: http://dx.doi.org/10.21776/ub.jkb.2020.031.01.2

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