• Yully Endang Hernani Laboratorium Skill Fakultas Kedokteran Universitas Brawijaya



Adiponectin  is  a  adipocyte  derivate  protein  involves  in  sensitivity  of  insulin,  anti-inflamation,  and  anti-
atherogenic  found  largely  in  plasma.  The  decrease  of  adiponectin  in  the  plasma  is  related  to  obesity,
cardiovascular diseases, type II diabetes, hypertension and vascular injuries in nice. In vivo research on strain
balb/c mice showed that excessive Adiponectin expression inhibits atherosclerosis with Apo E deficiency. The
aim  of  this  research  is  to  find  protective  mechanisms  of  adiponectin  on  vascular  utilizing  in-vitro  Infected
HUVEC’s  culture.  There  were  5  groups  :(A)  control  negative  group  or  normal  HUVEC’s,


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Goldstein, B.J., and Scalia, R. Adiponectin: a novel adipokine linking adipocytes and vascular function. J. Clin.Endocrinol.Metab. 2004;89:2563–2568.

Scherer,P.E.Adipose tissue: from lipid storage compartment to endocrine organ.Diabetes. 2006;55:1537–

Arita, Y., Kihara, S., Ouchi, N, et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem. Biophys. Res. Commun. 1999;257:79–83.

Hotta, K., Funahashi, T., Arita, Y, et al. Plasma concentrations of a novel, adipose-specific protein, adiponectin,in type 2 diabetic patients. Arterioscler. Thromb.Vasc. Biol. 2000;20:1595–1599.

Iwashima, Y., Katsuya, T., Ishikawa, K, et al. Hypoadiponectinemia is an independent risk factor for hypertension. Hypertension. 2004;43:1318–1323.

Ouchi, N., Terauchi, Y., Yamauchi, T, et al. Adiponectin, an adipocytederived plasma protein, inhibits endothelial NFkappaB signaling through a cAMP dependent pathway. Circulation. 2000;102:1296–1301.

Kubota, N. Disruption of adiponectin causes insulin resistance and neointimal formation. J. Biol. Chem. 2002;277:25863–25866.

Matsuda,M.,Shimomura L., Sata, M, et al.Role of adiponectin in preventing vascular stenosis. The missing

link of adipo-vascular axis. J. Biol. Chem.2002;277:37487–37491.

Lefer, A.M.,and Scalia, R. Nitric oxide in inflammation. In Physiology of inflammation. K. Ley, editor. Oxford University Press. New York, New York, USA. 2001;447–472.

De Caterina, R., Libby, P., Peng, HB, et al. Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines.J. Clin.Invest.1995;96:60–68.

Chen, H.,Montagnani,M.,Funahashi,T.,Shimomura,I.,and Quon, M.J. Adiponectin stimulates production of nitric oxide in vascular endothelial cells. J. Biol. Chem. 2003;278:45021–45026.

Motoshima,H.,Wu,X.,Mahadev, K., and Goldstein, B.J. Adiponectin suppresses proliferation and superoxide generation and enhances eNOS activity in endothelial cells treated with oxidized LDL. Biochem. Biophys. Res. Commun. 2004;315:264–271.

Ouedraogo,R.,Wu,X.,Xu,S,et al. Adiponectin suppression of high-glucose-induced reactive oxygen species in vascular endothelial cells: evidence for involvement of a cAMP signaling pathway. Diabetes.2006; 55:1840–1846.

Valerio, A.,Cardile, A., Cozzi V., et al. TNF-αdownregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents. J. Clin. Invest. 2006; 116:2791–2798. doi:10.1172/JCI28570.

Neumann,P., Gertzberg, N., and Johnson, A. TNF-alpha induces a decrease in eNOS promoter activity. Am. J. Physiol. Lung Cell. Mol. Physiol. 2004;286:L452–L459.

Arita,Y.,Kihara, S., Ouchi, N, et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem. Biophys. Res. Commun. 1999;257:79–83.

Shimabukuro, M., Higa, N., Asahi T, et al. Hypoadiponectinemia is closely linked to endothelial dysfunction in man. J. Clin. Endocrinol. Metab. 2003;88:3236–3240.

Okamoto,Y., Kihara, S., Ouchi, N, et al. Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice. Circulation.2002;106:2767–2770.

Nakashima,Y.,Raines, E.W., Plump, A.S., Breslow, J.L., and Ross, R. Upregulation of VCAM-1 and ICAM-1 at atherosclerosis-prone sites on the endothelium in the ApoE-deficient mouse. Arterioscler. Thromb. Vasc. Biol. 1998;18:842–851.

Collins, T., Read, MA., Neish, AS., Whitley, MZ., Thanos, D and Maniatis, T. Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers. FASEB J. 1998;9:899–






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