Kadar Heat Shock Protein 70 pada Persalinan Prematur
DOI:
https://doi.org/10.21776/ub.jkb.2015.028.04.9Abstract
Persalinan preterm merupakan masalah kesehatan bagi negara maju maupun berkembang, berperan besar peningkatan morbiditas dan mortalitas neonatus, serta sering berdampak kesehatan jangka panjang seperti celebral palsy, kebutaan, dan perkembangan psikomotorik. Menganalisis apakah terdapat perbedaan serta hubungan antara kadar HSP70 persalinan preterm dibandingkan kehamilan normal. Observasional analitik dengan rancangan potong lintang. Jumlah subyek penelitian 60 ibu hamil dibagi dua kelompok, persalinan preterm 30 ibu hamil dan kelompok kehamilan normal 30 ibu hamil. Pemeriksaan HSP70 dilakukan di laboratorium klinik Prodia. Analisa statistik dengan uji Chi-kuadrat. Berdasarkan karakteristik ibu pada kedua kelompok penelitian, pendidikan dan LILA (Lingkar Lengan Atas) berpengaruh terhadap kejadian persalinan preterm (Probability (p)=0,008 dan p=0,002). Ibu berpendidikan SD mengalami persalinan preterm sebanyak 6,6 kali lebih besar (Prevalence Ratio (PR)=6,682 dan p=0,029), sedangkan berpendidikan SMP berisiko mengalami persalinan preterm sebanyak 3 kali lebih besar (PR=3,27 dan p=0,054) dibanding SMA. Ibu berLILA kurang memiliki risiko persalinan preterm sebanyak 5,5 kali lebih besar dibanding ibu berLILA normal (PR=5,5). Ibu berkadar HSP70 yang tinggi berisiko mengalami persalinan preterm sebanyak 5,2 kali lebih besar dibanding kehamilan normal (PR=5,26 dan p=0,122). Ada perbedaan dan hubungan  antara kadar Heat Shock Protein 70 persalinan preterm dibandingkan kehamilan normal, namun didapatkan kesimpulan statistik yang tidak bermakna. LILA dan pendidikan berpengaruh bermakna terhadap kejadian persalinan preterm.Kata Kunci: Distres maternal, heat shock protein 70, persalinan preterm, lingkar lengan atas, pendidikanABSTRACT
Downloads
References
Krisnadi SR, Pramatirta AY, Siddiq A, dan Sitanggang E. Panduan Pengelolaan Persalinan Preterm Nasional. Bandung: Himpunan Kedokteran Fetomaternal; 2011.
George K, Prasad J, Singh D, et al. Perinatal Outcomes in a South Asian Setting with High Rates of Low Birth Weight. BioMed Central Pregnancy and Childbirth. 2009; 9(5): 1471-2393.
Latendresse G. The Interaction between Chronic Stress and Pregnancy: Preterm Birth from a Biobehavioral Perspective. Journal of Midwifery & Womens Health. 2009; 54(1): 8–17.
Mendelson CR. Minireview: Fetal-Maternal Hormonal Signaling in Pregnancy and Labor. Molecular Endocrinology. 2009; 23(7): 947–954.
Molvarec A, Tamasi L, Losonczy G, Madach K, Prohaszka Z, and Rigo J Jr. Circulating Heat Shock Protein 70 (HSPA1A) In Normal And Pathological Pregnancies. Cell Stress and Chaperones. 2010;15:237-247
Kramer MS, Goulet L, Lydon J, et al. Sosio-Economic Disparities in Preterm Birth: Causal Pathways and Mechanisms. Paediatrics and Perinatology Epidemiology. 2001; 15(2): 104 – 123
Soetrisno. Ekspresi Heat Shock Protein 60, 70, 90 dan Kortisol pada Persalinan Ibu Primigravida yang Mendapat Psikokuratif. [Disertasi]. Universitas Airlangga, Surabaya. 2009.
Gravett MG, Rubens CE, Nunes TM, and the GAPPS Review Group. Global Report on Preterm Birth and Stillbirth (2 of 7): Discovery Science. BioMed Central Pregnancy and Childbirth. 2010; 10(1): S2.
Koga K and Mor G. Toll-Like Receptors at the Maternal-Fetal Interface in Normal Pregnancy and Pregnancy Disorders. American Journal of Reproductive Immunology. 2010; 63(6): 587–600.
Noguchi T, Sado T, Naruse K, et al. Evidence For Activation Of Toll-Like Receptor And Receptor For Advanced Glycation End Products In Preterm Birth. Mediators of Inflammation. 2010; 2010: 1 – 10
Murti B. Desain dan Ukuran Sampel untuk Penelitian Kuantitatif dan Kualitatif di Bidang Kesehatan. Yogyakarta: Gadjah Mada University Press; 2010: hal. 108-109.
Silitonga HN. Hubungan Antara Lingkar Lengan Atas Ibu Hamil dengan Berat Badan Bayi Lahir di Medan. [Tesis]. Universitas Sumatera Utara, Medan. 2011.
Wadhwa PD, Entringer S, Buss C, and Lu MC. The Contribution of Maternal Stress to Preterm Birth: Issues and Considerations. Clinics in Perinatology. 2011; 38(3): 351–384.
Chaiworapongsa T, Erez O, Kusanovic JP, et al. Amniotic Fluid Heat Shock Protein 70 Concentration in Histologic Chorioamnionitis, Term and Preterm Parturition. Journal Maternal Fetal Neonatal Medicine. 2008; 21(7): 449-461.
Downloads
Published
Issue
Section
License
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
