Pemberian Jus Tomat (Lycopersicum esculentum) Per Oral Dapat Menurunkan Jumlah Sel Epitel Bronkhus Utama Tikus Putih yang Dipapar Asap Rokok Sub Kronik
DOI:
https://doi.org/10.21776/ub.jkb.2010.026.01.12Abstract
ABSTRAKAsap rokok mengandung radikal bebas yang dapat dipercaya dapat meningkatkan sel epitel bronkhus. Tujuan Penelitian ini dilakukan untuk mengidentifikasi efek jus tomat yang mengandung likopen dalam menurunkan sel epitel bronkhus akibat stres oksidatif  yang di sebabkan paparan asap subkronik pada tikus. Penelitian dilakukan dengan desain eksperimental pada 20 tikus jantan usia 2-3 bulan dengan berat badan 150-200 gram dan di kelompokkan dalam  kelompok kontrol positif dan negatif juga tiga kelompok perlakuan dengan pemberian jus tomat 1.15 ml/hari, 2.3 ml/hari, dan 4.6 ml/hari. Uji One-Way ANOVA dan Post hoc LSD menunjukkan bahwa peningkatan intake jus tomat menurunkan  jumlah sel epitel bronkus secara signifikan hingga sama dengan kondisi normal.Kata Kunci : Jus tomat, likopen, paparan asap rokok sub kronis, sel epitel bronkus.Downloads
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Published
2013-03-15
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