Information for Reviewer
User
Index

JKB telah terindex di Crossref JKB telah terindex di Google Scholar JKB telah terindex di SINTA Ristekdikti JKB telah terindex di Portal Garuda

Notifications
Journal Content

Browse

Efek Seduhan Kopi Robusta terhadap Profil Lipid Darah dan Berat Badan Tikus yang Diinduksi Diet Tinggi Lemak

Nadie Fatimatuzzahro, Rendra Chriestedy Prasetya
  Jurnal Kedokteran Brawijaya, Vol 30, No. 1 (2018),  pp.7-11  

Abstract


Dislipidemia yang ditandai dengan meningkatnya kadar kolesterol total, trigliserida, dan Low Density Lipoproteinemia (Hyper-LDL) serta rendahnya kadar High Density Lipoprotein (HDL) termasuk salah satu faktor risiko terjadinya aterosklerosis. Asam klorogenat yang terkandung dalam kopi dapat mencegah penyerapan kolesterol di usus. Penelitian ini bertujuan untuk membuktikan efek kopi robusta (Coffea canephora) terhadap profil lipid darah dan berat badan tikus yang diberi diet tinggi lemak. Lima belas ekor tikus wistar jantan digunakan pada penelitian ini yang dibagi menjadi 3, yaitu kelompok kontrol (diet standar), hiperlipid (diet tinggi lemak) dan kopi (diet tinggi lemak dan seduhan kopi 3,6ml/hari). Diet tinggi lemak yang diberikan terdiri dari minyak babi dan kuning telur bebek. Pengukuran kadar kolesterol total, trigliserida, berat badan, LDL dan HDL dilakukan setelah 4 minggu perlakuan. Hasil uji ANOVA dan LSD menunjukkan kadar kolesterol total, trigliserida, LDL dan HDL pada kelompok kopi berbeda signifikan  dengan kelompok hiperlipid hingga sama dengan kondisi normal (kelompok kontrol). Uji ANOVA dan LSD juga membuktikan bahwa berat badan tikus yang diinduksi diet tinggi lemak juga menurun hingga sama dengan kondisi normal pada pemberian seduhan kopi. Penelitian ini membuktikan bahwa pemberian seduhan kopi dapat menurunkan kadar kolesterol total, trigliserida, dan LDL, meningkatkan kadar HDL dan menurunkan berat badan.


Keywords


Aterosklerosis; HDL; LDL; kolesterol; kopi; trigliserida

Full Text:

PDF

References


World Health Organization (WHO). Cardiovascular Diseases (CVDs). (Online) 2013. http://www.who.int/mediacentre/factsheets/fs317/en/ [diakses tanggal 9 Maret 2017].

Hamoud MK. Coronary Artery Disease. Spring: Tufts-New England Medical Center; 2008; pp. 1-13.

Tomkin GH and Daphne O. LDL as a Cause of Atherosclerosis. The Open Atherosclerosis and Thrombosis Journal. 2012; 5: 13-21.

Ismawati, Oenzil F, Yanwirasti, dan Yerizel E. Analisis Konsentrasi Low Density Lipoprotein Teroksidasi Serum pada Tahap Aterosklerosis. Jurnal Kedokteran Brawijaya. 2017; 29(4): 348-352.

Vogiatzi G, Tousoulis D, and Stefanadis C. The Role of Oxidative Stress in Atherosclerosis. Hellenic Journal of Cardiology. 2009; 50(5): 402-409.

Ding M, Bhupathiraju SN, Satija A, van Dam RM, and Hu FB. Long-Term Coffee Consumption and Risk of Cardiovascular Disease: A Systematic Review and a Dose-Response Meta-Analysis of Prospective Cohort Studies. Circulation. 2014; 129(6): 643-659.

Yashin YI, Cheurnousova NI, Fedina PA, Levin DA, and Mironov SA. Determination of Antioxidants in Coffee by an Amperometric Method. Beer Beverages. 2009; 2: 45-47.

Hall S, Desbrow B, Dukie SA, et al. A Review of the Bioactivity of Coffee, Caffeine and Key Coffee Constituents on Inflammatory Responses Linked to Depression. Food Research International. 2015; 76(3): 626–636.

Bonita JS, Mandarano M, Shuta D, and Vinson J. Coffee and Cardiovascular Disease: In Vitro, Cellular, Animal, and Human Studies. Pharmacological Research. 2007; 55(3): 187–198.

Yashin A, Yashin Y, Wang JY, and Nemzer B. Antioxidant and Antiradical Activity of Coffee. Antioxidants. 2013; 2: 230-245.

