Hubungan Pola Penggunaan OAINS dengan Gejala Klinis Gastropati pada Pasien Reumatik
DOI:
https://doi.org/10.21776/ub.jkb.2010.026.02.8Abstract
ABSTRAKKata Kunci :
Obat Anti Inflamasi Non Steroid (OAINS) merupakan obat pilihan utama untuk osteoartritis. Penggunaan OAINS yang
kurang tepat dapat menyebabkan gastropati. Penelitian ini bertujuan untuk mengetahui hubungan pola penggunaan
OAINS dengan gejala klinis gastropati pada pasien reumatik Penelitian dilakukan dengan desain cross sectional pada 40
orang pasien dipilih dengan metode consecutive sampling. Penelitian ini menilai pola pengguaan OAINS (jenis, lama
penggunaan, cara penggunaan,   pemakaian obat sitoproteksi ) dan gejala klinis gastropati yang timbul. 55% pasien
mengalami gejala klinis gastropati berupa sindrom dispepsia. Uji Kruskal Wallis gejala klinis gastropati antara penggunaan
Na diclofenac, meloxicam, dengan ibuprofen menunjukkan p = 0,732. Uji regresi logistik lama penggunaan dengan gejala
klinis gastropati menunjukkan p = 0,047. Uji Mann Whitney gejala klinis gastropati pada penggunaan OAINS secara
periodik dengan berkelanjutan menunjukkan p > 0,05. Uji Mann Whitney gejala klinis gastropati pada penggunaan OAINS
bersama obat sitoproteksi dengan penggunaan OAINS tanpa obat sitoproteksi menunjukkan p = 0,000. Penelitian ini
membuktikan bahwa jenis OAINS tidak memberikan perbedaan gejala klinis gastropati, demikian juga penggunaan
periodik dan berkelanjutan. Dibuktikan juga bahwa lama penggunaan OAINS berhubungan dengan gejala klinis gastropati
dan penggunaan obat sitoproteksi bersama dengan OAINS mengurangi gejala klinis gastropati.
Gastropati, OAINS, reumatik
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