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Gambaran Pola Pengobatan dan Fungsi Kognitif Pasien Epilepsi di RSJ Mutiara Sukma

herpan syafii harahap, Yanna - Indrayana, Emmy - Amalia
  Jurnal Kedokteran Brawijaya, Vol 29, No. 4 (2017),    

Abstract


Epilepsi merupakan suatu gangguan pada sistem saraf pusat yang memiliki dampak neurobiologik, kognitif, psikologik, dan sosial. Penggunaan obat antiepilepsi diperlukan untuk mencegah komplikasi yang ditimbulkan oleh epilepsi. Salah satu komplikasi penting dari epilepsi adalah terjadinya gangguan fungsi kognitif. Penelitian ini bertujuan untuk mengetahui gambaran pola pengobatan dan fungsi kognitif pasien epilepsi di RSJ Mutiara Sukma Provinsi NTB. Sebanyak 97 subyek dilibatkan dalam penelitian potong lintang yang dilakukan pengambilan data meliputi usia, jenis kelamin, usia awitan bangkitan, tipe bangkitan, etiologi bangkitan, dan obat antiepilepsi yang digunakan. Fungsi kognitif dari 45 subyek penelitian diperiksa menggunakan instrumen MoCA-INA dan TMT-B. Hasil penelitian menunjukkan 80,4% subyek mendapatkan monoterapi OAE. Monoterapi yang digunakan antara lain fenitoin (30,9%), karbamazepin (27,8%), dan asam valproat (21,7%). Pada pemeriksaan MoCA-INA, 100% subyek memiliki skor < 26. Pada pemeriksaan TMT-B, 91,11% subyek memiliki hasil pemeriksaan tidak normal. Sebagian besar pasien epilepsi di RSJ Mutiara Sukma mendapatkan monoterapi. Obat antiepilepsi yang paling banyak digunakan sebagai monoterapi adalah fenitoin. Sebagian besar subyek penelitian mengalami gangguan fungsi kognitif, terutama pada domain atensi dan fungsi eksekutif.


Keywords


epilepsi, obat antiepilepsi, gangguan fungsi kognitif

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