Daly JW. Caffeine Analogs: Biomedical Impact. Cellular Molecular Life Science. 2007; 64(16): 2153-2169.

Zhang WL, Garcia EL, Li TY, Hu FB, and van Dam RM. Coffee Consumption and Risk of Cardiovascular Events and All-Cause Mortality among Women with Type 2 Diabetes. Diabetologia. 2009; 52(5): 810–817.

Ong KW, Hsu A, and Tan BK. Anti-Diabetic and Anti-Lipidemic Effects of Chlorogenic Acid are Mediated by Ampk Activation. Biochemical Pharmacology. 2013; 85(9): 1341-1351.

Harsa IMS. Efek Pemberian Diet Tinggi Lemak terhadap Profil Lemak Darah Tikus Putih (Rattus Norvegicus). Jurnal Ilmiah Kedokteran. 2014; 3(1): 21-28.

Susilawati IA, Suryono, and Tantin E. Protective Effect of Coffee Against Coronary Atherosclerosis in Periodontitis Rat Model (Online). 2014. http://repository.unej.ac.id/bitstream/handle/123456789/63466/1%20Dewa%20Ayu%Susilawati upt 26.pdf?sequence=1 [diakses pada 15 Mei 2017].

Nagao T, Ochiai R, Watanabe T, et al. Visceral Fat-Reducing Effect of Continuous Coffee Beverage Consumption in Obese Subjects. Japan Pharmacological Therapy. 2009; 37: 333-344.

Choi BK, Park SB, Lee DR, et al. Green Coffee Bean Extract Improves Obesity by Decreasing Body Fat in High-Fat Diet-Induced Obese Mice. Asian Pacific Journal of Tropical Medicine. 2016;9(7):635–643.

Li SY, Chang CQ, Ma FY, and Yu CL. Modulating Effects of Chlorogenic Acid on Lipids and Glucose Metabolism and Expression of Hepatic Peroxisome Proliferator-Activated Receptor-Alpha in Golden Hamsters Fed on High Fat Diet. Biomedical and Environmenal Sciences. 2009; 22(2): 122-129.

Khan FA, Maalik A, and Murtaza G. Inhibitory Mechanism Against Oxidative Stress of Caffein Acid. Journal of Food and Drug Analysis. 2016; 24(4): 695-702.

Cho AS, Jeon SM, Kim MJ, et al. Chlorogenic Acid Exhibits Anti-Obesity Property and Improves Lipid Metabolism in High-Fat Diet-Induced-Obese Mice. Food and Chemical Toxicology. 2010; 48 (3): 937-943.

Ota N, Soga S, Murase T, Shimotoyodome A, and Hase T. Consumption of Coffee Polyphenols Increase Fat Utilization in Human. Journal of Health Science. 2010; 56(6): 745-751.

Narita Y and Inouye KJ. Kinetic Analysis and Mechanism on the Inhibition of Chlorogenic Acid and Its Components Against Porcine Pancreas Alpha-Amylase Isozymes I and II. Journal of Agricultural and Food Chemistry. 2009; 57(19): 9218-9225.

Ong KW, Hsu A, and Tan BKH. Chlorogenic Acid Stimulates Glucose Transport in Skeletal Muscle Via APMK Activation: A Contributor to the Beneficial Effects of Coffee on Diabetes. PLoS One. 2012; 7(3): e32718.

Tomkin GH and Owens D. The Chylomicron: Relationship to Atherosclerosis. International Journal of Vascular Medicine. 2012; 2012: 1-13.

Craeyveld EV, Lievens J, Jacobs F, Feng Y, Snoeys J, and Geest BD. Apolipoprotein A-I and Lecithin: Cholesterol Acyltransferasetransfer Induce Cholesterol Unloading Incomplex Atherosclerotic Lesions. Gene Therapy. 2009; 16(6): 757–765.

Khera AV, Cuchel M, Moya ML, et al. Cholesterol Efflux Capacity, High-Density Lipoprotein Function, and Atherosclerosis. The New England Journal of Medicine. 2011; 364: 127-135.

Murase T, Misawa K, Minegishi Y, et al. Coffee Polyphenols Suppress Diet-Induced Body Fat Accumulation by Downregulating SREBP-1C and Related Molecules in C57BL/6J Mice. American Journal of Physiology. Endocrinology and Metabolism. 2011; 300(1): E122-E133.




DOI: http://dx.doi.org/10.21776/ub.jkb.2018.030.01.2

Refbacks

  • There are currently no refbacks.