Efek Quercetin terhadap Kadar Adipocyte-Fatty Acid Binding Protein

Authors

  • Sudiarto Sudiarto 1 Laboratorium Ilmu Faal Fakultas Kedokteran Universitas Brawijaya Malang
  • Setyawati Soeharto K Laboratorium Farmakologi Fakultas Kedokteran Universitas Brawijaya Malang 3
  • Shinta Febrina Pendidikan Dokter Fakultas Kedokteran Universitas Brawijaya Malang

DOI:

https://doi.org/10.21776/ub.jkb.2010.026.01.2

Abstract

ABSTRAKDiet tinggi lemak, meningkatkan resiko aterosklerosis akibat stress oksidatif LDL yang di tunjukkan dengan peningkatan petanda  inflamasi Adipocyte Fatty Acid Binding Protein  ( A-FABP  ). Quercetin, senyawa  flavonoid mempunyai potensi antioksidan. Penelitian dilakukan untuk membuktikan efek pemberian quercetin  terhadap penurunan serum A-FABP. Desain post test only control group dilakukan dengan hewan coba tikus wistar  jantan yang di bagi dalam 2 kelompok control  dengan  diet  normal  dan  1% methylcellulose  group,  diet  tinggi  lemak  dengan  1% methylcellulose,  dan  tiga kelompok  perlakuan  dengan  diet  tinggi  lemak  dan  pemberian  quercetin  dosis  2mg/kgBB,  10mg/kgBB,  quercetin 50mg/kgBB. Berbeda dengan hipotesis uji pearson menunjukkan hubungan korelasi positif peningkatan dosis quercetin   dengan AFBP serum concentrations  ( p<0.05,  r=0,97).Kata Kunci  : Adipocyte –Fatty Acid Binding Protein, diet  tinggi  lemak, quercetin

Downloads

Download data is not yet available.

References

DAFTAR PUSTAKA

Ross R. The Pathogenesis of Atherosclerosis: A Perspective for the 1990s. Nature. 1993; 362: 801.

Faxon DP, Fuster V, Libby P, et al. therosclerotic Vascular Disease Conference: Writing Group III: Pathophysiology. Circulation. 2004; 109(21): 2617.

Tsimikas S, Bergmark C, Beyer RW, et al. Temporal

ncreases in Plasma Markers of Oxidized Low-density Lipoprotein Strongly Reflect the Presence of Acute Coronary Syndromes. Journal of the American College Cardiology. 2003; 41: 360.

Inoue T, Uchida T, Kamishirado H, Takayangi K, Hayashi T, and Morooka S. Clinical Significance of Antibody Against Oxidized Low Density Lipoprotein in Patients with Atherosclerotic Coronary Artery Disease. Journal of American College Cardiology. 2001; 37: 775.

Bui MN, Sack MN, Moutsatsos G, et al. Auto-antibody Titers to Oxidized LDL in Patients with Coronary Atherosclerosis. American Heart Journal. 1996; 131: 663.

Indriyanti RS. Peran Asam Lemak Bebas, Stres Oksidatif & Keadaan Inflamasi Terhadap Kejadian Resistensi Insulin. Forum Diagnosticum. 2006: 6: 34-39.

Mulyohadi A, Djanggan S, Ketut M, et al. Effect of Seaweeds Caulerpa Racemosa in Atherogenic Diets of Rats (Rattus norvegicus Strain Wistar). Proyek Penelitian Grup Atherosklerosis Biomedik Universitas Brawi jaya. Fakultas Kedokteran Universitas Brawijaya, Malang. 2002.

Peeters W, Kleijn DP, Vink A, et al. Adipocyte Fatty Acid Binding Protein in Atherosclerotic Plaques is Associated with Local Vulnerability and is Predictive for the Occurence of Adverse Cardiovascular Events. European Heart Journal. 2011; 32(4): 1758-1768.

Layne MD, Patel A, Chen YH, et al. Role of Macrophage-expressed Adipocyte Fatty Acid Binding Protein in the Development of Accelerated Atherosclerosis in Hypercholesterolemic Mice. The Journal of the Federation of American Societies for Experimental Biology. 2001; 15(14): 2733-2735.

Makowski L and Hotamisligil GS. The Role of Fatty Acid Binding Proteins in Metabolic Syndrome and Atherosclerosis. Current Opinion Lipidology. 2005; 16(5): 543-548

Perrella MA, Pellacani A, Layne MD, et al. Absence of Adipocyte Fatty Acid Binding Protein Prevents the Development of Accelerated Atherosclerosis in Hypercholesterolemic Mice. The Journal of the Federation of American Societies for Experimental Biology. 2001; 15(10): 1774-1776.

Furuhashi M, Tuncman G, Gorgun CZ, et al. Treatment of Diabetes and Atherosclerosis by Inhibiting Fatty-Acid Binding Protein aP2. Nature Review Drugs Recovery. 2007; 447: 959-965.

Furuhashi M and Hotamisligil GS. Fatty Acid Binding Proteins: Role in Metabolic Diseases and Potential as Drug Targets. Nature Review Drugs Recovery. 2008; 7: 489-503.

Xu A, Wang Y , Xu J, et al. Adipocyte Fatty Acid Binding

rotein is a Plasma Biomarker Closely Associated with the Obesity and Metabolic Syndrome. Clinical Chemistry. 2006; 52(3): 405-413.

Kawai Y, Nishikawa T, Shiba Y, Saito S, et al. Macrophage as a Target of Quercetin Glucuronides in Human Atherosclerotic Arteries. The Journal of Biological Chemistry. 2008; 283(14): 9424-9434.

Enkhmaa B, Shiwaku K, Katsube T, et al. Mulberry Leaves and Their Major Flavonol Quercetin Attenuate Atherosclerotic Lesion Development in LDL Receptor-Defficient Mice. Journal of Nutrition. 2005; 135(4): 729-734.

Reiterer G, Toborek M, and Hennig B. Quercetin Protects Against Linoleic Acid-induced Porcine Endothelial Cell Dysfunction. The Journal of Nutrition. 2004; 1(34): 771-775

Hayek T, Fuhrman B, Vaya J, et al. Reduced Progession of Atherosclerosis in Apoliporotein E-defficient Mice Following Consumption of Red Wine, or its Plyphenol Quercetin or Catechin, is Associated with the Reduced Susceptibility of LDL to Oxydation and Aggregation. Ateriosclerosis, Thrombosis and Vascular Biology Journal. 1997; 17(11): 2744-2752.

Afanas’ev IB, Dorozhko AJ, Brodski AV, Kostyuk AV, and Potapovitch AI. Chelating and Free Radical Scavenging Mechanisms of Inhibitory Action of Rutin and Quercetin in Lipid Peroxidation. Biochemical Pharmacology. 1989; 38(11): 1763-1769.

Clark LJ. Interstitial Cystitis Quercetin. National enter for Biotechnology Information. 2010; 32: 155.

Downloads

Published

2013-03-11

Issue

Vol. 26 No. 1 (2010)

Section

Research Article

License

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).