PENGEMBANGAN DIAGNOSIS TUBERKULOSIS PADA HEWAN KESAYANGAN ANJING MENGGUNAKAN ANTIGEN SPESIFIK Mycobacterium tuberculosisESAT-6 DAN CFP-10

Authors

  • Ida Tjahajati Bagian Ilmu Penyakit Dalam, Rumah Sakit Hewan Prof. Soeparwi,Fakultas Kedokteran Hewan UGM, Yogyakarta
  • Widya Asmara Bagian Mikrobiologi, Fakultas Kedokteran Hewan UGM, Yogyakarta
  • Hardyanto Soebono Bagian Kulit dan Kelamin, Fakultas Kedokteran UGM, Yogyakarta

DOI:

https://doi.org/10.21776/ub.jkb.2007.023.02.1

Abstract

Early diagnosis is one of the important methods to  control tuberculosis because this disease is zoonotic which easily spread through the air. Early detection of tuberculosis in dog is also very important since dog as petanimal have a potency to transfer the disease to human or other animals. The discovery of two specific M.tuberculosisantigens, ESAT06 and CFP-10, provide the opportunity to developa specific diagnostic kit for tuberculosis by using ELISA based on the secretion of IFN-γ. The development of a tuberculosis diagnostic kit based on this molecular biology and immunological method would provide a good alternative method to detect tuberculosis specially, accurately as early as possible. The result of this experiment would provide contribution for the development of health science and technology, especially in the eradication of tuberculosis. Keywords: diagnosis, tuberculosis, ESAT-6, CFP-10, interferon-gamma.

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References

DAFTAR KEPUSTAKAAN

Acha PN dan Szyfres B. Zoonoses and Cummunicable Diseases Common to Man andAnimal. USA, Wasington DC: Pan American Health Organization, l989; 7-19.

Thoen CO. Tuberculosis in Wild and Domestic Mammals. In Tuberculosis Pathogenesis and Control. Bloom, B.R. Editor. American Society for Microbiology, Washington,DC.1994;157-162.

Manaf A. Permasalahan Pemberantasan Tuberkulosisdi Indonesia. Seminar NasionalTuberkulosisdan Lepra.Yogyakarta:Pusat Kedokteran Tropis UGM. 1997.

Andersen P, Munk ME, Pollock JM and Doherty TM. Spesific immune-based diagnosis of tuberculosis.The Lancet; 2000;9235(356):1099-1104.

Andersen P. Replacing the tuberculin skin test with a TB specific test - a modern attempt to solve an old problem. One day seminar, Japanese Tuberculosis Meeting, 6 Mei 2004, Tokyo, Japan. 2004.

Howard AD, and Zwilling BS. Reactivation of tuberculosis is associated with a shift from type 1 to type 2 cytokines.Clin. Exp. Immunol. 1999; 115: 428-434.

Baratawidjaja KG. Imunologi Dasar. 6 Ed. Jakarta: Balai Penerbit Fakultas Kedokteran Universitas Indonesia,. 2004.

Hawthorne VM and Lauder IM. Am. Rev. Resp. Dis., 1962;85:858.

Snider WR. Tuberculosis in canine and feline populations: Review of the literature. Am. Rev. Resp. Dis., 1971;104:.877-887.

Greene CE. Mycobacterial infections. Dalam: Infectious diseases of the dog and cat. Greene CE, Ed. Philadelphia: WB Saunders Co. 1990; 558-572.

Gunn-Moore DA, Jenkins PA dan Lucke. Feline tuberculosis: a literature review and discussion of 18 cases caused an unusual mycobacterial variant. Vet. Rec. 1996;138,53-58.

Coligan JE, Kruisbeek AM, Margulies DH, Shevach EM,and Strober W. Current Protocols in Immunology, Volume III, John Wiley and Sons, Inc, United Stated of America.1997.

Tjahajati I, Projoharjono S, Soebono H, Asmara W, dan Harada N. Aktivitas sekresi reactive oxygen intermediate (ROI) pada makrofag peritoneum kucing yang diinfeksi dengan Mycobacterium tuberculosis. JSV, 2004; XXII (1):46-53.

Tjahajati I, Projoharjono S, Soebono H, Asmara W, dan Harada N. Peningkatan aktivitas fagositosis pada makrofag peritoneum kucing yang diinfeksi dengan M.tuberculosis. JSV, 2004; XXII (2):61-65.

Tjahajati I, Prodjoharjono S, Soebono H, Asmara W, dan Harada N. The profil of IFN-γ and IL-4 production by peripheral blood mononuclear cell from cats infected with M. tuberculosis. I.J. Biotech. 2003; 31-38.

Tjahajati I, Projoharjono S, Soebono H, Asmara W, Subronto YW, dan Harada N. Profil sitokin Th1-Th2 terhadap infeksi M.tuberculosis pada kucing.Media Medika Indonesiana. 2004; 39(3):137-145.

Tjahajati I, Prodjoharjono S, Soebono H, Asmara W, Subronto YW, dan Harada N. The profile of IFN-gamma and IL-4 cytokine in cat infected with Mycobacterium tuberculosis.Presentation in “Seminar of Japanese Society Veterinary Scienceâ€, Japan: Nippon University. April 4,2004.

Tjahajati I, dan Hariono B. Gambaran Darah Kucing yang Terinfeksi dengan M. tuberculosis. Jurnal SainVeteriner, 2005; 23(1): 23-24.

Tjahajati I, Projoharjono S, Soebono H, Asmara W, Subronto YW dan Harada N. Gambaran klinis dan histopatologis kucing yang terinfeksi M.tuberculosis. Jurnal Kedokteran Brawijaya, 2004;XX(2):82-91.

Tjahajati I. Tuberculosis pada kucing: Potensi pengembangan diagnosis tuberkulosis secara in vitro. Seminar Nasional Veteriner dalam rangka Lustrum Fakultas Kedokteran Hewan Universitas Gadjah Maga, 19 September 2006, di Yogyakarta. 2006.

Tjahajati I, Asmara W, dan Soebono H. Pengembangan diagnosis tuberkulosis pada hewan kesayangan anjing menggunakan antigen spesifik M.tuberculosis ESAT-6 DAN CFP-10. Seminar Klaster Kesehatan dalam rangka Dies Natalis Universitas Gadjah Mada, Desember 2006, di Yogyakarta. 2006.

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Published

2013-04-17

Issue

Vol. 23 No. 2 (2007)

Section

Research Article

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