Information for Reviewer

JKB telah terindex di Crossref JKB telah terindex di Google Scholar JKB telah terindex di SINTA Ristekdikti JKB telah terindex di Portal Garuda

Journal Content



Yuyun Yueniwati, N. Diana Yulisa, Arief Iskandar
  Jurnal Kedokteran Brawijaya, Vol 23, No 1 (2007),  pp.28-34  


reast cancer incidence varies in many countries but in general increases. This research aimed to find  out the accuracy of radiocolloid (lymphoscintigraphy and gamma probe) as well as blue dye method in detecting sentinel node in the early stage breast cancer. Diagnostic examination was conducted on 163 nodes of 14 patients cross sectionally, comparing the accuracy of radiocolloid and blue dye methods with  histopathologic method as the gold standard. Subject characteristics were female, aged 39-53, mostly menopause, multipara and breast-feeding. Primary tumors were mostly found in the right, upper lateral quadrant, T2, histopathologic results showed that all were of invasive ductal carcinomas and 71.4% cases were lymphatic emboli. The detection of sentinel node with lymphoscintigraphy had 81.8% accuracy,sensitivity 90.4%, specificity 73.2%, NPV 98.1%, false-negative1.8% and kappa value 0.37. Detection using gamma probe resulted in 79% accuracy, sensitivity 90.4%, specificity 67.6%, NPV 97.9%, false-negative 2% and kappa value 0.31.

Full Text:



Gondhowiardjo S, Sekarutami SM, Poetiray EDC, et al. Breast Cancer Treatment: The Role of Surgery and Irradiation. In: The Multidisciplinary Cancer Management of SolidTumors. Jakarta: Faculty of Medicine University of Indonesia 2004;225–238.

Cancer Reference Information. What are the Risk Factors for Breast Cancer.Available from: Last update: July 14. 2006.

Alazraki Np. Halkur RK. Using the sentinel node concept to stage breast cancer: Breast lymphoscintigraphy and intraoperative gamma probe sentinel node localization. In: Taillefer R, Khalkhali I, Waxman AD, Biersack HJ (editors) Radionuclide Imaging of the Breast. New York: Marcel Dekker Inc 1998;397-416.

Kuehn T, Bembenek A, Decker T, et al. A Concept for the Clinical Implementation ofSentinel Lymph Node Biopsy in Patients with Breast Carcinoma with Special Regard to Quality Assurance. Cancer 2005;103:451-461.

Schwartz GF, Giuliano AE, Veronesi U, et al. Proceedings of the Consensus Conference of the Role of Sentinel Lymph Node Biopsy in Carcinoma of the Breast April 19-22,2001, USA. Philadelphia, PA, The Breast 2002;11:362-373.

Nieweg OE, Tanis PJ, Kroon BBR. The Definition of a Sentinel Node. Annals of Surgical Oncology 2001;8:518-541.

BNMS Draft Procedure Guidelines for Radionuclide Lymphoscintigraphy for Sentinel Node Localization in Breast Carcinoma. Available from: Last updated: August 16, 2005.

Dayem HA. Sentinel node lymphoscintigraphy. In: IAEA Training Course on Scintimammography, SLN Detection and Intraoperative Surgical Probe Technology in the Management of Breast Cancer. New York: St Vincent Hospital and Medical Center. 2000.

Tanis PJ, Olmos RAV, Muller SH, Nieweg OE. Lymphatic Mapping in Patients with Breast Carcinoma: Reproducibility of Lymphoscintigraphic Results.Radiology 2003;228:546-551.

Pandey M, Deo SVS, Maharajan R. Fallacies of Preoperative Lymphoscintigraphy in Detecting Sentinel Node in Breast Cancer. World Journal of Surgical Oncology 2005;3:1-4.

Namwongprom S, Boonyaprapa S, Ekmahachai M, et al. Breast Lymphoscintigraphy for Sentinel Node Identification in Breast Cancers with Clinically-Negative Axillary Nodes. Singapore Med J 2005;46:688-692.

Kraft O, Safarcik K, Stephen A. Our Experience with Sentinel Lymph Node Detection and Biopsy in Breast Cancer and Malignant Melanoma. Scripta Medica (BRNO) 2004;77:75–84.

Dunnwald LK, Mankoff DA, Byrd DR, et al. Technical Aspects of Sentinel Node Lymphoscintigraphy for Breast Cancer. Journal of Nuclear Medicine Technology 1999;27:106-111.

Sato K, Tamaki K, Shigekawa T, et al. Clinically Useful Detection Criteria for Sentinel Nodes in Patients with Breast Cancer Using A Radioisotope Technique.Jpn J Clin Oncol 2002;32:403-406.

Schirrmeister H, Kotzerke J, Buck AK, et al. Sentinel Biopsy in Breast Cancer: Result of a German Multicenter Study. Available from : Last update: September 18, 2006.

Haigh PI, Hansen NM, Giuliano AE. Factors Affecting Sentinel Node Localization during Preoperative Breast Lymphoscintigraphy.Journal of Nuclear Medicine 2000;41:1682-1688.

Lamichhane N, Shen KW, Li Cl, et al. Sentinel Lymph Node Biopsy in Breast Cancer Patient after Overnight Migration of Radiolabelled Sulphur Colloid. Postgrad Med J 2004;80:546-550.

Chan VCY, Donohoe KJ. Association between Visualization of Internal Mammary Nodes on Breast Sentinel Node Scintigraphy and Diseased Axillary Nodes. Available from: Last updated: September 26, 2006.



  • There are currently no refbacks.