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Hubungan antara Status Kontrol Glikemik, Vitamin D dan Gizi pada Anak Diabetes Melitus Tipe 1

Ratna Indriyani, Harjoedi Adji Tjahjono
  Jurnal Kedokteran Brawijaya, Vol 30, No 2 (2018),  pp.114-120  

Abstract


Di beberapa negara barat kasus DM tipe-1 adalah 5-10% dari kasus  diabetes, dan lebih dari 90% penderita diabetes pada anak dan remaja adalah DM tipe-1. Vitamin D berperan penting dalam membangun dan memelihara mineralisasi tulang. Defisiensi vitamin D dapat menyebabkan penekanan bone turnover sehingga menyebabkan gangguan kecepatan tinggi badan. Kontrol glikemik yang buruk berupa HbA1c yang tinggi dapat menyebabkan berat dan tinggi badan tidak naik secara adekuat. Penelitian ini bertujuan untuk membuktikan hubungan antara status kontrol glikemik(HbA1c), status vitamin D (25(OH)D), dan status gizi pada anak DM tipe-1. Desain penelitian berupa studi cross-sectional dilakukan pada 28 subjek penelitian yaitu anak DM tipe 1 usia 1-18 tahun yang menjalani rawat jalan di Poli Endokrinologi Rumah Sakit Umum dr. Saiful Anwar Malang. Kriteria eksklusi yaitu menderita penyakit autoimun lain, infeksi berat, gangguan hati, gangguan fungsi ginjal dan  anemia. Variabel yang diukur status gizi, kadar HbA1c dan 25(OH)D. Untuk mengetahui perbedaan rerata kadar 25(OH)D dan HbA1c berdasarkan status gizi digunakan uji beda Kruskal wallis, dan uji korelasi Spearman. Dari 28 subjek didapatkan 68% anak dengan status gizi baik, 64% anak dengan kontrol metabolik buruk dan 61% anak dengan defisiensi/insufisensi 25(OH)D. Tidak terdapat hubungan yang bermakna antara status gizi, kontrol glikemik,  dan vitamin D. 


Keywords


Diabetes melitus tipe 1; HbA1c; status gizi; status kontrol glikemik; status vitamin D

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References


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DOI: http://dx.doi.org/10.21776/ub.jkb.2018.030.02.7

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