Respon Imun terhadap Vaksin Influenza pada Remaja

Authors

  • Meita Dhamayanti Departemen Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Padjadjaran/Rumah Sakit Dr. Hasan Sadikin Bandung
  • Kusnandi Rusmil Departemen Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Padjadjaran/Rumah Sakit Dr. Hasan Sadikin Bandung
  • Ponpon Idjradinata Departemen Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Padjadjaran/Rumah Sakit Dr. Hasan Sadikin Bandung

DOI:

https://doi.org/10.21776/ub.jkb.2012.027.02.9

Abstract

Influenza merupakan penyakit yang mudah menular dengan mortalitas dan morbiditas tinggi serta sering menimbulkan kejadian  luar biasa, epidemi, dan pandemi. Pada anak  sekolah,  influenza menyebabkan  tingginya angka absensi dan remaja merupakan  sumber  penularan  terbesar .  Penelitian  dilakukan  untuk menilai  respons  imun    terhadap  vaksin influenza pada kelompok remaja 12–18 tahunpada bulan Juni–September 2008, di Puskesmas Garuda Bandung. Desain dilakukan dengan  intervensional,  longitudinal, acak sederhana, dan tersamar tunggal. Vaksin  influenza yang mengandung 3 jenis virus A/H1N1, A/H3N2 dan B, disuntikkan intramuskular. Pengambilan darah dilakukan pra dan pasca vaksinasi. Pemeriksaan kadar antibodi dilakukan dengan metode hemaglutinasi inhibisi (HI). Respons imun dinilai berdasarkan nilai serokonversi, dan peningkatan geometric mean titer (GMT). Subjek dibagi 2 kelompok, 69 (52,7%) remaja pertengahan (12–15  tahun) dan 62  (47,3%)  remaja akhir  (16–18  tahun). Semua  subjek  telah mempunyai kadar antibodi protektif HI>1:40 pascavaksinasi. Nilai serokonversi kedua kelompok berbeda bermakna pada pra  (p=0,02) dan pascavaksinasi (p=0,02). Serokonversi  terhadap virus A/H3N2 antara remaja pertengahan dan akhir berbeda bermakna pada pravaksinasi (p=0,02). Pada pra dan pascavaksinasi  terdapat peningkatan GMT bermakna  terhadap ketiga  jenis virus  influenza  (Zw 9,73; 9,19; 9,59 dan p=0,00). Simpulan, vaksinasi influenza pada remaja menghasilkan kadar protektif. Respons imun remaja pertengahan dan akhir  tidak berbeda, namun  remaja pertengahan  tampak   lebih  responsif.

Kata Kunci: Influenza,  remaja,  responsimun, vaksin

Downloads

Download data is not yet available.

References

Centers for Disease Control and Prevention. Update: Influenza Activity-United States, September 28, 2008–April 4, 2009, and Composition of the 2009-10 Influenza Vaccine. Morbidity and Mortality Weekly Report. 2009; 58(14): 369–374.

Mari K and Blum R. International Adolescent Health. In: Fisher M (Ed). Textbook of Adolescent Health Care edisi 1. New York: American Academy of Pediatrics; 2011; p. 17–21.

Jaspan HE, Lawn SD, Safrit JT, and Bekker L. The Maturing Immune System: Impl ications for Development and Testing H1N1 Vaccines for Children and Adolescents. AIDS. 2006; 20(4): 483–494.

Radzik M, Sherer S, and Neinstein L. Psychosocial Development in Normal Adolescents. In: Neinstein LS (Ed). Adolescent Health Care 5th edition. Philadelphia: Lippincott WIlliams and Wilkin; 2008; p. 27-31.

Chng WJ, Tan GB, and Kuperan P. Establishment of Adult Peripheral Blood Lymphocyte Subset Reference Range For an Asian Population by Single-Platform Flow Cytometry: Influence of Age, Sex, and Race and Comparison with Other Published Studies. Clinical and Diagnostic Laboratory Immunology. 2004; 11(1): 168–173.

Davis MM, King JC, Moag L, Cummings G, and Magder LS. Count ywide S chool -Bas ed Inf luenza Immunization: Direct and Indirect Impact on Student Absenteeism. Pediatrics. 2008; 122(1): e260–265.

Kim TH, Johnstone J, and Loeb M. Vaccine Herd Effect. Scandinavian Journal of Infectious Disease. 2011; 3(9): 683–689.

Charu V, Viboud C, Simonsen L, et al. Influenza-Related Mortality Trends in Japanese and American Seniors: Evidence for the Indirect Mortality Benefit of Vaccinating Schoolchildren. Plos One. 2011; 6(11): e26282.

Fiore AE, Uyeki TM, Broder K, et al. Prevention and Control of Influenza with Vaccines Recommendations of the Advisory Committee on Immunization Practices (ACIP). Morbidity and Mortality Weekly Report. 2010; 59(8): 1-62.

Wright P, Neumann G, and Kawaoka Y. Orthomyxoviruses. In: Knipe D (Ed). Fields Virology 5th edition. Philadelphia: Lippincott William & Wilkins; 2007; p. 1691–1727.

Ikatan Dokter Anak Indonesia. Jadwal Imunisasi Untuk A n a k d a n R e m a j a 2 0 0 8 . ( O n l i n e). http://www.idai.or.id/remaja/artikel.asp?q=201176101020

Murphy K, Travers P, and Walport M. Antigen Recognition by B-Cell and T-Cell Receptors. In: Taylor & Francis. Janeway's Immunobiology 7th edition. New York: Garland Science; 2008; p. 111–142.

Bridges CB, Katz JM, Levandowski R, and Cox NJ. Inactivated Influenza Vaccines. In: Plotkin SA (Ed). Vaccines 5th edition. Philadelphia: WB Saunders; 2008; p. 259–290.

Barr IG, McCauley J, Cox N, et al. Epidemiological, Antigenic and Genetic Characteristics of Seasonal Influenza A(H1n1), A(H3n2) and B Influenza Viruses: Basis for the WHO Recommendation on the

Composition of Influenza Vaccines for Use in the 2009–2010 Northern Hemisphere Season. Vaccine. 2010; 28(5): 1156–1167.

Taunbenberger JK. The Originan d Virulence of the

'Spanish" Influenza Virus. Proceedings of the American Philosophical Society. 2006; 150(1): 86-112.

Haaheim LR. Basic Influenza Virology and Immunology. In: Van-Tam J (Ed). Introduction to Pandemic Influenza 1st edition. Cambridge: Cambridge University Press; 2010; p. 14–26.

Englund JA, Walter EB, Fairchok MP, Monto AS, and Neuzil KM. A Comparison of 2 Influenza Vaccine Schedules in 6-to 23-Month-Old Children. Pediatrics. 2005; 115(4): 1039–1047.

Food and Drug Administration. Guidance for Industry, Toxicity Grading Scale For Healthy Adult and dolescent Volunteers Enrolled in Preventive Vaccine Trial .(Online) 2005. http://www.fda.gov/ BiologicsBloodVaccines/GuidanceComplianceRegulatoryInformation/Guidances/Vaccines/ucm074775.htm

Downloads

Published

2013-03-04

Issue

Vol. 27 No. 2 (2012)

Section

Research Article

License

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).