IDENTIFIKASI MUTASI GEN CYSTATIONINE-β SYNTHASE (CBS) DAN GEN METHYLENETETRAHYDROFOLATE REDUCTASE (MTHFR) PADA PENDERITA PREMATUR INFARK MIOKARD AKUT DENGAN HIPERHOMOSISTEINEMI
DOI:
https://doi.org/10.21776/ub.jkb.2008.024.03.3Abstract
ABSTRACT
Hyperhomocysteinemia appears to be an independent risk factor for coronary heart disease. Elevated levels
of plasma total homocysteine (tHcy) was caused by genetic or nutrient-related disturbances in the
transsulfuration or remethylation pathways for homocysteine metabolism. This study observed premature
myocard infarct acute patients with hyperhomocysteinemia.The aim of the research was to determine
Cystarhionine-β Synthase and Methylenetetrahydrofolate Reductase genes mutations in premature acute
myocard infarct patients with hyperhomocysteinemia.This study was a cross sectional study in premature
acute myocard infarct patients. Twenty three patients were examined for plasma total homocysteine, vitamin
B6, vitamin B12 folic acid and lipid profile. Total DNA isolated from patients with hyperhomocystememia and
normal folic acid, vitamin B6, vitamin B12 levels and lipid profile. Five patients were assayed for
Cystathionine-β Synthase and gen Methylenetetrahydrofolate Reductase genese mutations by Polymerase
Chain Reactions (PCR). Five from 23 patients ( 21,7% ) plasma total
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